Hidetaka Uramoto1, Tomoya Takiguchi2, Tomonobu Koizumi3, Azusa Tanimoto4, Ryuji Hayashi5, Yozo Nakazawa6, Ken-Ichi Ito7, Mitsutoshi Nakada8, Yasuo Hirono9, Yoshikazu Nishino2, Seiji Yano4. 1. Department of Thoracic Surgery, Kanazawa Medical University, Kahoku, Japan. hidetaka@kanazawa-med.ac.jp. 2. Department of Epidemiology and Public Health, Kanazawa Medical University, Kahoku, Japan. 3. Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, Matsumoto, Japan. 4. Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. 5. Department of Clinical Oncology, Toyama University Hospital, Toyama, Japan. 6. Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan. 7. Division of Breast and Endocrine Surgery, Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan. 8. Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan. 9. Cancer Care Promotion Center, University of Fukui Hospital, Fukui, Japan.
Abstract
BACKGROUND: Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region. METHODS: We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals. RESULTS: A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients CONCLUSION: MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy.
BACKGROUND: Malignant pleural mesothelioma (MPM) is a major occupational and environmental neoplasm. The purpose of this study was to validate the clinical and epidemiological factors, diagnosis, and initial treatment among MPM patients in the Hokushin region. METHODS: We surveyed retrospective data from 152,921 cancer patients in 22 principal hospitals. RESULTS: A total of 166 MPM cases were newly diagnosed. These patients consisted of 136 men and 30 women, with a median age of 69 years. We estimated the incidence rate for MPM to be 0.55 cases per 100,000 person-years in this study. The ratio per 100,000 population-years was 0.39 in Fukui, 0.60 in Ishikawa, 1.02 in Toyama and 0.35 in Nagano. Forty-five patients were discovered when diagnosed incidentally in patients under observations for other diseases. Forty-six cases were diagnosed as localized disease, while 13 had accompanying regional lymph node metastasis. Furthermore, 44 cases showed infiltration into adjacent organs. A histo-cytological diagnosis was made in 164 cases (98.8%). A surgical approach, chemotherapy, and radiotherapy were performed for 33, 88, and 6 patients, respectively, while 44 patients (26.5%) received best supportive care. Multimodality therapy was conducted in just 3.0% of the MPM patients CONCLUSION: MPM has a tragically rapid progression if discovered under observations for other diseases. Workers in health-related fields should be on high alert for aggressive MPM. Better evaluation and multi-disciplinary approaches to MPM in these regions are needed to optimize multimodality therapy.
Authors: B C John Cho; Laura Donahoe; Penelope A Bradbury; Natasha Leighl; Shaf Keshavjee; Andrew Hope; Prodipto Pal; Michael Cabanero; Kasia Czarnecka; Karen McRae; Ming-Sound Tsao; Marc de Perrot Journal: Lancet Oncol Date: 2021-01-12 Impact factor: 41.316
Authors: S Jane Henley; Theodore C Larson; Manxia Wu; Vinicius C S Antao; Mary Lewis; Germania A Pinheiro; Christie Eheman Journal: Int J Occup Environ Health Date: 2013 Jan-Mar