Chih-Chen Hsu1, Yu-Chen Huang2,3,4, Syuan-Hao Syu1,5, Hung-Jen Shih1,5,6, Yung-Wei Lin1,5,7, Chi-Hao Hsiao1,5, Ke-Hsun Lin1, Liang-Ming Lee1,5, Yu-Ching Wen8,9,10. 1. Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 2. Department of Dermatology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 3. Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 4. Research center of big data and meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 5. Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 6. Department of Urology, Changhua Christian Hospital, Changhua, Taiwan. 7. College of Medicine International Master/Ph.D. Program in Medicine, Taipei Medical University, Taipei, Taiwan. 8. Department of Urology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. 95207@w.tmu.edu.tw. 9. Department of Urology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. 95207@w.tmu.edu.tw. 10. Taipei Medical University-Research Center of Urology and Kidney (TMU-RCUK), Taipei Medical University, Taipei, Taiwan. 95207@w.tmu.edu.tw.
Abstract
INTRODUCTION AND HYPOTHESIS: The association of vitamin D deficiency with female urinary incontinence is unclear. METHODS: A systematic review of English and non-English articles was conducted. All observational studies in databases including PubMed, EMBASE, the Cochrane Library Trials Register, and Google Scholar were searched until 5 October 2020. Additional studies were identified by contacting clinical experts and searching the bibliographies and abstracts of the compiled articles. Search terms included urinary incontinence and vitamin D. Article data, including study quality indicators, were independently extracted by two authors using predefined data fields. RESULTS: Two cohort studies, four case-control studies and five cross-sectional studies were included in the qualitative synthesis. Two cohort studies and one cross-sectional study, with a total of 2501 females, were included in the meta-analysis. Heterogeneity among the three studies was not observed (I2 = 0.0%, P = 0.69). All pooled analyses were based on fixed-effects models. No difference in vitamin D level was observed between the urinary incontinence group and the control group (mean difference 0.07 ng/ml; 95% confidence interval [CI] -0.57-0.72, P = 0.81, I2 = 0%). CONCLUSIONS: Our meta-analysis revealed that adult females with urinary incontinence did not have lower serum vitamin D levels than control females.
INTRODUCTION AND HYPOTHESIS: The association of vitamin D deficiency with female urinary incontinence is unclear. METHODS: A systematic review of English and non-English articles was conducted. All observational studies in databases including PubMed, EMBASE, the Cochrane Library Trials Register, and Google Scholar were searched until 5 October 2020. Additional studies were identified by contacting clinical experts and searching the bibliographies and abstracts of the compiled articles. Search terms included urinary incontinence and vitamin D. Article data, including study quality indicators, were independently extracted by two authors using predefined data fields. RESULTS: Two cohort studies, four case-control studies and five cross-sectional studies were included in the qualitative synthesis. Two cohort studies and one cross-sectional study, with a total of 2501 females, were included in the meta-analysis. Heterogeneity among the three studies was not observed (I2 = 0.0%, P = 0.69). All pooled analyses were based on fixed-effects models. No difference in vitamin D level was observed between the urinary incontinence group and the control group (mean difference 0.07 ng/ml; 95% confidence interval [CI] -0.57-0.72, P = 0.81, I2 = 0%). CONCLUSIONS: Our meta-analysis revealed that adult females with urinary incontinence did not have lower serum vitamin D levels than control females.
Authors: Carolyn W Swenson; Megan O Schimpf; Stacy B Menees; Hope K Haefner; Mitchell B Berger Journal: Int J Vitam Nutr Res Date: 2019-02-12 Impact factor: 1.784
Authors: Rob Riemsma; Suzanne Hagen; Ruth Kirschner-Hermanns; Christine Norton; Helle Wijk; Karl-Erik Andersson; Christopher Chapple; Julian Spinks; Adrian Wagg; Edward Hutt; Kate Misso; Sohan Deshpande; Jos Kleijnen; Ian Milsom Journal: BMC Med Date: 2017-03-24 Impact factor: 8.775