Abadi K Gebre1, Marc Sim2, Alexander J Rodríguez3, Jonathan M Hodgson4, Lauren C Blekkenhorst4, Pawel Szulc5, Nicola Bondonno6, Kun Zhu7, Catherine Bondonno4, Douglas P Kiel8, John T Schousboe9, Richard L Prince7, Joshua R Lewis10. 1. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; School of Pharmacy, College of Health Sciences, Mekelle University, Mekelle, Tigray, 1871, Ethiopia. 2. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; Medical School, The University of Western Australia, Perth, WA, 6000, Australia. Electronic address: marc.sim@ecu.edu.au. 3. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; Bone and Muscle Health Research Group, Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia. 4. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; Medical School, The University of Western Australia, Perth, WA, 6000, Australia. 5. INSERM UMR1033, University of Lyon, Lyon, France. 6. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; School of Biomedical Sciences, The University of Western Australia, Perth, WA, 6000, Australia. 7. Medical School, The University of Western Australia, Perth, WA, 6000, Australia; Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands, WA, 6009, Australia. 8. Marcus Institute for Aging Research, Hebrew SeniorLife, Department of Medicine Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA. 9. Park Nicollet Osteoporosis Center and HealthPartners Institute, HealthPartners, Minneapolis, MN 55416, USA; Division of Health Policy and Management, University of Minnesota, Minneapolis, MN 55455, USA. 10. Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 6027, Australia; Medical School, The University of Western Australia, Perth, WA, 6000, Australia; Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, NSW, 2145, Australia.
Abstract
BACKGROUNDS AND AIMS: Abdominal aortic calcification (AAC) is associated with weaker grip strength, an established risk factor for fall-related hospitalizations. However, its association with long-term fall-related hospitalisations remains unknown. This study investigated the association between AAC and long-term fall-related hospitalizations in community-dwelling older women. METHODS: Fall-related hospitalizations were obtained from linked data over 14.5-years in a prospective cohort of 1053 older women (mean age 75.0 ± 2.6 years). At baseline (1998/99), AAC was assessed from lateral spine images obtained using dual-energy X-ray absorptiometry, and scored using a semi-quantitative method (AAC24, range 0-24). The presence of any AAC was defined by AAC24 ≥ 1. RESULTS: Over 14.5-years, 413 (39.2%) women experienced a fall-related hospitalization. In the multivariable-adjusted model, each unit increase in baseline AAC24 was associated with a 3% increase in relative hazards for a fall-related hospitalization (HR 1.03 95%CI, 1.01 to 1.07). Compared to women with no AAC, women with any AAC had a 40% (HR 1.40 95%CI, 1.11 to 1.76) and 39% (HR 1.39 95%CI, 1.10 to 1.76) greater risk for fall-related hospitalizations in the minimal and multivariable-adjusted models, respectively. This relationship was not attenuated by including measures of muscle function such as grip strength and timed-up-and-go. CONCLUSIONS: The presence of AAC is associated with long-term fall-related hospitalizations risk, independent of muscle function, in community-dwelling older women. Concurrent assessment of AAC may be a simple and cost-effective way to identify older women at higher risk of falling as part of routine osteoporosis screening.
BACKGROUNDS AND AIMS: Abdominal aortic calcification (AAC) is associated with weaker grip strength, an established risk factor for fall-related hospitalizations. However, its association with long-term fall-related hospitalisations remains unknown. This study investigated the association between AAC and long-term fall-related hospitalizations in community-dwelling older women. METHODS: Fall-related hospitalizations were obtained from linked data over 14.5-years in a prospective cohort of 1053 older women (mean age 75.0 ± 2.6 years). At baseline (1998/99), AAC was assessed from lateral spine images obtained using dual-energy X-ray absorptiometry, and scored using a semi-quantitative method (AAC24, range 0-24). The presence of any AAC was defined by AAC24 ≥ 1. RESULTS: Over 14.5-years, 413 (39.2%) women experienced a fall-related hospitalization. In the multivariable-adjusted model, each unit increase in baseline AAC24 was associated with a 3% increase in relative hazards for a fall-related hospitalization (HR 1.03 95%CI, 1.01 to 1.07). Compared to women with no AAC, women with any AAC had a 40% (HR 1.40 95%CI, 1.11 to 1.76) and 39% (HR 1.39 95%CI, 1.10 to 1.76) greater risk for fall-related hospitalizations in the minimal and multivariable-adjusted models, respectively. This relationship was not attenuated by including measures of muscle function such as grip strength and timed-up-and-go. CONCLUSIONS: The presence of AAC is associated with long-term fall-related hospitalizations risk, independent of muscle function, in community-dwelling older women. Concurrent assessment of AAC may be a simple and cost-effective way to identify older women at higher risk of falling as part of routine osteoporosis screening.
Authors: Marc Sim; Lauren C Blekkenhorst; Joshua R Lewis; Catherine P Bondonno; Amanda Devine; Kun Zhu; Richard J Woodman; Richard L Prince; Jonathan M Hodgson Journal: Br J Nutr Date: 2018-08-29 Impact factor: 3.718
Authors: Joshua R Lewis; John T Schousboe; Wai H Lim; Germaine Wong; Kevin E Wilson; Kun Zhu; Peter L Thompson; Douglas P Kiel; Richard L Prince Journal: J Bone Miner Res Date: 2018-03-25 Impact factor: 6.741
Authors: M Sim; R L Prince; D Scott; R M Daly; G Duque; C A Inderjeeth; K Zhu; R J Woodman; J M Hodgson; J R Lewis Journal: Osteoporos Int Date: 2018-11-19 Impact factor: 4.507
Authors: Carrie Hanley; Kelly J Shields; Karen A Matthews; Maria M Brooks; Imke Janssen; Matthew J Budoff; Akira Sekikawa; Suresh Mulukutla; Samar R El Khoudary Journal: Atherosclerosis Date: 2018-09-08 Impact factor: 5.162
Authors: Antonio Bellasi; Luca Di Lullo; Domenico Russo; Roberto Ciarcia; Michele Magnocavallo; Carlo Lavalle; Carlo Ratti; Maria Fusaro; Mario Cozzolino; Biagio Raffaele Di Iorio Journal: J Clin Med Date: 2021-01-20 Impact factor: 4.241
Authors: Joshua R Lewis; Wai Lim; Satvinder S Dhaliwal; Kun Zhu; Ee Mun Lim; Peter L Thompson; Richard L Prince Journal: BMC Nephrol Date: 2012-07-16 Impact factor: 2.388
Authors: Ayse Zengin; Cat Shore-Lorenti; Marc Sim; Louise Maple-Brown; Sharon Lee Brennan-Olsen; Joshua R Lewis; Jennifer Ockwell; Troy Walker; David Scott; Peter Ebeling Journal: BMJ Open Date: 2022-04-04 Impact factor: 2.692