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Literature DB >> 34165344

Interspecies chimeras as a platform for exogenic organ production and transplantation.

Daniel J Garry^1,2,3,4, Mary G Garry^1,2,3,4.

Abstract

Chronic diseases are associated with considerable morbidity and mortality. Therefore, new therapeutic strategies are warranted. Here, we provide a brief review outlining the rationale and feasibility for the generation of intraspecies and interspecies chimeras, which one day may serve as a platform for organ transplantation. These strategies are further associated with consideration of scientific and ethical issues.

Entities: Chemical

Keywords: Chimera; ETV2; MYF5; MYF6; MYOD; hiPSCs; somatic cell nuclear transfer

Mesh：

Year: 2021 PMID： 34165344 PMCID： PMC8381704 DOI： 10.1177/15353702211024948

Source DB: PubMed Journal: Exp Biol Med (Maywood) ISSN： 1535-3699

52 in total

1. Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

Authors: H Wang; P Maechler; B Ritz-Laser; K A Hagenfeldt; H Ishihara; J Philippe; C B Wollheim
Journal: J Biol Chem Date: 2001-04-17 Impact factor: 5.157

Review 2. Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.

Authors: Trevor L Davis; Ilaria Rebay
Journal: Dev Biol Date: 2016-12-13 Impact factor: 3.582

3. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.

Authors: Toshihiro Kobayashi; Tomoyuki Yamaguchi; Sanae Hamanaka; Megumi Kato-Itoh; Yuji Yamazaki; Makoto Ibata; Hideyuki Sato; Youn-Su Lee; Jo-Ichi Usui; A S Knisely; Masumi Hirabayashi; Hiromitsu Nakauchi
Journal: Cell Date: 2010-09-03 Impact factor: 41.582

4. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.

Authors: Xiaozhong Shi; Jai Richard; Katie M Zirbes; Wuming Gong; Gufa Lin; Michael Kyba; Jamie A Thomson; Naoko Koyano-Nakagawa; Daniel J Garry
Journal: Dev Biol Date: 2014-02-26 Impact factor: 3.582

5. Generation of human endothelium in pig embryos deficient in ETV2.

Authors: Satyabrata Das; Naoko Koyano-Nakagawa; Ohad Gafni; Geunho Maeng; Bhairab N Singh; Tara Rasmussen; Xiaoyan Pan; Kyung-Dal Choi; Daniel Mickelson; Wuming Gong; Pruthvi Pota; Cyprian V Weaver; Stefan Kren; Jacob H Hanna; Demetris Yannopoulos; Mary G Garry; Daniel J Garry
Journal: Nat Biotechnol Date: 2020-02-24 Impact factor: 54.908

6. The Etv2-miR-130a Network Regulates Mesodermal Specification.

Authors: Bhairab N Singh; Yasuhiko Kawakami; Ryutaro Akiyama; Tara L Rasmussen; Mary G Garry; Wuming Gong; Satyabrata Das; Xiaozhong Shi; Naoko Koyano-Nakagawa; Daniel J Garry
Journal: Cell Rep Date: 2015-10-22 Impact factor: 9.423

7. Interspecies organogenesis generates autologous functional islets.

Authors: Tomoyuki Yamaguchi; Hideyuki Sato; Megumi Kato-Itoh; Teppei Goto; Hiromasa Hara; Makoto Sanbo; Naoaki Mizuno; Toshihiro Kobayashi; Ayaka Yanagida; Ayumi Umino; Yasunori Ota; Sanae Hamanaka; Hideki Masaki; Sheikh Tamir Rashid; Masumi Hirabayashi; Hiromitsu Nakauchi
Journal: Nature Date: 2017-01-25 Impact factor: 49.962

Interspecies chimeras as a platform for exogenic organ production and transplantation.

1. Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation.

Review 2. Master regulators in development: Views from the Drosophila retinal determination and mammalian pluripotency gene networks.

3. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells.

4. Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages.

5. Generation of human endothelium in pig embryos deficient in ETV2.

6. The Etv2-miR-130a Network Regulates Mesodermal Specification.

7. Interspecies organogenesis generates autologous functional islets.

8. Divergent and convergent evolution of housekeeping genes in human-pig lineage.

9. Etv2-miR-130a-Jarid2 cascade regulates vascular patterning during embryogenesis.

Review 10. Xenotransplantation: Current Status in Preclinical Research.

1. Introduction to the Regenerative Medicine Thematic Issue.