| Literature DB >> 12754504 |
Janet D Siliciano1, Joleen Kajdas, Diana Finzi, Thomas C Quinn, Karen Chadwick, Joseph B Margolick, Colin Kovacs, Stephen J Gange, Robert F Siliciano.
Abstract
Latent HIV-1 persists in resting memory CD4+ T cells, even in patients receiving highly active antiretroviral therapy (HAART). It has been unclear how stable this latent reservoir is and whether its persistence reflects replenishment by low-level viremia. Here we show that even in treated patients who have had no detectable viremia for as long as 7 years, the reservoir decays so slowly (t(1/2) = 44 months) that eradication is unlikely.Entities:
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Year: 2003 PMID： 12754504 DOI： 10.1038/nm880
Source DB: PubMed Journal: Nat Med ISSN： 1078-8956 Impact factor: 53.440