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Literature DB >> 34224317

Biomarkers for early detection of pancreatic cancer - miRNAs as a potential diagnostic and therapeutic tool?

Aleksandra Tarasiuk¹, Tomasz Mackiewicz¹, Ewa Małecka-Panas², Jakub Fichna¹.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies, with poor prognosis resulting mostly from late diagnosis. Surgery remains the most effective treatment and early detection significantly increases the overall survival. Biomarkers used for diagnosis and to monitor the response to treatment, such as carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA), are not adequate as early detection markers of PDAC, partly due to low sensitivity/specificity. Therefore, new biomarkers for PDAC are critically needed. This review aims at recent advancements in the identification and characterization of new biomarkers, microRNAs, which might prove useful in the early detection of PDAC.

Entities: Chemical

Keywords: Pancreatic ductal adenocarcinoma; biomarkers; early detection; miRNA

Mesh：

Substances：

Year: 2021 PMID： 34224317 PMCID： PMC8386725 DOI： 10.1080/15384047.2021.1941584

Source DB: PubMed Journal: Cancer Biol Ther ISSN： 1538-4047 Impact factor: 4.875

52 in total

1. Serum microRNA expression profile as a biomarker in the diagnosis and prognosis of pancreatic cancer.

Authors: Rui Liu; Xi Chen; Yiqi Du; Weiyan Yao; Lin Shen; Cheng Wang; Zhibin Hu; Rui Zhuang; Guang Ning; Chunni Zhang; Yaozong Yuan; Zhaoshen Li; Ke Zen; Yi Ba; Chen-Yu Zhang
Journal: Clin Chem Date: 2011-12-22 Impact factor: 8.327

2. Frequent detection of pancreatic lesions in asymptomatic high-risk individuals.

Authors: Marcia Irene Canto; Ralph H Hruban; Elliot K Fishman; Ihab R Kamel; Richard Schulick; Zhe Zhang; Mark Topazian; Naoki Takahashi; Joel Fletcher; Gloria Petersen; Alison P Klein; Jennifer Axilbund; Constance Griffin; Sapna Syngal; John R Saltzman; Koenraad J Mortele; Jeffrey Lee; Eric Tamm; Raghunandan Vikram; Priya Bhosale; Daniel Margolis; James Farrell; Michael Goggins
Journal: Gastroenterology Date: 2012-01-12 Impact factor: 22.682

Review 3. Key biological processes driving metastatic spread of pancreatic cancer as identified by multi-omics studies.

Authors: T Y S Le Large; M F Bijlsma; G Kazemier; H W M van Laarhoven; E Giovannetti; C R Jimenez
Journal: Semin Cancer Biol Date: 2017-03-30 Impact factor: 15.707

Review 4. Early Detection of Pancreatic Cancer: Opportunities and Challenges.

Authors: Aatur D Singhi; Eugene J Koay; Suresh T Chari; Anirban Maitra
Journal: Gastroenterology Date: 2019-02-02 Impact factor: 22.682

5. Exosomes derived from cancer stem cells of gemcitabine-resistant pancreatic cancer cells enhance drug resistance by delivering miR-210.

Authors: Zhiyong Yang; Ning Zhao; Jing Cui; Heshui Wu; Jiongxin Xiong; Tao Peng
Journal: Cell Oncol (Dordr) Date: 2019-11-12 Impact factor: 6.730

Review 6. New Treatment Strategies for Metastatic Pancreatic Ductal Adenocarcinoma.

Authors: Ritu Raj Singh; Eileen M O'Reilly
Journal: Drugs Date: 2020-05 Impact factor: 9.546

7. Selection of reference genes is critical for miRNA expression analysis in human cardiac tissue. A focus on atrial fibrillation.

Authors: Michela Masè; Margherita Grasso; Laura Avogaro; Elvira D'Amato; Francesco Tessarolo; Angelo Graffigna; Michela Alessandra Denti; Flavia Ravelli
Journal: Sci Rep Date: 2017-01-24 Impact factor: 4.379

8. Diagnostic and therapeutic recommendations in pancreatic ductal adenocarcinoma. Recommendations of the Working Group of the Polish Pancreatic Club.

Authors: Katarzyna Winter; Renata Talar-Wojnarowska; Andrzej Dąbrowski; Małgorzata Degowska; Marek Durlik; Anita Gąsiorowska; Stanisław Głuszek; Grażyna Jurkowska; Aleksandra Kaczka; Paweł Lampe; Tomasz Marek; Anna Nasierowska-Guttmejer; Ewa Nowakowska-Duława; Grażyna Rydzewska; Janusz Strzelczyk; Zbigniew Śledziński; Ewa Małecka-Panas
Journal: Prz Gastroenterol Date: 2019-03-12