Literature DB >> 34178825

Polymorphic genetic markers and how they are associated with clinical and metabolic indicators of type 2 diabetes mellitus in the Kazakh population.

Valeriy V Benberin1, Tamara A Vochshenkova2, Gulshara Zh Abildinova2, Anna V Borovikova2, Almagul A Nagimtayeva2.   

Abstract

BACKGROUND: Type 2 diabetes mellitus is a serious public health problem worldwide. The aim of the study was to analyze the relationship of eight polymorphic gene variants with the development of clinical-metabolic rates of type 2 diabetes mellitus inside Kazakh population.
MATERIALS AND METHODS: 139 patients with type 2 diabetes mellitus and 100 patients in the control group were examined. Genotyping of polymorphisms of candidate genes was carried out on a next generation QuantStudio 12 K Flex unit.
RESULTS: Gene TCF7L2 locus rs7901695 and rs7903146, gene KCNQ1 locus rs2237892, rs7756992, and gene CDKAL1 locus rs7754840 demonstrated statistically significant associations with glucose metabolism, lipid profile and body mass index (BMI) in type 2 DM inside the population. Statistically significant difference in anthropometric and biochemical measures of rs17584499, rs4712523 and rs163184 has not been revealed.
CONCLUSIONS: Genetic polymorphisms that influence pancreatic gland beta-cells insulin release and secretion associate with metabolic and anthropometric measures definitive for type 2 DM in Kazakh population. © Springer Nature Switzerland AG 2021.

Entities:  

Keywords:  Gene; Genetic predisposition; Genetic typing; SNP (single nucleotide polymorphism); T2DM (type 2 diabetes mellitus)

Year:  2021        PMID： 34178825      PMCID： PMC8212330          DOI： 10.1007/s40200-020-00720-z

Source DB:  PubMed          Journal:  J Diabetes Metab Disord        ISSN： 2251-6581


  38 in total

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