Literature DB >> 34192471

Low radiation dose to treat pneumonia and other inflammations.

Ming Tsuey Chew1, Eman Daar2,3, Mayeen Uddin Khandaker1, Bleddyn Jones4, Andrew Nisbet5, David A Bradley1,3.   

Abstract

Infection, the invasion of pathogenic microorganisms and viruses, causes reactive inflammation mediated by endogenous signals, with influx of leucocytes with distinct properties and capable of mounting a cellular or antibody response. Different forms of inflammation may also occur in response to tumours, in allergy and autoimmune disorders. Pneumonia, respiratory tract infection and septic shock for instance can arise as serious complications of the Covid-19 virus. While radiotherapy has been most widely used to control malignant tumours, it has also been used for treatment of non-malignant diseases, including acute and chronic inflammation in situations where anti-inflammatory drugs may be ineffective or contraindicated. The present review examines the history and prospects for low-dose anti-inflammatory radiation treatments, the present interest largely being motivated by the increased incidence of pulmonary disease associated Covid-19 infections. Evidence in support of the suggested efficacy are covered, together with an appraisal of one of the number of potential convenient sources that could complement external beam arrangements.

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Year:  2021        PMID: 34192471      PMCID: PMC8764926          DOI: 10.1259/bjr.20201265

Source DB:  PubMed          Journal:  Br J Radiol        ISSN: 0007-1285            Impact factor:   3.629


  40 in total

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Journal:  Ann ICRP       Date:  2007

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Authors:  D H Brand; J R Yarnold
Journal:  Clin Oncol (R Coll Radiol)       Date:  2019-07-05       Impact factor: 4.126

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Journal:  Ann ICRP       Date:  2012

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Journal:  Ann ICRP       Date:  1994

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Authors:  D V Bates; B R Fish; T F Hatch; T T Mercer; P E Morrow
Journal:  Health Phys       Date:  1966-02       Impact factor: 1.316

Review 7.  Radiotherapy treatment of human inflammatory diseases and conditions: Optimal dose.

Authors:  E J Calabrese; G Dhawan; R Kapoor; W J Kozumbo
Journal:  Hum Exp Toxicol       Date:  2019-05-06       Impact factor: 2.903

8.  How radiotherapy was historically used to treat pneumonia: could it be useful today?

Authors:  Edward J Calabrese; Gaurav Dhawan
Journal:  Yale J Biol Med       Date:  2013-12-13

Review 9.  Health Impacts of Low-Dose Ionizing Radiation: Current Scientific Debates and Regulatory Issues.

Authors:  Alexander Vaiserman; Alexander Koliada; Oksana Zabuga; Yehoshua Socol
Journal:  Dose Response       Date:  2018-09-19       Impact factor: 2.658

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