Safety and feasibility of uniportal video-assisted thoracoscopic uncommon segmentectomy.

BACKGROUND: In recent years, opportunities to conduct anatomical segmentectomies for early stage lung cancer, metastatic lung tumor, and so on have been increasing. Generally, uniportal video-assisted thoracoscopic surgery (U-VATS) uncommon segmentectomy is technically more complicated because of limited angulation compared to multiportal VATS (M-VATS) and the need to treat peripheral vessels/bronchi compared to common segmentectomy. This study aimed to determine the safety and feasibility of U-VATS uncommon segmentectomy compared with U-VATS common segmentectomy and M-VATS uncommon segmentectomy.
METHODS: We retrospectively reviewed the medical records of 76 patients in the M-VATS group and 45 patients in the U-VATS group who underwent VATS segmentectomy from January 2015 to December 2020. During that period, the perioperative results of U-VATS uncommon (n=22) segmentectomy were compared with those of U-VATS common (n=23) and M-VATS uncommon (n=37) segmentectomy. Uncommon segmentectomy was defined as any segmentectomy other than segmentectomies of the lingual, basilar, or superior segment of the lower lobe (S6), and upper division of the left upper lobe. All patients in our department underwent preoperative three-dimensional computed tomography (3D-CT) angiography and bronchography to image bronchovascular structures and determine the resection line.
RESULTS: Patients characteristics were similar between the U-VATS uncommon segmentectomy group and the U-VATS common segmentectomy group or the M-VATS uncommon segmentectomy group. In U-VATS, there were no significant differences between common and uncommon segmentectomy in operation time, postoperative drainage, postoperative hospitalization, and postoperative complications. Comparing M-VATS and U-VATS uncommon segmentectomies, operation time (145±35 vs. 185±44 min, P<0.001) and postoperative hospitalization (3.1±1.6 vs. 4.2±1.8 days, P=0.02) were significantly shorter in the U-VATS group than in the M-VATS group. There were no significant differences in blood loss, intraoperative bleeding, duration of postoperative drainage and postoperative complications.
CONCLUSIONS: In U-VATS, both types of segmentectomies can be achieved with similar results. Moreover, U-VATS shortened operation time and postoperative hospitalization in uncommon segmentectomy compared with conventional M-VATS. U-VATS is a useful approach for uncommon segmentectomy. 2021 Journal of Thoracic Disease. All rights reserved.

Introduction

In recent years, opportunities for lung segmentectomy for early-stage lung cancer with ground glass opacities and small nodules have been increasing (1). Segmentectomy is also an effective surgical procedure for frail cases that cannot tolerate radical surgery for primary lung cancer and cases with metastatic tumors near the hilum. Segmentectomy is usually categorized into common (simple) and uncommon (complex) segmentectomy, and uncommon segmentectomy is technically more complicated because blood vessels and bronchi need to be identified to the periphery and dissected, and there are multiple intersegmental planes to be separated.

Rocco first reported Uniportal video-assisted thoracoscopic surgery (U-VATS) for wedge resection in 2004 (2). Gonzalez-Rivas first reported single-incision VATS lobectomy in 2012 (3,4), and afterwards reported U-VATS segmentectomy (5). The potential benefits of U-VATS reported so far are wound pain reduction, neuralgia reduction, and cosmetic aspects (6-10). However, U-VATS has some difficulties compared with multiportal VATS (M-VATS) because the angle of the forceps is limited, and the stapler is inserted in only one direction. Therefore, there are concerns that uncommon segmentectomy by U-VATS will have some technical problems and increase the risk.

This study aimed to identify the safety and feasibility of U-VATS uncommon segmentectomy compared with U-VATS common segmentectomy and M-VATS uncommon segmentectomy.

We present the following article in accordance with the STROBE reporting checklist (available at http://dx.doi.org/10.21037/jtd-21-292).

Methods

Patient selection

The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the institutional ethics board of Maebashi Red Cross Hospital (NO.: 2020-52), and individual patient consent for this retrospective analysis was waived.

We retrospectively reviewed the medical records of patients who underwent VATS segmentectomy from January 2015 to December 2020. Of them, 45 patients underwent U-VATS and 75 patients underwent M-VATS, and each was classified into common or uncommon segmentectomy (). Uncommon segmentectomy was defined as any segmentectomy other than segmentectomies of the lingual, basilar, or superior segment of the lower lobe (S6), and the upper division of the left upper lobe (11).

Figure 1

Flow diagram of patient selection. M-VATS, multiportal VATS; U-VATS, uniportal VATS.

All patients in our department, except for cases with contrast agent allergy, underwent preoperative three-dimensional computed tomography (3D-CT) angiography and bronchography to image bronchovascular structures and tumor location and determine the resection line.

In our department, the standard curative surgery for primary lung cancer is lobectomy with systemic lymph node dissection. In patients who underwent intentional segmentectomy for primary lung cancer, clinical stage 0-IA1 (Tis-1aN0M0) was confirmed by careful preoperative staging with CT and/or FDG-PET. For patients who could not tolerate radical surgery due to complications and poor pulmonary function, segmentectomy was also performed as reduction surgery. In patients with metastatic lung tumors, segmentectomy was performed only when it was difficult to secure enough margin in wedge resection due to the location and size of tumor.

Postoperative complications were evaluated with the Common Terminology Criteria for Adverse Events version 5.0. The major complications were defined as requiring additional treatment.

M-VATS was performed by three senior surgeons, and U-VATS was performed by two of them. U-VATS was started in February 2019 and the surgical procedure was decided by the surgeon.

The study was approved by the institutional ethics board of Maebashi Red Cross Hospital (NO.:2020-52), and individual patient consent for this retrospective analysis was waived.

Procedure for U-VATS

Surgery was carried out under general anesthesia in all cases, with the patient in the lateral decubitus position under differential lung ventilation. The operator always stood on the ventral side and the assistant on the dorsal side of the patient. A 3.5–4.0-cm skin incision was made in the fourth intercostal anterior axillary line for right upper lobectomy or the fifth intercostal anterior axillary line for other types of surgery and an XS Alexis wound retractor (Applied Medical, Rancho Santa Margarita, CA, USA) was fitted. Either a 5-mm or 10-mm 30º degree thoracoscope was immobilized on the dorsal side of the wound margin, with the ventral side providing space for the operator to manipulate the scope. Vessel and bronchial transection were in principle carried out with an automated suturing device, but suture ligation with 3-0 silk was performed if required by the vessel diameter. The inflation-deflation technique was normally used for segment identification. From May 2020, indocyanine green (ICG) was administered intravenously and an infrared thoracoscope was also used for observations. In almost all cases, intersegmental division was accomplished using only an automated suturing device, but for some patients a cautery was used where necessary. The chest drain was placed from the ventral side of the wound. As an example, detailed procedures for right apical segmentectomy (S1) are shown in .

Figure 2

Detailed procedures for right apical segmentectomy (S1) by uniportal VATS. (A) After dissection of the mediastinal pleura and fat tissue, the superior trunk of the pulmonary artery is exposed; (B) Apical artery (A1) divided by stapler; (C) Apical segmental vein (V1a+b); (D) Apical segmental bronchus (B1) divided by stapler; (E) Marking the intersegmental plane using inflation-deflation technique; (F) Completion of apical segmentectomy (S1) creating the intersegmental plane by a stapler. VATS, video-assisted thoracoscopic surgery.

Procedure for M-VATS

Three or four ports were used, and XXS Alexis wound retractors were fitted to a 2.0-cm skin incision on the fourth intercostal anterior axillary line and a 1.5-cm skin incision on the sixth intercostal anterior axillary line. A 10-mm flexible camera was inserted via the 1.5-cm skin incision on the sixth intercostal anterior axillary line. When four ports were used, an additional 15-mm skin incision was made in the seventh intercostal space below the scapula for use as the assistant’s port. Segmentectomy was performed in the same way as in U-VATS. The chest drain was placed via the port on the sixth intercostal anterior axillary line.

Statistical analysis

Fisher’s exact test was applied for comparing categorical variables. The t-test was applied for comparing continuous variables. A P<0.05 was considered statistically significant. All statistical analyses were performed with EZR (Saitama Medical Center, Jichi Medical University, Saitama, Japan), which is a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria).

Results

Patient characteristics and segmentectomy performed by U-VATS and M-VATS

The characteristics of all patients are shown in . There were 87 (72.5%) cases of primary lung cancer, 50 (57.5%) of which underwent intentional segmentectomy. The details of segmentectomies performed by U-VATS and M-VATS are shown in . In the U-VATS group, there were no uncommon segmentectomies of the left lower lobe.

Table 1

Characteristics of all patients. Data are shown as mean ± standard deviation or number (%)

Characteristic	n=120 (%)
Age	70±11.4
Sex, male	65 (54.2)
Location of tumor
Right upper lobe	26 (21.7)
Right lower lobe	33 (27.5)
Left upper lobe	43 (35.8)
Left lower lobe	18 (15)
Disease
Primary lung cancer	87 (72.5)
Intentional	50 (57.5)
Unintentional	37 (42.5)
Inflammatory	20 (16.7)
Metastatic tumor	13 (10.8)
Surgical approach
U-VATS	45 (37.5)
M-VATS	75 (62.5)

U-VATS, uniportal video-assisted thoracoscopic surgery; M-VATS, multiportal video-assisted thoracoscopic surgery.

Table 2

Segmentectomy performed by U-VATS. Data are shown as number (%)

	Uncommon segmentectomy	n=22 (%)	Common segmentectomy	n=23 (%)
Right side		15 (68.2)		10 (43.4)
Upper lobe		10 (45.4)		0 (0)
	S1	2 (9.1)
	S2	3 (13.6)
	S3	2 (9.1)
	S1+3	3 (13.6)
Lower lobe		5 (22.7)		10 (43.4)
	S7+8+9	1 (4.6)	S6	5 (21.7)
	S9+10	4 (18.1)	Basal segment	5 (21.7)
Left side		7 (31.8)		13 (56.6)
Upper lobe		7 (31.8)		9 (39.2)
	S1+2	3 (13.6)	Upper divisional segment	7 (30.5)
	S3	3 (13.6)	Lingual segment	2 (8.7)
	S3+4+5	1 (4.6)
Lower lobe		0		4 (17.4)
			S6	3 (13)
			Basal segment	1 (4.4)

U-VATS, uniportal video-assisted thoracoscopic surgery.

Table 3

Segmentectomy performed by M-VATS. Data are shown as number (%).

	Uncommon segmentectomy	n=37 (%)	Common segmentectomy	n=38 (%)
Right side		23 (62.2)		13 (34.2)
Upper lobe		15 (40.6)		0 (0)
	S1	1 (2.7)
	S2	3 (8.1)
	S3	6 (16.2)
	S1+2	1 (2.7)
	Others including the subsegment	4 (10.9)
Lower lobe		8 (21.6)		13 (34.2)
	S7+8	2 (5.4)	S6	11 (28.9)
	S8+9	1 (2.7)	Basal segment	2 (5.3)
	S9+10	5 (13.5)
Left side		14 (37.8)		25 (65.8)
Upper lobe		12 (32.4)		16 (42.1)
	S1+2	6 (16.2)	Upper divisional segment	11 (28.9)
	S3	3 (8.1)	Lingual segment	5 (13.2)
	S3+4+5	2 (5.4)
	Others including the subsegment	1 (2.7)
Lower lobe		2 (5.4)		9 (23.7)
	S8+9	1 (2.7)	S6	7 (18.4)
	S9+10	1 (2.7)	Basal segment	2 (5.3)

M-VATS, multiportal video-assisted thoracoscopic surgery.

Comparison between common and uncommon segmentectomies in U-VATS

Comparison of patient characteristics and perioperative outcomes between the common and uncommon segmentectomy groups in U-VATS are shown in . There were no significant differences between the groups in patient characteristics including age, sex, and disease. No significant intraoperative bleeding (bleeding from the pulmonary artery or vein that could be managed under VATS) and no conversions to thoracotomy were observed in the uncommon segmentectomy group, and the mean intraoperative blood loss was significantly less in the uncommon segmentectomy group than in the common segmentectomy group (70±115 mL in common vs. 15±26 mL in uncommon, P=0.034). There were no significant differences in the duration of postoperative drainage and the duration of postoperative hospitalization.

Table 4

Comparison of patient characteristics and perioperative outcomes between common and uncommon segmentectomies in U-VATS, and between the M-VATS and U-VATS uncommon segmentectomies. Data are shown as mean ± standard deviation or number (%)

	U-VATS Uncommon (n=23)	U-VATS Common (n=22)	P	M-VATS Uncommon (n=37)	P
Age, yr	70.5±10.8	70.2±9.8	0.928	70.5±13.1	0.999
Sex, male	13 (59.1)	11 (47.3)	0.382	21 (56.8)	1.000
Disease			1.000		0.120
Primary lung cancer	17 (77.3)	16 (70.0)		28 (75.7)
Metastatic tumor	1 (4.5)	2 (8.7)		7 (18.9)
Inflammatory	4 (18.2)	5 (21.3)		2 (5.4)
Tumor location			0.036		0.888
Right	16 (72.7)	9 (39.1)		23 (62.2)
Operation time, min	145±35	136±58	0.535	185±44	<0.001
Blood loss, mL	15±26	70±115	0.034	35±49	0.084
Intraoperative bleeding	0 (0)	4 (17.4)	0.109	2 (5.4)	0.524
Conversion to thoracotomy	0 (0)	2 (8.7)	0.489	2 (5.4)	0.524
Postoperative drainage, days	1.7±1.5	1.4±0.9	0.495	2.1±1.3	0.216
Postoperative hospitalization, days	3.1±1.6	3.5±1.6	0.482	4.2±1.8	0.020
Postoperative complications	3 (13.6)	1 (4.3)	0.346	4 (10.8)	1.000

M-VATS, multiportal video-assisted thoracoscopic surgery; U-VATS, uniportal video-assisted thoracoscopic surgery.

Postoperative complications occurred in 1 patient (4.3%) in the common segmentectomy group: who had atrial fibrillation. On the other hand, in the uncommon segmentectomy group, 3 patients (13.6%) had postoperative complications: prolonged air leak in 1, delayed pneumothorax in 1 and hypoxemia in 1. There was no significant difference in the rate of postoperative complications between the groups (P=0.346).

Comparison between M-VATS and U-VATS uncommon segmentectomies

Comparisons of patient characteristics and perioperative outcomes between the M-VATS and U-VATS uncommon segmentectomies are shown in . There were no significant differences between the groups in patient characteristics including age, sex, disease and tumor location. Operation time was significantly shorter in the U-VATS group than in the M-VATS group (145±35 vs. 185±44 min, P<0.001). There were no significant differences in blood loss, intraoperative bleeding and duration of postoperative drainage. The duration of postoperative hospitalization was significantly shorter in the U-VATS group than in the M-VATS group (3.1±1.6 vs. 4.2±1.8 days, P=0.02).

Four patients (10.8%) in the M-VATS group had postoperative complications, including prolonged air leak in 1, delayed pneumothorax in 2 and hypoxemia in 1. There was no significant difference in the rate of postoperative complications between the groups (P=1.000).

Discussion

This study showed that the perioperative results of U-VATS uncommon segmentectomy are equivalent to those of U-VATS common segmentectomy or M-VATS uncommon segmentectomy and can be performed safely.

Although the standard radical surgery for primary lung cancer is still lobectomy (12), ground glass opacity (GGO) on thin-section CT has been shown to have a very good prognosis, and sublobar resection has become widespread (13). For metastatic lung tumors and inflammatory disease, sublobar resection is also performed. Segmentectomy can be performed even for lesions that are not present on the periphery of the lung and cannot be palpated, while ensuring sufficient margin, combined with preoperative 3D-CT simulation. However, uncommon segmentectomy is technically challenging in terms of treating fragile vessels and peripheral bronchi and creating several intersegmental planes. Handa et al. evaluated operative and postoperative outcomes of complex and simple segmentectomies and showed that only median operative time (180 vs. 143.5 min, P<0.0001) was significantly longer in the complex group (11). Xie et al. also reported that in both U-VATS (P<0.001) and M-VATS (P=0.011), operation time was significantly longer in the complex segmentectomy group than in the simple segmentectomy group (14). Moreover, in a randomized controlled trial to confirm the noninferiority of segmentectomy to lobectomy (JCOG0802/WJOG4607L), complex segmentectomy was a predictor of air leak and empyema (grade ≥2) (odds ratio, 2.07; 95% CI, 1.11–3.88; P=0.023) (15). This may be due to the procedure of creating a fissure, which included cautery, stapler and cautery, or stapler. We mainly use a stapler to create an intersegmental plane, and we previously reported no significant differences in perioperative results including blood loss, operation time, drainage, hospitalization and morbidity between common and uncommon segmentectomy group (16).

Several papers comparing the results of segmentectomy by M-VATS and U-VATS have been reported, all of which were comparable (14,17,18). A technical difficulty with U-VATS is that the angle of the forceps and stapler insertion is limited. In U-VATS, the camera is basically fixed to the dorsal side of the wound edge to secure the operator’s space on the ventral side, and a curved long suction tube is used to avoid interference of the forceps. By arranging them in the optimal position inside and outside the thoracic cavity, smooth operation is possible. Ligation with 3-0 silk is also useful for vessel dissection when a stapler is not adequate in segmentectomy. Before creating the intersegmental plane, the distal bronchial and vessel stumps are fully dissected from the surrounding tissue to the periphery, creating the space for stapler insertion. When inserting the stapler, it is important to move the lungs significantly to match the stapler insertion angle.

Cheng et al. reported about the learning curve for U-VATS segmentectomy, showing that an experienced surgeon can achieve a relatively stable level after 33 cases (19). In the present study, operation time was significantly shorter in the U-VATS uncommon segmentectomy group than in the M-VATS uncommon segmentectomy group. Possible reasons include the following. Firstly, U-VATS was started in 2019, and there may have been an effect due to differences in experience and skill when operators who had previously mastered segmentectomy by performing it numerous times in M-VATS shifted to U-VATS. Secondly, in U-VATS the camera is inserted from the same angle as the operator, meaning that its field of view is consistent with the operator’s viewpoint, and this gives the operator a sense similar to conducting open-chest surgery. Finally, the use of forceps and energy devices designed and developed for U-VATS enabled the operator to carry out dissection effectively and rapidly.

This study has several weaknesses because of its retrospective design. The total number of cases is relatively small, so a prospective and multicenter study is required. In addition, the study period was too short to evaluate long-term outcomes. In particular, it is necessary to examine the long-term oncologic results of cases of primary lung cancer.

In conclusion, common and uncommon segmentectomies can be achieved in U-VATS with similar results. In the present study, similar perioperative results such as blood loss and the postoperative complication rate could be observed between U-VATS and M-VATS. Moreover, U-VATS shortened the operation time and postoperative hospitalization in uncommon segmentectomy compared with M-VATS. U-VATS is a safe and useful approach to perform uncommon segmentectomy.

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