| Literature DB >> 34210972 |
Min-Min Lou1,2, Xiao-Qiang Tang1,2, Guang-Ming Wang3,4,5, Jia He1,2, Fang Luo1, Ming-Feng Guan1,2, Fei Wang1,2, Huan Zou1,2, Jun-Ying Wang1,2, Qun Zhang6, Ming-Jian Xu1, Qi-Li Shi1, Li-Bing Shen1, Guo-Ming Ma1,2, Yi Wu6, Yao-Yang Zhang1, Ai-Bin Liang5, Ting-Hua Wang7, Liu-Lin Xiong7, Jian Wang8, Jun Xu9, Wen-Yuan Wang10,11,12.
Abstract
Long noncoding RNAs (lncRNAs) are known to regulate DNA damage response (DDR) and genome stability in proliferative cells. However, it remains unknown whether lncRNAs are involved in these vital biological processes in post-mitotic neurons. Here, we report and characterize a lncRNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system. BS-DRL1 is a brain-specific lncRNA and depletion of BS-DRL1 in neurons leads to impaired DDR upon etoposide treatment in vitro. Mechanistically, BS-DRL1 interacts with HMGB1, a chromatin protein that is important for genome stability, and is essential for the assembly of HMGB1 on chromatin. BS-DRL1 mediated DDR exhibits cell-type specificity in the cortex and cerebellum in gamma-irradiated mice and BS-DRL1 knockout mice show impaired motor function and concomitant purkinje cell degeneration. Our study extends the understanding of lncRNAs in DDR and genome stability and implies a protective role of lncRNA against neurodegeneration.Entities:
Year: 2021 PMID： 34210972 DOI： 10.1038/s41467-021-24236-z
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 14.919