Literature DB >> 16010984

Decreased 5-HT2C receptor binding in the cerebral cortex and brain stem during pancreatic regeneration in rats.

Valiya Veettil Mohanan1, Finla Chathu, Cheramadathikudyil S Paulose.   

Abstract

The purpose of this study was to investigate the role of central 5-HT2C receptor binding in rat model of pancreatic regeneration using 60-70% pancreatectomy. The 5-HT and 5-HT2C receptor kinetics were studied in cerebral cortex and brain stem of sham operated, 72 h pancreatectomised and 7 days pancreatectomised rats. Scatchard analysis with [3H] mesulergine in cerebral cortex showed a significant decrease (p < 0.05) in maximal binding (Bmax) without any change in Kd in 72 h pancreatectomised rats compared with sham. The decreased Bmax reversed to sham level by 7 days after pancreatectomy. In brain stem, Scatchard analysis showed a significant decrease (p < 0.01) in Bmax with a significant increase (p < 0.01) in Kd. Competition analysis in brain stem showed a shift in affinity towards a low affinity. These parameters were reversed to sham level by 7 days after pancreatectomy. Thus the results suggest that 5-HT through the 5-HT2C receptor in the brain has a functional regulatory role in the pancreatic regeneration.

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Year:  2005        PMID： 16010984     DOI： 10.1007/s11010-005-7030-0

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  29 in total

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Authors:  Valiya veettil Mohanan; S Balarama Kaimal; Cheramadathikudyil S Paulose
Journal:  Neurochem Res       Date:  2005-01       Impact factor: 3.996

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  3 in total

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  3 in total

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