Literature DB >> 34223938

[Need for real-world data studies on hidradenitis suppurativa/acne inversa treatment].

C C Zouboulis1,2, E von Stebut3.   

Abstract

Publication of real world data on the results of treatment with (approved) drugs is important to allow for a reasonable judgement about the efficacy of a medication, especially since due to the nature of controlled clinical studies certain patient groups, who in daily clinical routine would best benefit from such new treatments, are excluded from study inclusions. In the present review, real-world data on the treatment of hidradenitis suppurativa (HS) are summarized. It appears that adalimumab, as the only approved biological treatment so far, represents a cost-efficient and effective therapy. Patient education is important to increase treatment adherence and efficacy. The baseline IHS4 score has proven to be a meaningful predictor for recurrences during adalimumab therapy. Additional publications on real-world data including high numbers of patients with different risk factors are required to meaningly evaluate the evolving therapeutic spectrum of treatment options for HS in clinical practice.
© 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Entities:  

Keywords:  Adalimumab; Clinical studies; Drug efficacy; Patient education; Real-world data

Year:  2021        PMID: 34223938     DOI: 10.1007/s00105-021-04847-9

Source DB:  PubMed          Journal:  Hautarzt        ISSN: 0017-8470            Impact factor:   0.751


  5 in total

1.  The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa: Results of a prospective European cohort study.

Authors:  Kelsey R van Straalen; Thrasyvoulos Tzellos; Phillipe Guillem; Farida Benhadou; Carlos Cuenca-Barrales; Mathilde Daxhelet; Mathieu Daoud; Ourania Efthymiou; Evangelos J Giamarellos-Bourboulis; Gregor B E Jemec; Alexandros C Katoulis; Anke Koenig; Elizabeth Lazaridou; Angelo V Marzano; Łucas Matusiak; Alejandro Molina-Leyva; Chiara Moltrasio; Andreas Pinter; Concetta Potenza; Jorge Romaní; Ditte M Saunte; Nevena Skroza; Dimitra Stergianou; Jacek Szepietowski; Anastasia Trigoni; Eva Vilarrasa; Hessel H van der Zee
Journal:  J Am Acad Dermatol       Date:  2021-01-20       Impact factor: 11.527

2.  Adalimumab dose intensification in hidradenitis suppurativa: effectiveness and safety results of a multicenter study.

Authors:  E M Sánchez Martínez; G Murray; F Alfageme Roldán; R García Ruiz; A M Tobin; C C Zouboulis
Journal:  Br J Dermatol       Date:  2021-05-29       Impact factor: 9.302

3.  May COVID-19 infection induce a paradoxical improvement of a non-responsive case of hidradenitis suppurativa?

Authors:  Raffaele D Caposiena Caro; Chiara Pensa; Sara Lambiase; Eleonora Candi; Luca Bianchi
Journal:  Ital J Dermatol Venerol       Date:  2021-07-20

4.  Patient Support Program Increased Medication Adherence with Lower Total Health Care Costs Despite Increased Drug Spending.

Authors:  Diana Brixner; David T Rubin; Philip Mease; Manish Mittal; Harry Liu; Matthew Davis; Arijit Ganguli; A Mark Fendrick
Journal:  J Manag Care Spec Pharm       Date:  2019-05-11

5.  Prevalence of Hidradenitis Suppurativa: A Systematic Review and Meta-regression Analysis.

Authors:  Abdulhadi Jfri; David Nassim; Elizabeth O'Brien; Wayne Gulliver; Georgios Nikolakis; Christos C Zouboulis
Journal:  JAMA Dermatol       Date:  2021-08-01       Impact factor: 11.816

  5 in total

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