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Literature DB >> 34191267

Ischemic Stroke and Sleep: The Linking Genetic Factors.

Abstract

This review summarizes the available data about genetic factors which can link ischemic stroke and sleep. Sleep patterns (subjective and objective measures) are characterized by heritability and comprise up to 38-46%. According to Mendelian randomization analysis, genetic liability for short sleep duration and frequent insomnia symptoms is associated with ischemic stroke (predominantly of large artery subtype). The potential genetic links include variants of circadian genes, genes encoding components of neurotransmitter systems, common cardiovascular risk factors, as well as specific genetic factors related to certain sleep disorders.

Entities: Disease

Keywords: Cardiovascular prevention; Cardiovascular risk; Cerebrovascular disease; Circadian rhythms; Clock genes; Genetics; Ischemia–reperfusion; Ischemic stroke; Sleep; Sleep disorders

Year: 2021 PMID： 34191267 DOI： 10.1007/s40119-021-00231-9

Source DB: PubMed Journal: Cardiol Ther ISSN： 2193-6544

135 in total

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