Literature DB >> 34159621

Prime time for the recycling endosome.

Brian P Ceresa1.   

Abstract

Receptor crosstalk is the phenomenon by which one cell surface receptor communicates with another to modulate its activity. In this issue, Smith et␣al (2021) demonstrate that such crosstalk may involve endocytic trafficking, as ligands promoting FGFR2b recycling induce a specific "priming" EGFR phosphorylation to direct unliganded EGFR to the recycling endosome, slow the lysosomal degradation of ligand-stimulated EGFR, and enhance signaling and cell proliferation.
© 2021 The Authors.

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Year:  2021        PMID： 34159621      PMCID： PMC8447598          DOI： 10.15252/embj.2021108758

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   14.012


  5 in total

1.  Somatic mutations lead to an oncogenic deletion of met in lung cancer.

Authors:  Monica Kong-Beltran; Somasekar Seshagiri; Jiping Zha; Wenjing Zhu; Kaumudi Bhawe; Nerissa Mendoza; Thomas Holcomb; Kanan Pujara; Jeremy Stinson; Ling Fu; Christophe Severin; Linda Rangell; Ralph Schwall; Lukas Amler; Dineli Wickramasinghe; Robert Yauch
Journal:  Cancer Res       Date:  2006-01-01       Impact factor: 12.701

2.  Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor.

Authors:  G J Heisermann; H S Wiley; B J Walsh; H A Ingraham; C J Fiol; G N Gill
Journal:  J Biol Chem       Date:  1990-08-05       Impact factor: 5.157

3.  Prime time for the recycling endosome.

Authors:  Brian P Ceresa
Journal:  EMBO J       Date:  2021-06-23       Impact factor: 14.012

4.  Reciprocal priming between receptor tyrosine kinases at recycling endosomes orchestrates cellular signalling outputs.

Authors:  Michael P Smith; Harriet R Ferguson; Jennifer Ferguson; Egor Zindy; Katarzyna M Kowalczyk; Thomas Kedward; Christian Bates; Joseph Parsons; Joanne Watson; Sarah Chandler; Paul Fullwood; Stacey Warwood; David Knight; Robert B Clarke; Chiara Francavilla
Journal:  EMBO J       Date:  2021-06-04       Impact factor: 14.012

5.  Differential effects of EGFR ligands on endocytic sorting of the receptor.

Authors:  Kirstine Roepstorff; Michael Vibo Grandal; Lasse Henriksen; Stine Louise Jeppe Knudsen; Mads Lerdrup; Lene Grøvdal; Berthe Marie Willumsen; Bo van Deurs
Journal:  Traffic       Date:  2009-05-19       Impact factor: 6.215
  5 in total
  1 in total

1.  Prime time for the recycling endosome.

Authors:  Brian P Ceresa
Journal:  EMBO J       Date:  2021-06-23       Impact factor: 14.012
  1 in total

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