Yasemin Ustundag1, Karlıbel Lknur Aykurt2, Murat Sambel3, Murat Ozturk3, Atilla Satır3, Elif Yolgosteren2, Salim Neselioglu4, Ozcan Erel4. 1. Saglik Bilimleri University, Bursa Yuksek Ihtisas Education and Research Hospital, Department of Clinical Laboratory, Bursa, Turkey. 2. Saglik Bilimleri University, Bursa Yuksek Ihtisas Education and Research Hospital, Department of Physical Therapy and Rehabilitation, Bursa, Turkey. 3. Saglik Bilimleri University, Bursa Yuksek Ihtisas Education and Research Hospital, Department of Urology, Bursa, Turkey. 4. Ankara Yildirim Beyazit University, Clinical Biochemistry, Ankara, Turkey.
Abstract
BACKGROUND: This study aimed to find a relationship between vitamin D concentration and thiol-disulfide homeostasis in the pathophysiology of overactive bladder (OAB) syndrome in postmenopausal women. METHODS: A total of 76 postmenopausal women, referred for routine controls, were recruited between January and March 2018 to participate in this study. Participants with an overactive bladder questionnaire (OAB-q) score of >11 (n = 34) were included in the OAB syndrome group, while those with a score of <5 (n = 42) were included in the control group. Serum total antioxidant capacity, ischemia-modified albumin, C-reactive protein, 25-hydroxy vitamin D levels, and thiol-disulfide homeostasis were measured. RESULTS: Patients with OAB syndrome had waist circumferences of 106 ± 11 cm, and their body mass indexes (BMIs) were 30.8 ± 4.8 kg/m2. The control groups' waist circumferences were 102 ± 11 cm and their BMIs were 28.9 ± 4.3 kg/m2 (p = 0.069 and p = 0.098, respectively). The level of vitamin D in the control group was 33.7 (IQR: 30.7) nmol/L and 27.0 (IQR: 27.5) nmol/L (p = 0.081) in the OAB syndrome group. CONCLUSIONS: We were not able to demonstrate with certainty any significant relationships between serum 25-hydroxy vitamin D levels and thiol-disulfide homeostasis parameters and OAB syndrome. Society of Medical Biochemists of Serbia, Belgrade.
BACKGROUND: This study aimed to find a relationship between vitamin D concentration and thiol-disulfide homeostasis in the pathophysiology of overactive bladder (OAB) syndrome in postmenopausal women. METHODS: A total of 76 postmenopausal women, referred for routine controls, were recruited between January and March 2018 to participate in this study. Participants with an overactive bladder questionnaire (OAB-q) score of >11 (n = 34) were included in the OAB syndrome group, while those with a score of <5 (n = 42) were included in the control group. Serum total antioxidant capacity, ischemia-modified albumin, C-reactive protein, 25-hydroxy vitamin D levels, and thiol-disulfide homeostasis were measured. RESULTS: Patients with OAB syndrome had waist circumferences of 106 ± 11 cm, and their body mass indexes (BMIs) were 30.8 ± 4.8 kg/m2. The control groups' waist circumferences were 102 ± 11 cm and their BMIs were 28.9 ± 4.3 kg/m2 (p = 0.069 and p = 0.098, respectively). The level of vitamin D in the control group was 33.7 (IQR: 30.7) nmol/L and 27.0 (IQR: 27.5) nmol/L (p = 0.081) in the OAB syndrome group. CONCLUSIONS: We were not able to demonstrate with certainty any significant relationships between serum 25-hydroxy vitamin D levels and thiol-disulfide homeostasis parameters and OAB syndrome. Society of Medical Biochemists of Serbia, Belgrade.
Entities:
Keywords:
C-reactive protein; disulfides; overactive; postmenopause; urinary bladder; vitamin D
Authors: Wilke M Post; Alejandra M Ruiz-Zapata; Hilde Grens; Rob B M de Vries; Geert Poelmans; Marieke J H Coenen; Dick A W Janssen; John P F A Heesakkers; Egbert Oosterwijk; Kirsten B Kluivers Journal: Neurourol Urodyn Date: 2020-09-19 Impact factor: 2.696