Literature DB >> 34181706

Immunological Correlates of the HIV-1 Replication-Competent Reservoir Size.

Sherazaan D Ismail1, Catherine Riou1,2, Sarah B Joseph3,4, Nancie M Archin5, David M Margolis3,5, Alan S Perelson6, Tyler Cassidy6, Melissa-Rose Abrahams1, Matthew Moeser4, Olivia D Council4, Lyle R McKinnon7,8, Farzana Osman7, Quarraisha Abdool Karim7,9, Salim S Abdool Karim7,9, Ronald Swanstrom3,10, Carolyn Williamson1,2,7, Nigel J Garrett7,11, Wendy A Burgers1,2.   

Abstract

Understanding what shapes the latent human immunodeficiency virus type 1 (HIV-1) reservoir is critical for developing strategies for cure. We measured frequency of persistent HIV-1 infection after 5 years of suppressive antiretroviral therapy initiated during chronic infection. Pretreatment CD8+ T-cell activation, nadir CD4 count, and CD4:CD8 ratio predicted reservoir size.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  HIV-1; T-cell activation; replication-competent virus; reservoir

Mesh：

Substances：

Year:  2021        PMID： 34181706      PMCID： PMC8528395          DOI： 10.1093/cid/ciab587

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   20.999


  18 in total

1.  Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells.

Authors:  Janet D Siliciano; Joleen Kajdas; Diana Finzi; Thomas C Quinn; Karen Chadwick; Joseph B Margolick; Colin Kovacs; Stephen J Gange; Robert F Siliciano
Journal:  Nat Med       Date:  2003-05-18       Impact factor: 53.440

2.  Enhanced culture assay for detection and quantitation of latently infected, resting CD4+ T-cells carrying replication-competent virus in HIV-1-infected individuals.

Authors:  Janet D Siliciano; Robert F Siliciano
Journal:  Methods Mol Biol       Date:  2005

3.  SLDAssay: A software package and web tool for analyzing limiting dilution assays.

Authors:  Ilana M Trumble; Andrew G Allmon; Nancie M Archin; Joseph Rigdon; Owen Francis; Pedro L Baldoni; Michael G Hudgens
Journal:  J Immunol Methods       Date:  2017-07-18       Impact factor: 2.303

4.  Augmentation of HIV-specific T cell function by immediate treatment of hyperacute HIV-1 infection.

Authors:  Zaza M Ndhlovu; Samuel W Kazer; Thandeka Nkosi; Funsho Ogunshola; Daniel M Muema; Gursev Anmole; Shayda A Swann; Amber Moodley; Krista Dong; Tarylee Reddy; Mark A Brockman; Alex K Shalek; Thumbi Ndung'u; Bruce D Walker
Journal:  Sci Transl Med       Date:  2019-05-22       Impact factor: 17.956

5.  Longitudinal Dynamics of Intact HIV Proviral DNA and Outgrowth Virus Frequencies in a Cohort of Individuals Receiving Antiretroviral Therapy.

Authors:  Shane D Falcinelli; Kayla W Kilpatrick; Jenna Read; Ross Murtagh; Brigitte Allard; Simon Ghofrani; Jennifer Kirchherr; Katherine S James; Erin Stuelke; Caroline Baker; JoAnn D Kuruc; Joseph J Eron; Michael G Hudgens; Cynthia L Gay; David M Margolis; Nancie M Archin
Journal:  J Infect Dis       Date:  2021-07-02       Impact factor: 5.226

6.  The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation.

Authors:  Melissa-Rose Abrahams; Sarah B Joseph; Nigel Garrett; Lynn Tyers; Matthew Moeser; Nancie Archin; Olivia D Council; David Matten; Shuntai Zhou; Deelan Doolabh; Colin Anthony; Nilu Goonetilleke; Salim Abdool Karim; David M Margolis; Sergei Kosakovsky Pond; Carolyn Williamson; Ronald Swanstrom
Journal:  Sci Transl Med       Date:  2019-10-09       Impact factor: 17.956

Review 7.  Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage.

Authors:  Reena Rajasuriar; Edwina Wright; Sharon R Lewin
Journal:  Curr Opin HIV AIDS       Date:  2015-01       Impact factor: 4.283

8.  Reduced HIV-1 latent reservoir outgrowth and distinct immune correlates among women in Rakai, Uganda.

Authors:  Jessica L Prodger; Adam A Capoferri; Katherine Yu; Jun Lai; Steven J Reynolds; Jingo Kasule; Taddeo Kityamuweesi; Paul Buule; David Serwadda; Kyungyoon J Kwon; Katherine Schlusser; Craig Martens; Eileen Scully; Yun-Hee Choi; Andrew D Redd; Thomas C Quinn
Journal:  JCI Insight       Date:  2020-07-23

9.  An altered cytotoxic program of CD8+ T-cells in HIV-infected patients despite HAART-induced viral suppression.

Authors:  Federico Perdomo-Celis; Paula A Velilla; Natalia A Taborda; María Teresa Rugeles
Journal:  PLoS One       Date:  2019-01-09       Impact factor: 3.240

10.  Levels of Human Immunodeficiency Virus DNA Are Determined Before ART Initiation and Linked to CD8 T-Cell Activation and Memory Expansion.

Authors:  Genevieve E Martin; Matthew Pace; Freya M Shearer; Eva Zilber; Jacob Hurst; Jodi Meyerowitz; John P Thornhill; Julianne Lwanga; Helen Brown; Nicola Robinson; Emily Hopkins; Natalia Olejniczak; Nneka Nwokolo; Julie Fox; Sarah Fidler; Christian B Willberg; John Frater
Journal:  J Infect Dis       Date:  2020-03-16       Impact factor: 5.226
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  2 in total

1.  CCL5-Secreting Virtual Memory CD8+ T Cells Inversely Associate With Viral Reservoir Size in HIV-1-Infected Individuals on Antiretroviral Therapy.

Authors:  Wei Hu; Yan-Jun Li; Cheng Zhen; You-Yuan Wang; Hui-Huang Huang; Jun Zou; Yan-Qing Zheng; Gui-Chan Huang; Si-Run Meng; Jie-Hua Jin; Jing Li; Ming-Ju Zhou; Yu-Long Fu; Peng Zhang; Xiao-Yu Li; Tao Yang; Xiu-Wen Wang; Xiu-Han Yang; Jin-Wen Song; Xing Fan; Yan-Mei Jiao; Ruo-Nan Xu; Ji-Yuan Zhang; Chun-Bao Zhou; Jin-Hong Yuan; Lei Huang; Ya-Qin Qin; Feng-Yao Wu; Ming Shi; Fu-Sheng Wang; Chao Zhang
Journal:  Front Immunol       Date:  2022-05-26       Impact factor: 8.786

Review 2.  HIV-Related Immune Activation and Inflammation: Current Understanding and Strategies.

Authors:  Tingxia Lv; Wei Cao; Taisheng Li
Journal:  J Immunol Res       Date:  2021-09-29       Impact factor: 4.818
  2 in total

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