Adrian I Campos1, Paul M Thompson2, Dick J Veltman3, Elena Pozzi4, Laura S van Veltzen4, Neda Jahanshad2, Mark J Adams5, Bernhard T Baune6, Klaus Berger7, Katharina Brosch8, Robin Bülow9, Colm G Connolly10, Udo Dannlowski11, Christopher G Davey12, Greig I de Zubicaray13, Danai Dima14, Tracy Erwin-Grabner15, Jennifer W Evans16, Cynthia H Y Fu17, Ian H Gotlib18, Roberto Goya-Maldonado15, Hans J Grabe19, Dominik Grotegerd11, Matthew A Harris5, Ben J Harrison12, Sean N Hatton20, Marco Hermesdorf7, Ian B Hickie20, Tiffany C Ho21, Tilo Kircher8, Axel Krug22, Jim Lagopoulos23, Hannah Lemke11, Katie McMahon24, Frank P MacMaster25, Nicholas G Martin26, Andrew M McIntosh5, Sarah E Medland27, Susanne Meinert11, Tina Meller8, Igor Nenadic8, Nils Opel11, Ronny Redlich11, Liesbeth Reneman28, Jonathan Repple11, Matthew D Sacchet29, Simon Schmitt8, Anouk Schrantee28, Kang Sim30, Aditya Singh15, Frederike Stein8, Lachlan T Strike31, Nic J A van der Wee32, Steven J A van der Werff32, Henry Völzke33, Lena Waltemate11, Heather C Whalley5, Katharina Wittfeld19, Margaret J Wright34, Tony T Yang21, Carlos A Zarate16, Lianne Schmaal35, Miguel E Rentería36. 1. Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. 2. Imaging Genetics Center, Mark & Mary Stevens Neuroimaging & Informatics Institute, Keck School of Medicine, University of Southern California, California. 3. Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam, the Netherlands. 4. Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia; Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia. 5. Division of Psychiatry, University of Edinburgh, Edinburgh, United Kingdom. 6. Department of Psychiatry, The University of Melbourne, Melbourne, Victoria, Australia; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Victoria, Australia; Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany. 7. Institute of Epidemiology and Social Medicine, University of Münster, Münster, North Rhine-Westphalia, Germany. 8. Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany. 9. Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany. 10. Department of Biomedical Sciences, Florida State University, Tallahassee, Florida. 11. Department of Psychiatry, University of Münster, Münster, North Rhine-Westphalia, Germany. 12. Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Victoria, Australia. 13. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia. 14. Department of Psychology, School of Arts and Social Sciences, City, University of London, London, United Kingdom; Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. 15. Laboratory of Systems Neuroscience and Imaging in Psychiatry, Department of Psychiatry and Psychotherapy, University Medical Center, Göttingen, Lower Saxony, Germany. 16. Experimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland. 17. Centre for Affective Disorders, Institute of Psychology, Psychiatry and Neuroscience, King's College London, London, United Kingdom; School of Psychology, University of East London, London, United Kingdom. 18. Department of Psychology, Stanford University, Stanford, California. 19. German Center for Neurodegenerative Disease, Greifswald, Mecklenburg-Vorpommern, Germany. 20. Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. 21. Department of Psychiatry & Weill Institute for Neurosciences, University of California San Francisco, San Francisco, California. 22. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, North Rhine-Westphalia, Germany; Department of Psychiatry, Philipps-University Marburg, Marburg, Hesse, Germany. 23. Thompson Institute, University of the Sunshine Coast, Sunshine Coast, Queensland, Australia; Brain and Mind Centre, University of Sydney, Sydney, New South Wales, Australia. 24. Herston Imaging Research Facility & School of Clinical Sciences, Queensland University of Technology, Brisbane, Queensland, Australia. 25. Department of Pediatrics and Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Strategic Clinical Network for Addictions and Mental Health, Alberta Health Services, Calgary, Alberta, Canada. 26. Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. 27. Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Psychiatric Genetics Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Austalia; School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. 28. Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, location AMC, Amsterdam, the Netherlands. 29. Center for Depression, Anxiety, and Stress Research, McLean Hospital, Harvard Medical School, Belmont, Massachusetts. 30. West Region, Institute of Mental Health, Buangkok View, Singapore; Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 31. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia. 32. Department of Psychiatry, Leiden University Medical Center, Leiden, the Netherlands; Leiden Institute for Brain and Cognition, Leiden, the Netherlands. 33. Institute for Community Medicine, University Medicine Greifswald, Greifswald, Mecklenburg-Vorpommern, Germany. 34. Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, The University of Queensland, Brisbane, Queensland, Australia. 35. Orygen, The National Centre of Excellence in Youth Mental Health, Parkville, Australia. Electronic address: lianne.schmaal@unimelb.edu.au. 36. Genetic Epidemiology Lab, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: miguel.renteria@qimrberghofer.edu.au.
Abstract
BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects. RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe. CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
BACKGROUND: Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior. METHODS: Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes between suicide attempters, clinical control subjects (nonattempters with depression), and healthy control subjects. RESULTS: We identified 25 regions of interest with statistically significant (false discovery rate < .05) differences between groups. Post hoc examinations identified neuroimaging markers associated with suicide attempt including smaller volumes of the left and right thalamus and the right pallidum and lower surface area of the left inferior parietal lobe. CONCLUSIONS: This study addresses the lack of replicability and consistency in several previously published neuroimaging studies of suicide attempt and further demonstrates the need for well-powered samples and collaborative efforts. Our results highlight the potential involvement of the thalamus, a structure viewed historically as a passive gateway in the brain, and the pallidum, a region linked to reward response and positive affect. Future functional and connectivity studies of suicidal behaviors may focus on understanding how these regions relate to the neurobiological mechanisms of suicide attempt risk.
Authors: Alan Anticevic; Michael W Cole; Grega Repovs; John D Murray; Margaret S Brumbaugh; Anderson M Winkler; Aleksandar Savic; John H Krystal; Godfrey D Pearlson; David C Glahn Journal: Cereb Cortex Date: 2013-07-03 Impact factor: 5.357
Authors: Maurizio Pompili; Marco Innamorati; J John Mann; Maria A Oquendo; David Lester; Antonio Del Casale; Gianluca Serafini; Silvia Rigucci; Andrea Romano; Antonino Tamburello; Giovanni Manfredi; Eleonora De Pisa; Stefan Ehrlich; Giancarlo Giupponi; Mario Amore; Roberto Tatarelli; Paolo Girardi Journal: Prog Neuropsychopharmacol Biol Psychiatry Date: 2008-05-20 Impact factor: 5.067
Authors: L Schmaal; D J Veltman; T G M van Erp; P G Sämann; T Frodl; N Jahanshad; E Loehrer; H Tiemeier; A Hofman; W J Niessen; M W Vernooij; M A Ikram; K Wittfeld; H J Grabe; A Block; K Hegenscheid; H Völzke; D Hoehn; M Czisch; J Lagopoulos; S N Hatton; I B Hickie; R Goya-Maldonado; B Krämer; O Gruber; B Couvy-Duchesne; M E Rentería; L T Strike; N T Mills; G I de Zubicaray; K L McMahon; S E Medland; N G Martin; N A Gillespie; M J Wright; G B Hall; G M MacQueen; E M Frey; A Carballedo; L S van Velzen; M J van Tol; N J van der Wee; I M Veer; H Walter; K Schnell; E Schramm; C Normann; D Schoepf; C Konrad; B Zurowski; T Nickson; A M McIntosh; M Papmeyer; H C Whalley; J E Sussmann; B R Godlewska; P J Cowen; F H Fischer; M Rose; B W J H Penninx; P M Thompson; D P Hibar Journal: Mol Psychiatry Date: 2015-06-30 Impact factor: 15.992
Authors: Lloyd T Elliott; Kevin Sharp; Fidel Alfaro-Almagro; Sinan Shi; Karla L Miller; Gwenaëlle Douaud; Jonathan Marchini; Stephen M Smith Journal: Nature Date: 2018-10-10 Impact factor: 49.962
Authors: Laura S van Velzen; Maria R Dauvermann; Lejla Colic; Luca M Villa; Hannah S Savage; Yara J Toenders; Alyssa H Zhu; Joanna K Bright; Adrián I Campos; Lauren E Salminen; Sonia Ambrogi; Rosa Ayesa-Arriola; Nerisa Banaj; Zeynep Başgöze; Jochen Bauer; Karina Blair; Robert James Blair; Katharina Brosch; Yuqi Cheng; Romain Colle; Colm G Connolly; Emmanuelle Corruble; Baptiste Couvy-Duchesne; Benedicto Crespo-Facorro; Kathryn R Cullen; Udo Dannlowski; Christopher G Davey; Katharina Dohm; Janice M Fullerton; Ali Saffet Gonul; Ian H Gotlib; Dominik Grotegerd; Tim Hahn; Ben J Harrison; Mengxin He; Ian B Hickie; Tiffany C Ho; Frank Iorfino; Andreas Jansen; Fabrice Jollant; Tilo Kircher; Bonnie Klimes-Dougan; Melissa Klug; Elisabeth J Leehr; Elizabeth T C Lippard; Katie A McLaughlin; Susanne Meinert; Adam Bryant Miller; Philip B Mitchell; Benson Mwangi; Igor Nenadić; Amar Ojha; Bronwyn J Overs; Julia-Katharina Pfarr; Fabrizio Piras; Kai G Ringwald; Gloria Roberts; Georg Romer; Marsal Sanches; Margaret A Sheridan; Jair C Soares; Gianfranco Spalletta; Frederike Stein; Giana I Teresi; Diana Tordesillas-Gutiérrez; Aslihan Uyar-Demir; Nic J A van der Wee; Steven J van der Werff; Robert R J M Vermeiren; Alexandra Winter; Mon-Ju Wu; Tony T Yang; Paul M Thompson; Miguel E Rentería; Neda Jahanshad; Hilary P Blumberg; Anne-Laura van Harmelen; Lianne Schmaal Journal: Mol Psychiatry Date: 2022-09-07 Impact factor: 13.437
Authors: Eun-Jin Cheon; Carrie E Bearden; Daqiang Sun; Christopher R K Ching; Ole A Andreassen; Lianne Schmaal; Dick J Veltman; Sophia I Thomopoulos; Peter Kochunov; Neda Jahanshad; Paul M Thompson; Jessica A Turner; Theo G M van Erp Journal: Psychiatry Clin Neurosci Date: 2022-02-26 Impact factor: 12.145
Authors: Anthony J Gifuni; M Mallar Chakravarty; Martin Lepage; Tiffany C Ho; Marie-Claude Geoffroy; Eric Lacourse; Ian H Gotlib; Gustavo Turecki; Johanne Renaud; Fabrice Jollant Journal: J Psychiatry Neurosci Date: 2021-05-07 Impact factor: 6.186