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Literature DB >> 34157264

Cytoskeletal biophysics: Passive crosslinker adapts to keep microtubule bundles on track.

Abstract

Assembly of the mitotic spindle requires dynamic adaptation and coordination among an array of motors and crosslinkers. A new study demonstrates in vitro how the mitotic crosslinker PRC1 can tune its behavior to regulate the speed of microtubule sliding.

Entities: Chemical

Mesh：

Year: 2021 PMID： 34157264 PMCID： PMC9364691 DOI： 10.1016/j.cub.2021.04.065

Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.900

Keyword Cloud
References

20 in total

1. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.

Authors: Yasuhiro Kurasawa; William C Earnshaw; Yuko Mochizuki; Naoshi Dohmae; Kazuo Todokoro
Journal: EMBO J Date: 2004-08-05 Impact factor: 11.598

2. Multiple modes of cytoplasmic dynein regulation.

Authors: Richard B Vallee; Richard J McKenney; Kassandra M Ori-McKenney
Journal: Nat Cell Biol Date: 2012-02-29 Impact factor: 28.824

Review 3. The Spindle: Integrating Architecture and Mechanics across Scales.

Authors: Mary Williard Elting; Pooja Suresh; Sophie Dumont
Journal: Trends Cell Biol Date: 2018-08-06 Impact factor: 20.808

4. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

Authors: Beate Neumann; Thomas Walter; Jean-Karim Hériché; Jutta Bulkescher; Holger Erfle; Christian Conrad; Phill Rogers; Ina Poser; Michael Held; Urban Liebel; Cihan Cetin; Frank Sieckmann; Gregoire Pau; Rolf Kabbe; Annelie Wünsche; Venkata Satagopam; Michael H A Schmitz; Catherine Chapuis; Daniel W Gerlich; Reinhard Schneider; Roland Eils; Wolfgang Huber; Jan-Michael Peters; Anthony A Hyman; Richard Durbin; Rainer Pepperkok; Jan Ellenberg
Journal: Nature Date: 2010-04-01 Impact factor: 49.962

Cytoskeletal biophysics: Passive crosslinker adapts to keep microtubule bundles on track.

1. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.

2. Multiple modes of cytoplasmic dynein regulation.

Review 3. The Spindle: Integrating Architecture and Mechanics across Scales.

4. Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes.

5. Diffusible crosslinkers generate directed forces in microtubule networks.

6. The evolution of animal cell motility.

7. Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.

Review 8. Architecture shapes contractility in actomyosin networks.

Review 9. Control of microtubule organization and dynamics: two ends in the limelight.

10. Two modes of PRC1-mediated mechanical resistance to kinesin-driven microtubule network disruption.