Changlin Li1, Haixia Guan2,3, Qiao He4, Yishen Zhao1, Nan Liang1, Jiao Zhang1, Gianlorenzo Dionigi5, Hui Sun6. 1. Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun, Jilin Province, China. 2. Department of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, 106 Zhongshan Er Road, Guangzhou, Guangdong, P. R. China. 3. The Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, P. R. China. 4. Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China. 5. Division for Endocrine and Minimally Invasive Surgery, Department of Human Pathology in Adulthood and Childhood "G. Barresi,", University Hospital G. Martino, University of Messina, Via C. Valeria 1, Messina, Italy. gdionigi@unime.it. 6. Division of Thyroid Surgery, China-Japan Union Hospital of Jilin University, Jilin Provincial Key Laboratory of Surgical Translational Medicine, Jilin Provincial Engineering Laboratory of Thyroid Disease Prevention and Control, Changchun, Jilin Province, China. s_h@jlu.edu.cn.
Abstract
OBJECTIVE: To explore the relationship between triglyceride (TG) levels and aggressive pathological characteristics in papillary thyroid microcarcinoma (PTMC) patients, especially the relationship between TG, BMI, age, and extrathyroidal extension (ETE). METHODS: A retrospective analysis of 9663 patients with PTMC in a single center from 2010 to 2017 was included in this study. Binary logistic regression was used to analyze the relationship between serum TG and aggressive pathological characteristics of PTMC in different genders. Further analyzing the risk of high TG in different ages and BMI groups. RESULTS: Even after adjustment for confounding factors, high TG is still a risk factor for ETE in women with PTMC, but not a risk factor for men. Compared with the group with lower than 0.90 mmol/L, when the TG level is higher than 1.93 mmol/L, the risk of ETE in women increased by about 1.35-fold. The remaining two variables (BMI, age) as risk factors for ETE are analyzed. In the normal BMI group, high TG is still a risk factor for ETE. The risk of ETE in women more than 55 years old is significantly increased by 1.96-fold (1.34-fold in less than 55 years). CONCLUSION: High TG in women is positively correlated with the risk of ETE in PTMC. PTMC with high TG in elderly women (more than 55 years) has a higher risk of ETE. TG is a potential serological index for predicting the risk of ETE in women with normal BMI.
OBJECTIVE: To explore the relationship between triglyceride (TG) levels and aggressive pathological characteristics in papillary thyroid microcarcinoma (PTMC) patients, especially the relationship between TG, BMI, age, and extrathyroidal extension (ETE). METHODS: A retrospective analysis of 9663 patients with PTMC in a single center from 2010 to 2017 was included in this study. Binary logistic regression was used to analyze the relationship between serum TG and aggressive pathological characteristics of PTMC in different genders. Further analyzing the risk of high TG in different ages and BMI groups. RESULTS: Even after adjustment for confounding factors, high TG is still a risk factor for ETE in women with PTMC, but not a risk factor for men. Compared with the group with lower than 0.90 mmol/L, when the TG level is higher than 1.93 mmol/L, the risk of ETE in women increased by about 1.35-fold. The remaining two variables (BMI, age) as risk factors for ETE are analyzed. In the normal BMI group, high TG is still a risk factor for ETE. The risk of ETE in women more than 55 years old is significantly increased by 1.96-fold (1.34-fold in less than 55 years). CONCLUSION: High TG in women is positively correlated with the risk of ETE in PTMC. PTMC with high TG in elderly women (more than 55 years) has a higher risk of ETE. TG is a potential serological index for predicting the risk of ETE in women with normal BMI.
Authors: J-C Riss; I Peyrottes; E Chamorey; J Haudebourg; A Sudaka; D Benisvy; P-Y Marcy; E-E-M Nao; F Demard; J Vallicioni; G Poissonnet; O Dassonville; J Santini; A Bozec Journal: Eur Ann Otorhinolaryngol Head Neck Dis Date: 2012-04-03 Impact factor: 2.080
Authors: Draženka Janković; Peter Wolf; Christian-Heinz Anderwald; Yvonne Winhofer; Miriam Promintzer-Schifferl; Astrid Hofer; Felix Langer; Gerhard Prager; Bernhard Ludvik; Alois Gessl; Anton Luger; Michael Krebs Journal: Obes Surg Date: 2012-01 Impact factor: 4.129