M L Hibert1, Y I Chen1,2, N Ohringer1, W J Feuer3, N K Waheed4, J S Heier5, M W Calhoun6, P J Rosenfeld3, J R Polimeni7,2,8. 1. From the Athinoula A. Martinos Center for Biomedical Imaging (M.L.H., Y.I.C., N. O., J.R.P.), Massachusetts General Hospital, Charlestown, Massachusetts. 2. Department of Radiology (Y.I.C., J.R.P.), Harvard Medical School, Boston, Massachusetts. 3. Department of Ophthalmology (W.J.F., P.J.R.), Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida. 4. New England Eye Center (N.K.W.), Tufts Medical Center, Boston, Massachusetts. 5. Ophthalmic Consultants of Boston (J.S.H.), Boston, Massachusetts. 6. OcuDyne Inc (M.W.C.), Roseville, Minnesota. 7. From the Athinoula A. Martinos Center for Biomedical Imaging (M.L.H., Y.I.C., N. O., J.R.P.), Massachusetts General Hospital, Charlestown, Massachusetts jonp@nmr.mgh.harvard.edu. 8. Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology (J.R.P.), Massachusetts Institute of Technology, Cambridge, Massachusetts.
Abstract
BACKGROUND AND PURPOSE: Age-related macular degeneration is associated with reduced perfusion of the eye; however, the role of altered blood flow in the upstream ophthalmic or internal carotid arteries is unclear. We used ultra-high-field MR imaging to investigate whether the diameter of and blood flow in the ophthalmic artery and/or the ICA are altered in age-related macular degeneration and whether any blood flow changes are associated with disease progression. MATERIALS AND METHODS: Twenty-four patients with age-related macular degeneration and 13 similarly-aged healthy controls participated. TOF and high-resolution dynamic 2D phase-contrast MRA (0.26 × 0.26 × 2mm3, 100-ms effective sampling rate) was acquired at 7T. Vessel diameters were calculated from cross-sectional areas in phase-contrast acquisitions. Blood flow time-series were measured across the cardiac cycle. RESULTS: The ophthalmic artery vessel diameter was found to be significantly smaller in patients with age-related macular degeneration than in controls. Volumetric flow through the ophthalmic artery was significantly lower in patients with late age-related macular degeneration, with a significant trend of decreasing volumetric ophthalmic artery flow rates with increasing disease severity. The resistance index was significantly greater in patients with age-related macular degeneration than in controls in the ophthalmic artery. Flow velocity through the ophthalmic artery and ICA was significantly higher in patients with age-related macular degeneration. Ophthalmic artery blood flow as a percentage of ipsilateral ICA blood flow was nearly double in controls than in patients with age-related macular degeneration. CONCLUSIONS: These findings support the hypothesis that vascular changes upstream to the eye are associated with the severity of age-related macular degeneration. Additional investigation into the potential causality of this relationship and whether treatments that improve ocular circulation slow disease progression is warranted.
BACKGROUND AND PURPOSE: Age-related macular degeneration is associated with reduced perfusion of the eye; however, the role of altered blood flow in the upstream ophthalmic or internal carotid arteries is unclear. We used ultra-high-field MR imaging to investigate whether the diameter of and blood flow in the ophthalmic artery and/or the ICA are altered in age-related macular degeneration and whether any blood flow changes are associated with disease progression. MATERIALS AND METHODS: Twenty-four patients with age-related macular degeneration and 13 similarly-aged healthy controls participated. TOF and high-resolution dynamic 2D phase-contrast MRA (0.26 × 0.26 × 2mm3, 100-ms effective sampling rate) was acquired at 7T. Vessel diameters were calculated from cross-sectional areas in phase-contrast acquisitions. Blood flow time-series were measured across the cardiac cycle. RESULTS: The ophthalmic artery vessel diameter was found to be significantly smaller in patients with age-related macular degeneration than in controls. Volumetric flow through the ophthalmic artery was significantly lower in patients with late age-related macular degeneration, with a significant trend of decreasing volumetric ophthalmic artery flow rates with increasing disease severity. The resistance index was significantly greater in patients with age-related macular degeneration than in controls in the ophthalmic artery. Flow velocity through the ophthalmic artery and ICA was significantly higher in patients with age-related macular degeneration. Ophthalmic artery blood flow as a percentage of ipsilateral ICA blood flow was nearly double in controls than in patients with age-related macular degeneration. CONCLUSIONS: These findings support the hypothesis that vascular changes upstream to the eye are associated with the severity of age-related macular degeneration. Additional investigation into the potential causality of this relationship and whether treatments that improve ocular circulation slow disease progression is warranted.
Authors: T A Ciulla; A Harris; H S Chung; R P Danis; L Kagemann; L McNulty; L M Pratt; B J Martin Journal: Am J Ophthalmol Date: 1999-07 Impact factor: 5.258
Authors: Juan E Grunwald; Tatyana I Metelitsina; Joan C Dupont; Gui-Shuang Ying; Maureen G Maguire Journal: Invest Ophthalmol Vis Sci Date: 2005-03 Impact factor: 4.799
Authors: Tatyana I Metelitsina; Juan E Grunwald; Joan C DuPont; Gui-Shuang Ying; Alexander J Brucker; Joshua L Dunaief Journal: Invest Ophthalmol Vis Sci Date: 2008-01 Impact factor: 4.799
Authors: G Chaine; A Hullo; J Sahel; G Soubrane; M A Espinasse-Berrod; D Schutz; C Bourguignon; C Harpey; Y Brault; M Coste; D Moccatti; H Bourgeois Journal: Br J Ophthalmol Date: 1998-09 Impact factor: 4.638
Authors: Anna C Stamm; Chadwick L Wright; Michael V Knopp; Petra Schmalbrock; Johannes T Heverhagen Journal: Magn Reson Imaging Date: 2012-12-05 Impact factor: 2.546
Authors: Agnes Boltz; Alexandra Luksch; Barbara Wimpissinger; Noemi Maar; Günther Weigert; Sophie Frantal; Werner Brannath; Gerhard Garhöfer; Erdem Ergun; Michael Stur; Leopold Schmetterer Journal: Invest Ophthalmol Vis Sci Date: 2010-05-19 Impact factor: 4.799
Authors: Wan Ling Wong; Xinyi Su; Xiang Li; Chui Ming G Cheung; Ronald Klein; Ching-Yu Cheng; Tien Yin Wong Journal: Lancet Glob Health Date: 2014-01-03 Impact factor: 26.763
Authors: Ivan Lylyk; Carlos Bleise; Pedro N Lylyk; Nicolas Perez; Javier Lundquist; Esteban Scrivano; Anibal A Francone; Martin Charles; Tamara Zompa; Pedro Lylyk Journal: J Neurointerv Surg Date: 2022-01-05 Impact factor: 8.572