The modulatory effect of taurine on benzo (a) pyrene-induced hepatorenal toxicity.

Toxicities linked with Benzo (a) pyrene B[a]P exposure, particularly in liver and kidney have been reported in both animals and humans. Taurine (2-aminoethane sulfonic acid) is an intracellular β-amino acid reported to elicit hepatorenal protective functions. However, the modulatory effect of taurine on hepatorenal toxicity associated with exposure to B[a]P has not been reported. This study evaluated the effects of taurine on the hepatorenal toxicities induced in cohorts of rats exposed to B[a]P. Experimental rats were treated as follows: B[a]P (10 mg/kg); co-treated cohorts -B[a]P (10 mg/kg) plus taurine (100 or 200 mg/kg) for 4 successive weeks. Results show that co-dosing with taurine significantly (P < 0.05) improved B[a]P-induced distortion of oxidative stress markers (catalase, superoxide dismutase, glutathione S-transferase, glutathione peroxidase, total sulphydryl, reduced glutathione, lipid peroxidation and xanthine oxidase), renal function (urea and creatinine) and liver function marker enzymes (alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase and gamma glutamyl transferase). Moreover, taurine effectively mitigated increase in myeloperoxidase activity, levels of reactive oxygen and nitrogen species, nitric oxide and interleukin-1β in kidney and liver of rats treated with B[a]P. In conclusion, taurine modulates hepatorenal toxicity in B[a]P-exposed rats by suppressing hepatic and renal damage indices, oxidative injury and inflammatory stress.