Literature DB >> 34181473

Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species.

Nawarat Somprasong1, Jinhee Yi1, Carina M Hall1, Jessica R Webb2, Jason W Sahl1, David M Wagner1, Paul Keim1, Bart J Currie2,3, Herbert P Schweizer1.   

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Entities:  

Keywords:  Burkholderia; RND efflux pumps; multidrug resistance

Mesh：

Substances：

Year:  2021        PMID： 34181473      PMCID： PMC8370192          DOI： 10.1128/AAC.00920-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  47 in total

1.  Exposing the third chromosome of Burkholderia cepacia complex strains as a virulence plasmid.

Authors:  K Agnoli; S Schwager; S Uehlinger; A Vergunst; D F Viteri; D T Nguyen; P A Sokol; A Carlier; L Eberl
Journal:  Mol Microbiol       Date:  2011-12-16       Impact factor: 3.501

Review 2.  Mechanisms of antibiotic resistance in Burkholderia pseudomallei: implications for treatment of melioidosis.

Authors:  Herbert P Schweizer
Journal:  Future Microbiol       Date:  2012-12       Impact factor: 3.165

3.  Efflux-mediated aminoglycoside and macrolide resistance in Burkholderia pseudomallei.

Authors:  R A Moore; D DeShazer; S Reckseidler; A Weissman; D E Woods
Journal:  Antimicrob Agents Chemother       Date:  1999-03       Impact factor: 5.191

4.  The BpeEF-OprC efflux pump is responsible for widespread trimethoprim resistance in clinical and environmental Burkholderia pseudomallei isolates.

Authors:  Nicole L Podnecky; Vanaporn Wuthiekanun; Sharon J Peacock; Herbert P Schweizer
Journal:  Antimicrob Agents Chemother       Date:  2013-07-01       Impact factor: 5.191

5.  Interplay between three RND efflux pumps in doxycycline-selected strains of Burkholderia thailandensis.

Authors:  Fabrice Vincent Biot; Mélanie Monique Lopez; Thomas Poyot; Fabienne Neulat-Ripoll; Sabrina Lignon; Arnaud Caclard; François Michel Thibault; Andre Peinnequin; Jean-Marie Pagès; Eric Valade
Journal:  PLoS One       Date:  2013-12-27       Impact factor: 3.240

6.  Efflux pump-mediated drug resistance in Burkholderia.

Authors:  Nicole L Podnecky; Katherine A Rhodes; Herbert P Schweizer
Journal:  Front Microbiol       Date:  2015-04-14       Impact factor: 5.640

7.  Genomic analyses of Burkholderia cenocepacia reveal multiple species with differential host-adaptation to plants and humans.

Authors:  Adrian Wallner; Eoghan King; Eddy L M Ngonkeu; Lionel Moulin; Gilles Béna
Journal:  BMC Genomics       Date:  2019-11-04       Impact factor: 3.969

8.  Assessment of three Resistance-Nodulation-Cell Division drug efflux transporters of Burkholderia cenocepacia in intrinsic antibiotic resistance.

Authors:  Silvia Buroni; Maria R Pasca; Ronald S Flannagan; Silvia Bazzini; Anna Milano; Iris Bertani; Vittorio Venturi; Miguel A Valvano; Giovanna Riccardi
Journal:  BMC Microbiol       Date:  2009-09-17       Impact factor: 3.605

9.  The Burkholderia Genome Database: facilitating flexible queries and comparative analyses.

Authors:  Geoffrey L Winsor; Bhavjinder Khaira; Thea Van Rossum; Raymond Lo; Matthew D Whiteside; Fiona S L Brinkman
Journal:  Bioinformatics       Date:  2008-10-07       Impact factor: 6.937

10.  The Effects of Signal Erosion and Core Genome Reduction on the Identification of Diagnostic Markers.

Authors:  Jason W Sahl; Adam J Vazquez; Carina M Hall; Joseph D Busch; Apichai Tuanyok; Mark Mayo; James M Schupp; Madeline Lummis; Talima Pearson; Kenzie Shippy; Rebecca E Colman; Christopher J Allender; Vanessa Theobald; Derek S Sarovich; Erin P Price; Alex Hutcheson; Jonas Korlach; John J LiPuma; Jason Ladner; Sean Lovett; Galina Koroleva; Gustavo Palacios; Direk Limmathurotsakul; Vanaporn Wuthiekanun; Gumphol Wongsuwan; Bart J Currie; Paul Keim; David M Wagner
Journal:  mBio       Date:  2016-09-20       Impact factor: 7.867
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