| Literature DB >> 36071108 |
Laura S van Velzen1,2, Maria R Dauvermann3,4,5, Lejla Colic6,7,8, Luca M Villa6,9, Hannah S Savage10,11, Yara J Toenders12,10, Alyssa H Zhu13, Joanna K Bright13,14, Adrián I Campos15,16,17, Lauren E Salminen13, Sonia Ambrogi18, Rosa Ayesa-Arriola19,20, Nerisa Banaj18, Zeynep Başgöze21, Jochen Bauer22, Karina Blair23, Robert James Blair23, Katharina Brosch24,25, Yuqi Cheng26,27, Romain Colle28,29, Colm G Connolly30, Emmanuelle Corruble28,29, Baptiste Couvy-Duchesne17,31, Benedicto Crespo-Facorro20,32, Kathryn R Cullen21, Udo Dannlowski33, Christopher G Davey34, Katharina Dohm33, Janice M Fullerton35,36, Ali Saffet Gonul37, Ian H Gotlib38, Dominik Grotegerd33, Tim Hahn33, Ben J Harrison11, Mengxin He26, Ian B Hickie39, Tiffany C Ho40,41, Frank Iorfino39, Andreas Jansen24,25,42, Fabrice Jollant7,28,43,44,45, Tilo Kircher24,25, Bonnie Klimes-Dougan46, Melissa Klug33, Elisabeth J Leehr33, Elizabeth T C Lippard47,48,49,50, Katie A McLaughlin51, Susanne Meinert33,52, Adam Bryant Miller53,54, Philip B Mitchell55, Benson Mwangi56,57, Igor Nenadić24,25, Amar Ojha58,59, Bronwyn J Overs35, Julia-Katharina Pfarr24,25, Fabrizio Piras18, Kai G Ringwald24,25, Gloria Roberts55, Georg Romer60, Marsal Sanches56,57, Margaret A Sheridan54, Jair C Soares56,57, Gianfranco Spalletta18,61, Frederike Stein24,25, Giana I Teresi38,62, Diana Tordesillas-Gutiérrez63,64, Aslihan Uyar-Demir37, Nic J A van der Wee65,66, Steven J van der Werff65,66,67, Robert R J M Vermeiren68,69, Alexandra Winter33, Mon-Ju Wu56,57, Tony T Yang70, Paul M Thompson13, Miguel E Rentería15,16, Neda Jahanshad13, Hilary P Blumberg6,71,72, Anne-Laura van Harmelen3,66,73, Lianne Schmaal12,10.
Abstract
Identifying brain alterations associated with suicidal thoughts and behaviors (STBs) in young people is critical to understanding their development and improving early intervention and prevention. The ENIGMA Suicidal Thoughts and Behaviours (ENIGMA-STB) consortium analyzed neuroimaging data harmonized across sites to examine brain morphology associated with STBs in youth. We performed analyses in three separate stages, in samples ranging from most to least homogeneous in terms of suicide assessment instrument and mental disorder. First, in a sample of 577 young people with mood disorders, in which STBs were assessed with the Columbia Suicide Severity Rating Scale (C-SSRS). Second, in a sample of young people with mood disorders, in which STB were assessed using different instruments, MRI metrics were compared among healthy controls without STBs (HC; N = 519), clinical controls with a mood disorder but without STBs (CC; N = 246) and young people with current suicidal ideation (N = 223). In separate analyses, MRI metrics were compared among HCs (N = 253), CCs (N = 217), and suicide attempters (N = 64). Third, in a larger transdiagnostic sample with various assessment instruments (HC = 606; CC = 419; Ideation = 289; HC = 253; CC = 432; Attempt=91). In the homogeneous C-SSRS sample, surface area of the frontal pole was lower in young people with mood disorders and a history of actual suicide attempts (N = 163) than those without a lifetime suicide attempt (N = 323; FDR-p = 0.035, Cohen's d = 0.34). No associations with suicidal ideation were found. When examining more heterogeneous samples, we did not observe significant associations. Lower frontal pole surface area may represent a vulnerability for a (non-interrupted and non-aborted) suicide attempt; however, more research is needed to understand the nature of its relationship to suicide risk.Entities:
Year: 2022 PMID： 36071108 DOI： 10.1038/s41380-022-01734-0
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 13.437