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Literature DB >> 34131113

Rett mutations attenuate phase separation of MeCP2.

Chunyan Fan¹, Honglian Zhang¹, Liangzheng Fu^1,2, Yuejiao Li^1,2, Yi Du^1,2, Zilong Qiu^2,3,4, Falong Lu^5,6,7.

Abstract

Entities: Gene

Year: 2020 PMID： 34131113 DOI： 10.1038/s41421-020-0172-0

Source DB: PubMed Journal: Cell Discov ISSN： 2056-5968 Impact factor: 10.849

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13 in total

Review 1. Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.

Authors: Jeffrey C Hansen; Rajarshi P Ghosh; Christopher L Woodcock
Journal: IUBMB Life Date: 2010-10 Impact factor: 3.885

Review 2. Rett syndrome: clinical review and genetic update.

Authors: L S Weaving; C J Ellaway; J Gécz; J Christodoulou
Journal: J Med Genet Date: 2005-01 Impact factor: 6.318

3. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.

Authors: J D Lewis; R R Meehan; W J Henzel; I Maurer-Fogy; P Jeppesen; F Klein; A Bird
Journal: Cell Date: 1992-06-12 Impact factor: 41.582

4. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

Authors: R E Amir; I B Van den Veyver; M Wan; C Q Tran; U Francke; H Y Zoghbi
Journal: Nat Genet Date: 1999-10 Impact factor: 38.330

5. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions.

Authors: Noriyuki Kishi; Jeffrey D Macklis
Journal: Mol Cell Neurosci Date: 2004-11 Impact factor: 4.314

6. Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo.

Authors: Asmita Kumar; Sachin Kamboj; Barbara M Malone; Shinichi Kudo; Jeffery L Twiss; Kirk J Czymmek; Janine M LaSalle; N Carolyn Schanen
Journal: J Cell Sci Date: 2008-03-11 Impact factor: 5.285

Rett mutations attenuate phase separation of MeCP2.

Review 1. Binding of the Rett syndrome protein, MeCP2, to methylated and unmethylated DNA and chromatin.

Review 2. Rett syndrome: clinical review and genetic update.

3. Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.

4. Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2.

5. MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions.

6. Analysis of protein domains and Rett syndrome mutations indicate that multiple regions influence chromatin-binding dynamics of the chromatin-associated protein MECP2 in vivo.

Review 7. Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates.

8. The major form of MeCP2 has a novel N-terminus generated by alternative splicing.

9. Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.

Review 10. The distinct methylation landscape of maturing neurons and its role in Rett syndrome pathogenesis.