| Literature DB >> 34174846 |
Alexander M Keppler1, Konstantin Küßner1, Anna-Lena Schulze1, Eduardo M Suero1, Carl Neuerburg1, Maximilian Weigert2, Christian Braun3, Wolfgang Böcker1, Christian Kammerlander1, Christian Zeckey4,5.
Abstract
AIM: The treatment of tibial fractures with an intramedullary nail is an established procedure. However, torsional control remains challenging using intraoperatively diagnostic tools. Radiographic tools such as the Cortical Step Sign (CSS) and the Diameter Difference Sign (DDS) may serve as tools for diagnosing a relevant malrotation. The aim of this study was to investigate the effect of torsional malalignment on CSS and DDS parameters and to construct a prognostic model to detect malalignment.Entities:
Keywords: Cortical step sign; Diameter difference sign; Intramedullary nailing; Rotational malalignment; Tibial shaft fracture
Mesh:
Year: 2021 PMID: 34174846 PMCID: PMC8236139 DOI: 10.1186/s12891-021-04452-w
Source DB: PubMed Journal: BMC Musculoskelet Disord ISSN: 1471-2474 Impact factor: 2.362
Diameter of each Tibia specimen at the osteotomy site in the anteroposterior (AP) and lateral (Lat) radiographic views
| Diameter AP | Diameter Lat | |
|---|---|---|
| 1 | 31.3 | 42.2 |
| 2 | 34.5 | 35.9 |
| 3 | 32 | 34.3 |
| 4 | 35.7 | 36.7 |
| 5 | 25.1 | 29.2 |
| 6 | 31.1 | 36.6 |
| 7 | 23.5 | 30.7 |
| 8 | 30.3 | 40.4 |
| 9 | 28.7 | 37.7 |
| 10 | 30.2 | 36.7 |
| 11 | 28.5 | 43.5 |
| 12 | 37.1 | 35.8 |
| 13 | 29 | 34.5 |
| 14 | 31.4 | 34.7 |
| 15 | 29.7 | 37.3 |
| 16 | 27.2 | 31.6 |
| 17 | 29.2 | 38.4 |
| 18 | 31.3 | 37.1 |
| 19 | 25.7 | 31.6 |
| 30.1 | 36 | |
| 3.4 | 3.7 |
Fig. 1Experimental setup with K-wires to control torsional alignment of the tibial shaft
Fig. 2View of the different torsions in AP view. A: 20° external torsion B: 0° (neutral position) C: 20° internal torsion. # = Tibial shaft diameter (TD); * = Lateral cortical thickness (LCT), ** = Medial cortical thickness (MCT)
Absolute Differences in External Torsion, Anteroposterior View
| 0° | 5° | 10° | 15° | 20° | 25° | 30° | p-Value | |
|---|---|---|---|---|---|---|---|---|
| Medial Cortical Thickness | ||||||||
| MCT Mean | 0.1 mm | 0.4 mm | 0.8 mm | 1.04 mm | 1.27 mm | 1.61 mm | 1.99 mm | < 0.001 |
| MCT SD | 0.13 mm | 0.4 mm | 0.76 mm | 0.84 mm | 0.85 mm | 0.94 mm | 1.42 mm | |
| MCT Visibility1 | 0% | 15.79% | 47.37% | 57.89% | 68.42% | 84.21% | 68.42% | |
| MCT Pos. Difference1 | 31.58% | 36.84% | 26.32% | 15.79% | 21.05% | 21.05% | 21.05% | |
| LCT Mean | 0.15 mm | 1.29 mm | 2.27 mm | 2.95 mm | 3.64 mm | 4.19 mm | 4.4 mm | < 0.001 |
| LCT SD | 0.23 mm | 1.11 mm | 1.29 mm | 1.51 mm | 1.84 mm | 1.97 mm | 2.1 mm | |
| LCT Visibility1 | 10.53% | 68.42% | 89.47% | 100% | 100% | 100% | 100% | |
| LCT Pos. Difference2 | 47.37% | 5.26% | 0% | 0% | 0% | 0% | 0% | |
| Dia.ap Mean | 0.81 mm | 1.59 mm | 2.52 mm | 3.88 mm | 5.06 mm | 5.64 mm | 6.02 mm | < 0.001 |
| Dia.ap SD | 0.83 mm | 1.07 mm | 1.35 mm | 1.67 mm | 1.87 mm | 2.04 mm | 2.61 mm | |
| Dia.ap Visibility1 | 47.37% | 78.95% | 94.74% | 100% | 100% | 100% | 100% | |
| Dia.ap Pos. Difference2 | 63.16% | 31.58% | 10.53% | 5.26% | 5.26% | 5.26% | 10.53% | |
1 Visibility is given if the absolute difference exceeds 0.6 mm
2 A positive difference is equivalent to a greater proximal value compared to the distal value
Fig. 3The influence of torsion on the visibility (0.6 mm) of individual parameter. The negative values reflect internal torsion, positive values reflect external torsion
Absolute Differences in External Torsion, Lateral View
| 0° | 5° | 10° | 15° | 20° | 25° | 30° | p-Value | |
|---|---|---|---|---|---|---|---|---|
| Anterior Cortical Thickness | ||||||||
| ACT Mean | 0.38 mm | 0.89 mm | 1.21 mm | 1.62 mm | 2.37 mm | 2.95 mm | 3.22 mm | < 0.001 |
| ACT SD | 0.94 mm | 0.83 mm | 0.88 mm | 1.28 mm | 1.51 mm | 1.74 mm | 1.81 mm | |
| ACT Visibility | 15.79% | 57.89% | 68.42% | 73.68% | 89.47% | 94.74% | 89.47% | |
| ACT Pos. Difference | 36.84% | 63.16% | 68.42% | 78.95% | 89.47% | 89.47% | 84.21% | |
| PCT Mean | 0.17 mm | 0.44 mm | 0.71 mm | 0.83 mm | 1 mm | 1.2 mm | 1.42 mm | < 0.001 |
| PCT SD | 0.32 mm | 0.38 mm | 0.54 mm | 0.67 mm | 0.68 mm | 0.65 mm | 0.8 mm | |
| PCT Visibility | 10.53% | 36.84% | 42.11% | 52.63% | 73.68% | 78.95% | 84.21% | |
| PCT Pos. Difference | 47.37% | 31.58% | 42.11% | 57.89% | 73.68% | 78.95% | 78.95% | |
| Dia.lat Mean | 0.41 mm | 2.05 mm | 3.47 mm | 4.82 mm | 6.31 mm | 7.19 mm | 7.32 mm | < 0.001 |
| Dia.lat SD | 0.52 mm | 0.95 mm | 1.36 mm | 1.6 mm | 1.97 mm | 2.34 mm | 3.19 mm | |
| Dia.lat Visibility | 21.05% | 94.74% | 100% | 100% | 100% | 100% | 94.74% | |
| Dia.lat Pos. Difference | 73.68% | 94.74% | 94.74% | 89.47% | 94.74% | 94.74% | 89.47% | |
1 Visibility is given if the absolute difference exceeds 0.6 mm
2 A positive difference is equivalent to a greater proximal value compared to the distal value
Absolute Differences in Internal Torsion, Anteroposterior View
| 0° | 5° | 10° | 15° | 20° | 25° | 30° | ||
|---|---|---|---|---|---|---|---|---|
| Medial Cortical Thickness | ||||||||
| MCT Mean | 0.1 mm | 0.4 mm | 0.72 mm | 0.67 mm | 0.84 mm | 0.92 mm | 1.03 mm | 0.009 |
| MCT SD | 0.13 mm | 0.5 mm | 0.58 mm | 0.79 mm | 0.96 mm | 0.97 mm | 1.24 mm | |
| MCT Visibility | 0% | 15.79% | 36.84% | 36.84% | 44.44% | 57.89% | 52.63% | |
| MCT Pos. Difference | 31.58% | 42.11% | 57.89% | 57.89% | 55.56% | 47.37% | 52.63% | |
| LCT Mean | 0.15 mm | 0.85 mm | 1.45 mm | 1.52 mm | 1.09 mm | 1.61 mm | 1.84 mm | < 0.001 |
| LCT SD | 0.23 mm | 0.72 mm | 0.86 mm | 0.87 mm | 0.9 mm | 1.2 mm | 1.28 mm | |
| LCT Visibility | 10.53% | 47.37% | 78.95% | 84.21% | 55.56% | 68.42% | 78.95% | |
| LCT Pos. Difference | 47.37% | 57.89% | 57.89% | 63.16% | 50% | 52.63% | 57.89% | |
| Dia.ap Mean | 0.81 mm | 2.12 mm | 2.89 mm | 3.11 mm | 3.63 mm | 3.49 mm | 3.65 mm | < 0.001 |
| Dia.ap SD | 0.83 mm | 1.29 mm | 1.55 mm | 1.74 mm | 1.79 mm | 2.01 mm | 1.99 mm | |
| Dia.ap Visibility | 47.37% | 94.74% | 100% | 89.47% | 94.44% | 94.74% | 94.74% | |
| Dia.ap Pos. Difference | 63.16% | 100% | 94.74% | 94.74% | 94.44% | 89.47% | 89.47% | |
1 Visibility is given if the absolute difference exceeds 0.6 mm
2 A positive difference is equivalent to a greater proximal value compared to the distal value
Absolutes Differences in Internal Torsion, Lateral View
| 0° | 5° | 10° | 15° | 20° | 25° | 30° | p-Value | |
|---|---|---|---|---|---|---|---|---|
| Anterior Cortical Thickness | ||||||||
| ACT Mean | 0.38 mm | 0.75 mm | 1.25 mm | 1.89 mm | 2.13 mm | 2.16 mm | 2.36 mm | < 0.001 |
| ACT SD | 0.94 mm | 0.54 mm | 0.87 mm | 0.94 mm | 1.04 mm | 1.14 mm | 1.41 mm | |
| ACT Visibility | 15.79% | 52.63% | 68.42% | 84.21% | 88.89% | 100% | 89.47% | |
| ACT Pos. Difference | 36.84% | 10.53% | 15.79% | 15.79% | 5.56% | 10.53% | 21.05% | |
| PCT Mean | 0.17 mm | 0.78 mm | 1.08 mm | 1.65 mm | 1.85 mm | 1.85 mm | 1.78 mm | < 0.001 |
| PCT SD | 0.32 mm | 0.74 mm | 0.98 mm | 1.07 mm | 1.14 mm | 1.35 mm | 1.04 mm | |
| PCT Visibility | 10.53% | 47.37% | 63.16% | 73.68% | 88.89% | 84.21% | 78.95% | |
| PCT Pos. Difference | 47.37% | 21.05% | 15.79% | 10.53% | 11.11% | 5.26% | 15.79% | |
| Dia.lat Mean | 0.41 mm | 1.16 mm | 2.15 mm | 2.85 mm | 3.19 mm | 3.18 mm | 3.42 mm | < 0.001 |
| Dia.lat SD | 0.52 mm | 0.69 mm | 1.17 mm | 1.34 mm | 1.79 mm | 1.79 mm | 1.86 mm | |
| Dia.lat Visibility | 21.05% | 73.68% | 89.47% | 100% | 88.89% | 100% | 100% | |
| Dia.lat Pos. Difference | 73.68% | 10.53% | 5.26% | 5.26% | 5.56% | 5.26% | 5.26% | |
1 Visibility is given if the absolute difference exceeds 0.6 mm
2 A positive difference is equivalent to a greater proximal value compared to the distal value
Fig. 4Correlation of absolute radiographic differences and torsional alignment. Upper triangle: External torsion. Lower triangle: Internal torsion
Probability of Tibial maltorsion at each measurement threshold for each of the radiographic variables studied
| Probability | Threshold | PPV | FDR | Sensitivity | Specificity |
|---|---|---|---|---|---|
| Medial Cortical Thickness | ( | ||||
| 0.5 | 1.06 | 0.63 | 0.37 | 0.46 | 0.82 |
| 0.6 | 1.52 | 0.60 | 0.40 | 0.33 | 0.89 |
| 0.7 | 2.02 | 0.68 | 0.32 | 0.24 | 0.94 |
| 0.8 | 2.63 | 0.77 | 0.23 | 0.15 | 0.97 |
| 0.9 | 3.55 | 1.00 | 0.00 | 0.04 | 1.00 |
| 0.5 | 2.42 | 0.55 | 0.45 | 0.49 | 0.77 |
| 0.6 | 3.30 | 0.55 | 0.45 | 0.35 | 0.86 |
| 0.7 | 4.25 | 0.63 | 0.37 | 0.24 | 0.94 |
| 0.8 | 5.42 | 0.91 | 0.09 | 0.13 | 0.99 |
| 0.9 | 7.17 | 1.00 | 0.00 | 0.04 | 1.00 |
| 0.5 | 3.72 | 0.47 | 0.53 | 0.61 | 0.76 |
| 0.6 | 4.47 | 0.60 | 0.40 | 0.51 | 0.87 |
| 0.7 | 5.28 | 0.65 | 0.35 | 0.40 | 0.93 |
| 0.8 | 6.27 | 0.94 | 0.06 | 0.26 | 0.99 |
| 0.9 | 7.76 | 1.00 | 0.00 | 0.06 | 1.00 |
| 0.5 | 1.92 | 0.49 | 0.51 | 0.63 | 0.76 |
| 0.6 | 2.39 | 0.66 | 0.34 | 0.49 | 0.89 |
| 0.7 | 2.90 | 0.86 | 0.14 | 0.36 | 0.94 |
| 0.8 | 3.52 | 0.75 | 0.25 | 0.24 | 0.96 |
| 0.9 | 4.45 | 0.91 | 0.09 | 0.14 | 0.99 |
| 0.5 | 1.30 | 0.59 | 0.41 | 0.51 | 0.75 |
| 0.6 | 1.78 | 0.60 | 0.40 | 0.34 | 0.85 |
| 0.7 | 2.30 | 0.75 | 0.25 | 0.19 | 0.94 |
| 0.8 | 2.94 | 0.48 | 0.52 | 0.06 | 0.97 |
| 0.9 | 3.90 | 0.95 | 0.05 | 0.04 | 1.00 |
| 0.5 | 3.91 | 0.42 | 0.58 | 0.62 | 0.77 |
| 0.6 | 4.77 | 0.52 | 0.48 | 0.52 | 0.88 |
| 0.7 | 5.71 | 0.75 | 0.25 | 0.43 | 0.95 |
| 0.8 | 6.85 | 0.93 | 0.07 | 0.30 | 0.99 |
| 0.9 | 8.57 | 1.00 | 0.00 | 0.13 | 1.00 |
Fig. 5Comparison of receiver operating characteristic (ROC) curves of the univariate models of tibial maltorsion as a function of radiographic cortical and diameter parameters
Fig. 6Receiver operating characteristic (ROC) curves of the models of tibial maltorsion as a function of the combination of variables in the anterior posterior or lateral views demonstrating improved sensitivity and specificity