Literature DB >> 3416918

5-HT2 receptor agonists increase spontaneous sympathetic nerve discharge.

R B McCall1, L T Harris.   

Abstract

The selective 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) produced a marked increase in spontaneous sympathetic nerve discharge recorded from the inferior cardiac nerve in chloralose anesthetized cats. DOI (0.01-1.0 mg/kg i.v.) increased sympathetic nerve discharge to a maximum of 1750% of control values. The increase in sympathetic nerve discharge produced by DOI was reversed by the 5-HT2 antagonists ketanserin and LY 53857. In addition, pretreatment with ketanserin, but not prazosin, completely prevented the increase in sympathetic nerve discharge produced by DOI. These data are discussed in relationship to the role of serotonin in the regulation of activity in central sympathetic pathways.

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Year:  1988        PMID： 3416918     DOI： 10.1016/0014-2999(88)90698-x

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  9 in total

1.  Investigation of the effects of IVth ventricular administration of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), on autonomic outflow in the anaesthetized cat.

Authors:  S L Shepheard; D Jordan; A G Ramage
Journal:  Br J Pharmacol       Date:  1991-10       Impact factor: 8.739

2.  Enhancement of [m-methoxy 3H]MDL100907 binding to 5HT2A receptors in cerebral cortex and brain stem of streptozotocin induced diabetic rats.

Authors:  J Jackson; C S Paulose
Journal:  Mol Cell Biochem       Date:  1999-09       Impact factor: 3.396

3.  Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats.

Authors:  Valiya Veettil Mohanan; Finla Chathu; Cheramadathikudyil S Paulose
Journal:  Mol Cell Biochem       Date:  2005-04       Impact factor: 3.396

4.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

5.  5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells.

Authors:  L D Van de Kar; A Javed; Y Zhang; F Serres; D K Raap; T S Gray
Journal:  J Neurosci       Date:  2001-05-15       Impact factor: 6.167

6.  Evidence that activation of 5-HT2 receptors in the forebrain of anaesthetized cats causes sympathoexcitation.

Authors:  I K Anderson; G R Martin; A G Ramage
Journal:  Br J Pharmacol       Date:  1995-09       Impact factor: 8.739

7.  Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/5-HT1C receptors to release vasopressin in anaesthetized rats.

Authors:  I K Anderson; G R Martin; A G Ramage
Journal:  Br J Pharmacol       Date:  1992-12       Impact factor: 8.739

8.  Examination of the effects of some 5-HT2 receptor antagonists on central sympathetic outflow and blood pressure in anaesthetised cats.

Authors:  A G Ramage
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1988-12       Impact factor: 3.000

9.  The serotonin 2A receptor agonist 25CN-NBOH increases murine heart rate and neck-arterial blood flow in a temperature-dependent manner.

Authors:  Tobias Buchborn; Taylor Lyons; Chenchen Song; Amanda Feilding; Thomas Knöpfel
Journal:  J Psychopharmacol       Date:  2020-02-12       Impact factor: 4.153
  9 in total

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