Amalia Peterson1, Sarah E Tom2. 1. Department of Neurology, College of Physicians and Surgeons, Columbia University, 622 W. 168th Street, New York, NY, 10032, USA. ajp2260@cumc.columbia.edu. 2. Department of Neurology, College of Physicians and Surgeons, Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, USA.
Abstract
PURPOSE OF REVIEW: The prevalence of Alzheimer's disease and related dementias is greater in women compared to men. We provide a review of female sex-specific risk factors across the lifecourse for cognition in older adulthood, highlighting areas that need further study. RECENT FINDINGS: Pregnancy may affect late-life cognition, with adverse pregnancy outcomes associated with an increased risk of cognitive decline but parity providing a protective effect. Cumulative estrogen exposure, influenced by age of menarche, menopause, and exogenous estrogen use, may modify a woman's risk for dementia. Menopause transition-associated symptoms may impact cognitive health at the time of the symptoms, but long-term effects remain unknown. As compared to natural menopause, surgical menopause seems to increase the risk for cognitive impairment. Studies that have assessed the association between women's reproductive health and cognition have produced conflicting results. Future studies that address these inconsistencies among diverse populations are needed to better care for women throughout their lives.
PURPOSE OF REVIEW: The prevalence of Alzheimer's disease and related dementias is greater in women compared to men. We provide a review of female sex-specific risk factors across the lifecourse for cognition in older adulthood, highlighting areas that need further study. RECENT FINDINGS: Pregnancy may affect late-life cognition, with adverse pregnancy outcomes associated with an increased risk of cognitive decline but parity providing a protective effect. Cumulative estrogen exposure, influenced by age of menarche, menopause, and exogenous estrogen use, may modify a woman's risk for dementia. Menopause transition-associated symptoms may impact cognitive health at the time of the symptoms, but long-term effects remain unknown. As compared to natural menopause, surgical menopause seems to increase the risk for cognitive impairment. Studies that have assessed the association between women's reproductive health and cognition have produced conflicting results. Future studies that address these inconsistencies among diverse populations are needed to better care for women throughout their lives.
Entities:
Keywords:
Alzheimer’s disease; Dementia; Reproductive health; Risk factors; Sex; Women
Authors: Emanuel C Trabuco; Patricia G Moorman; Alicia Algeciras-Schimnich; Amy L Weaver; William A Cliby Journal: Obstet Gynecol Date: 2016-05 Impact factor: 7.661
Authors: Riley Bove; Elizabeth Secor; Lori B Chibnik; Lisa L Barnes; Julie A Schneider; David A Bennett; Philip L De Jager Journal: Neurology Date: 2013-12-11 Impact factor: 9.910
Authors: Sonia M Grandi; Kristian B Filion; Sarah Yoon; Henok T Ayele; Carla M Doyle; Jennifer A Hutcheon; Graeme N Smith; Genevieve C Gore; Joel G Ray; Kara Nerenberg; Robert W Platt Journal: Circulation Date: 2019-02-19 Impact factor: 29.690
Authors: Shahram Oveisgharan; Zoe Arvanitakis; Lei Yu; Jose Farfel; Julie A Schneider; David A Bennett Journal: Acta Neuropathol Date: 2018-10-17 Impact factor: 17.088
Authors: Joon Hyung Jung; Ga Won Lee; Jun Ho Lee; Min Soo Byun; Dahyun Yi; So Yeon Jeon; Gi Jung Jung; Haejung Joung; Seong A Shin; Yu Kyeong Kim; Koung Mi Kang; Chul-Ho Sohn; Dong Young Lee Journal: Front Aging Neurosci Date: 2020-06-03 Impact factor: 5.750
Authors: Yasmin A Harrington; Jeanine M Parisi; Daisy Duan; Darlynn M Rojo-Wissar; Calliope Holingue; Adam P Spira Journal: Front Aging Neurosci Date: 2022-07-14 Impact factor: 5.702