| Literature DB >> 34173107 |
A V Aleshkin1, L I Novikova1, S S Bochkareva1, S Yu Kombarova1, Yu S Lebedin2, A M Vorob'ev3, E R Mekhtiev1, E R Zul'karneev4, A I Laishevtsev4, A V Karaulov1.
Abstract
The presence of IgG and IgM antibodies in the venous blood of 76 patients with confirmed COVID-19 infection was determined by ELISA using Russian test systems. Different levels of IgM antibodies to N-protein and receptor binding domain of the Spike protein (RBD) were revealed. The dynamics of IgG antibodies to the whole virion antigen and recombinant antigens showed high values on weeks 4-5 of the disease. The level of IgG antibodies to Nprotein remained low throughout the observation period. The characteristic dynamics of IgG measured using test systems with sorbed whole virion or recombinant spike proteins reflects the duration of the disease.Entities:
Keywords: COVID-19; SARS-CoV-2; antibodies; dynamics; humoral immunity
Year: 2021 PMID： 34173107 PMCID： PMC8233179 DOI： 10.1007/s10517-021-05200-9
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804