Lucía Iglesias-Vázquez1,2, Victoria Arija3,4,5, Núria Aranda1,2, Elom K Aglago6, Amanda J Cross7, Matthias B Schulze8,9, Daniel Quintana Pacheco10, Tilman Kühn10, Elisabete Weiderpass6, Rosario Tumino11, Daniel Redondo-Sánchez12,13,14, Maria Santucci de Magistris15, Domenico Palli16, Eva Ardanaz17,18,19, Nasser Laouali20, Emily Sonestedt21, Isabel Drake21, Lucía Rizzolo22, Carmen Santiuste19,23, Carlotta Sacerdote24, Ramón Quirós25, Pilar Amiano19,26, Antonio Agudo22, Paula Jakszyn27,28. 1. Research group of Nutrition and Mental Health (NUTRISAM), Unit of Nutrition and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV), Tarragona, Spain. 2. Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. 3. Research group of Nutrition and Mental Health (NUTRISAM), Unit of Nutrition and Public Health, Faculty of Medicine and Health Sciences, Universitat Rovira i Virgili (URV), Tarragona, Spain. victoria.arija@urv.cat. 4. Institut d'Investigació Sanitària Pere Virgili (IISPV), Reus, Spain. victoria.arija@urv.cat. 5. Institut d'investigació en Atenció Primària (IDIAP) Jordi Gol, Institut Català de la Salut (ICS), Barcelona, Spain. victoria.arija@urv.cat. 6. International Agency for Research on Cancer (IARC), Lyon, France. 7. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. 8. Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany. 9. Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. 10. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 11. Cancer Registry and Histopathology Department, Provincial Health Authority (ASP 7) Ragusa, Ragusa, Italy. 12. Escuela Andaluza de Salud Pública (EASP), Granada, Spain. 13. Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain. 14. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 15. Azienda Ospedialiera Universitaria (A.O.U.) Federico II, Naples, Italy. 16. Cancer Risk Factors and Life-Style Epidemiology Unit Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Villa delle Rose, Florence, Italy. 17. Navarra Public Health Institute, Pamplona, Spain. 18. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. 19. CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. 20. Paris-Saclay University, UVSQ, University Paris-Sud, Inserm, Gustave Roussy, "Exposome and Heredity" Team, CESP, 94805, Villejuif, France. 21. Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden. 22. Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute -(IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. 23. Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain. 24. Unit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital, Via Santena 7, 10126, Turin, Italy. 25. EPIC Asturias, Public Health Directorate, Asturias, Spain. 26. Public Health Division of Gipuzkoa, BioDonostia Research Institute, Donostia-San Sebastian, Spain. 27. Unit of Nutrition and Cancer, Catalan Institute of Oncology - ICO, Nutrition and Cancer Group, Bellvitge Biomedical Research Institute -(IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. paujak@iconcologia.net. 28. Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain. paujak@iconcologia.net.
Abstract
PURPOSE: Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. METHODS: Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. RESULTS: Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. CONCLUSION: Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
PURPOSE: Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. METHODS: Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case-control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic inflammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. RESULTS: Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was significantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex differences even after excluding participants with hsCRP > 5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. CONCLUSION: Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
Authors: Odilson M Silvestre; Alexandra Gonçalves; Wilson Nadruz; Brian Claggett; David Couper; John H Eckfeldt; James S Pankow; Stefan D Anker; Scott D Solomon Journal: Eur J Heart Fail Date: 2016-12-14 Impact factor: 15.534
Authors: Karina Meidtner; Clara Podmore; Janine Kröger; Yvonne T van der Schouw; Benedetta Bendinelli; Claudia Agnoli; Larraitz Arriola; Aurelio Barricarte; Heiner Boeing; Amanda J Cross; Courtney Dow; Kim Ekblom; Guy Fagherazzi; Paul W Franks; Marc J Gunter; José María Huerta; Paula Jakszyn; Mazda Jenab; Verena A Katzke; Timothy J Key; Kay Tee Khaw; Tilman Kühn; Cecilie Kyrø; Francesca Romana Mancini; Olle Melander; Peter M Nilsson; Kim Overvad; Domenico Palli; Salvatore Panico; J Ramón Quirós; Miguel Rodríguez-Barranco; Carlotta Sacerdote; Ivonne Sluijs; Magdalena Stepien; Anne Tjonneland; Rosario Tumino; Nita G Forouhi; Stephen J Sharp; Claudia Langenberg; Matthias B Schulze; Elio Riboli; Nicholas J Wareham Journal: Diabetes Care Date: 2017-11-22 Impact factor: 19.112
Authors: Clara Podmore; Karina Meidtner; Matthias B Schulze; Robert A Scott; Anna Ramond; Adam S Butterworth; Emanuele Di Angelantonio; John Danesh; Larraitz Arriola; Aurelio Barricarte; Heiner Boeing; Françoise Clavel-Chapelon; Amanda J Cross; Christina C Dahm; Guy Fagherazzi; Paul W Franks; Diana Gavrila; Sara Grioni; Marc J Gunter; Gaelle Gusto; Paula Jakszyn; Verena Katzke; Timothy J Key; Tilman Kühn; Amalia Mattiello; Peter M Nilsson; Anja Olsen; Kim Overvad; Domenico Palli; J Ramón Quirós; Olov Rolandsson; Carlotta Sacerdote; Emilio Sánchez-Cantalejo; Nadia Slimani; Ivonne Sluijs; Annemieke M W Spijkerman; Anne Tjonneland; Rosario Tumino; Daphne L van der A; Yvonne T van der Schouw; Edith J M Feskens; Nita G Forouhi; Stephen J Sharp; Elio Riboli; Claudia Langenberg; Nicholas J Wareham Journal: Diabetes Care Date: 2016-02-09 Impact factor: 19.112