Rogério Jardim Caldas1,2, Héliton Spíndola Antunes3, Camila de Oliveira Rodini Pegoraro4, Fábio Ribeiro Guedes5, Paulo Sérgio da Silva Santos6. 1. Department of Dentistry, Mario Kroeff Hospital, Rio de Janeiro, Brazil. dr.rogeriocaldas@gmail.com. 2. Department of Surgery, Stomatology, Pathology and Radiology, University of Sao Paulo, Bauru School of Dentistry, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil. dr.rogeriocaldas@gmail.com. 3. Division of Clinical Research and Technological Development, National Institute of Cancer, Rio de Janeiro, Brazil. 4. Department of Biological Sciences, University of Sao Paulo, Bauru School of Dentistry, Bauru, Brazil. 5. Faculty of Dentistry, Department of Pathology and Oral Diagnosis, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. 6. Department of Surgery, Stomatology, Pathology and Radiology, University of Sao Paulo, Bauru School of Dentistry, Alameda Dr. Octávio Pinheiro Brisolla, 9-75, Bauru, São Paulo, 17012-901, Brazil.
Abstract
OBJECTIVES: To investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population. METHODS: A multicenter cross-sectional study was conducted with cancer patients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. RESULTS: The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). CONCLUSIONS: Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.
OBJECTIVES: To investigate the association of oral health condition with the occurrence of medication-related osteonecrosis of the jaw (MRONJ) in a cancer population. METHODS: A multicenter cross-sectional study was conducted with cancerpatients exposed to bisphosphonates for at least 7 months. Dental and periodontal conditions were assessed by epidemiological indices. RESULTS: The sample consisted of 80 patients under bisphosphonate therapy, nine of which were allocated to group 1 (with MRONJ) and 71 to group 2 (without MRONJ). Osteonecrosis cases presented 19 decayed, missing, and filled teeth on average. Moderate gingival inflammation was noted in both groups and together with severe inflammation exceeded 50% of the groups. The presence of dental calculus was detected in about half of the individuals in both groups. Shallow periodontal pockets were detected in about 25% of both groups. Deep periodontal pockets were more prevalent among patients with osteonecrosis. Regular oral hygiene was detected in approximately 25% of individuals in both groups. There was a strong positive correlation between the clinical staging of osteonecrosis and decayed, missing, and filled teeth index (DMFTI). CONCLUSIONS:Patients had a poor oral health condition. All but one osteonecrosis case had no previous history of tooth extraction; oral infections seemed to play a major role in the development of bone necrosis. Advanced osteonecrosis stages were associated with a higher DMFTI.
Authors: Thacharot Boonyapakorn; Ingrid Schirmer; Peter A Reichart; Isrid Sturm; Gero Massenkeil Journal: Oral Oncol Date: 2008-02-20 Impact factor: 5.337
Authors: Christian Walter; Bilal Al-Nawas; Knut A Grötz; Christian Thomas; Joachim W Thüroff; Viktoria Zinser; Heinold Gamm; Joachim Beck; Wilfried Wagner Journal: Eur Urol Date: 2008-06-26 Impact factor: 20.096