| Literature DB >> 34142093 |
Yuan-Hung Lo1, Kasper Karlsson1,2, Calvin J Kuo1.
Abstract
Organoid technologies enable the creation of in vitro physiologic systems that model tissues of origin more accurately than classical culture approaches. Seminal characteristics, including three-dimensional structure and recapitulation of self-renewal, differentiation, and disease pathology, render organoids eminently suited as hybrids that combine the experimental tractability of traditional 2D cell lines with cellular attributes of in vivo model systems. Here, we describe recent advances in this rapidly evolving field and their applications in cancer biology, clinical translation and precision medicine.Entities:
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Year: 2020 PMID： 34142093 PMCID： PMC8208643 DOI： 10.1038/s43018-020-0102-y
Source DB: PubMed Journal: Nat Cancer ISSN： 2662-1347