Literature DB >> 3412784

Antigenic cross-reactivity between the human whipworm, Trichuris trichiura, and the mouse trichuroids Trichuris muris and Trichinella spiralis.

T I Roach1, D Wakelin, K J Else, D A Bundy.   

Abstract

Cross-reactivity was demonstrated between circulating antibodies from Trichuris trichiura-infected humans and T. muris-infected mice for heterologous antigen preparations. Mouse immune sera raised against excretory/secretory (E/S) products and anterior end homogenate from adult T. muris showed marked affinity for T. trichiura adult homogenate in ELISA, and 35S-methionine-labelled adult T. muris E/S products were precipitated by T. trichiura infection sera. Monoclonal antibodies recognizing a 48 kD Trichinella spiralis muscle larval beta-stichocyte granule antigen also showed avidity for T. trichiura adult homogenate in ELISA, as did serum from mice with patent T. muris worm burdens. This cross-reactivity is thought to result from shared stichocyte antigens and the relevance of this observation is discussed.

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Year:  1988        PMID： 3412784     DOI： 10.1111/j.1365-3024.1988.tb00221.x

Source DB:  PubMed          Journal:  Parasite Immunol        ISSN： 0141-9838            Impact factor:   2.280


  18 in total

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Authors:  Pewpan M Intapan; Rutchanee Rodpai; Oranuch Sanpool; Tongjit Thanchomnang; Lakkhana Sadaow; Issarapong Phosuk; Wanchai Maleewong
Journal:  Parasitol Res       Date:  2017-06-30       Impact factor: 2.289

2.  Investigation of immunofluorescence cross-reactions against Trichinella spiralis by western blot (immunoblot) analysis.

Authors:  F Robert; B Weil; N Kassis; J Dupouy-Camet
Journal:  Clin Diagn Lab Immunol       Date:  1996-09

3.  Potential use of Trichinella spiralis antigen for serodiagnosis of human capillariasis philippinensis by immunoblot analysis.

Authors:  Pewpan M Intapan; Wanchai Maleewong; Wattana Sukeepaisarnjaroen; Nimit Morakote
Journal:  Parasitol Res       Date:  2005-12-07       Impact factor: 2.289

4.  Identification of diagnostic antigens from Trichinella spiralis.

Authors:  W L Homan; A C Derksen; F van Knapen
Journal:  Parasitol Res       Date:  1992       Impact factor: 2.289

5.  Peripheral cytokine responses to Trichuris muris reflect those occurring locally at the site of infection.

Authors:  M D Taylor; C J Betts; K J Else
Journal:  Infect Immun       Date:  2000-04       Impact factor: 3.441

6.  The specificity of the antibody response to internal antigens of Ascaris: heterogeneity in infected humans, and MHC (H-2) control of the repertoire in mice.

Authors:  M W Kennedy; L A Tomlinson; E M Fraser; J F Christie
Journal:  Clin Exp Immunol       Date:  1990-05       Impact factor: 4.330

7.  Validation of an enzyme-linked immunosorbent assay for diagnosis of human trichinellosis.

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8.  Development and evaluation of a Western blot kit for diagnosis of human trichinellosis.

Authors:  Hélène Yera; Shakir Andiva; Catherine Perret; Denis Limonne; Pascal Boireau; Jean Dupouy-Camet
Journal:  Clin Diagn Lab Immunol       Date:  2003-09

9.  Regulatory T cells: a role in the control of helminth-driven intestinal pathology and worm survival.

Authors:  Riccardo D'Elia; Jerzy M Behnke; Janette E Bradley; Kathryn J Else
Journal:  J Immunol       Date:  2009-02-15       Impact factor: 5.422

10.  Molecular and functional characterization of a recombinant protein of Trichuris trichiura.

Authors:  L J Drake; G C Barker; Y Korchev; M Lab; H Brooks; D A Bundy
Journal:  Proc Biol Sci       Date:  1998-08-22       Impact factor: 5.349
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