BACKGROUND: Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws. METHODS: Records of 638 patients treated with intravenous bisphosphonates were reviewed. Drug used, number of infusions, dosing interval, dosage, duration, and occasion of osteonecrosis, diagnosed by history and physical examination, were analyzed. RESULTS: The overall incidence of osteonecrosis was 0.94% (6/638). No significant relationship was observed between the incidence of osteonecrosis and demographic parameters, primary tumor, cumulative drug dose, or dosing interval. However, patients who developed osteonecrosis had a significantly greater mean number of infusions (p = .016) and significantly greater mean hours of infusion time (p = .0036). CONCLUSIONS: The findings suggest positive correlation between the development of osteonecrosis and drug exposure as measured by number of infusions and total infusion hours. However, the relatively low incidence of osteonecrosis precluded definition of a direct dose-response relationship.
BACKGROUND: Intravenous bisphosphonate therapy has been used for treatment of benign and malignant bone diseases and has been linked to osteonecrosis of the jaws. METHODS: Records of 638 patients treated with intravenous bisphosphonates were reviewed. Drug used, number of infusions, dosing interval, dosage, duration, and occasion of osteonecrosis, diagnosed by history and physical examination, were analyzed. RESULTS: The overall incidence of osteonecrosis was 0.94% (6/638). No significant relationship was observed between the incidence of osteonecrosis and demographic parameters, primary tumor, cumulative drug dose, or dosing interval. However, patients who developed osteonecrosis had a significantly greater mean number of infusions (p = .016) and significantly greater mean hours of infusion time (p = .0036). CONCLUSIONS: The findings suggest positive correlation between the development of osteonecrosis and drug exposure as measured by number of infusions and total infusion hours. However, the relatively low incidence of osteonecrosis precluded definition of a direct dose-response relationship.
Authors: Rogério Jardim Caldas; Héliton Spíndola Antunes; Camila de Oliveira Rodini Pegoraro; Fábio Ribeiro Guedes; Paulo Sérgio da Silva Santos Journal: Support Care Cancer Date: 2021-06-18 Impact factor: 3.603
Authors: Thomas Ziebart; Frank Halling; Paul Heymann; Andreas Neff; Sebastian Blatt; Junho Jung; Andreas Pabst; Leonardo Righesso; Christian Walter Journal: Dent J (Basel) Date: 2016-10-25
Authors: Petra Rugani; Christian Walter; Barbara Kirnbauer; Stephan Acham; Yvonne Begus-Nahrman; Norbert Jakse Journal: Dent J (Basel) Date: 2016-09-27