Literature DB >> 34110842

Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.

Danielle M Dick1, Trisha Saunders2, Emily Balcke1, Morgan N Driver3, Zoe Neale1, Jasmin Vassileva4, Joshua M Langberg1.   

Abstract

Objective: Risky substance use among college students is widespread, and associated with numerous adverse consequences. Current interventions focus primarily on students' current substance use; we hypothesize that shifting focus from current use to underlying risk factors is a complementary approach that may improve effectiveness of prevention/intervention programming. This approach aligns with the personalized medicine movement, which aims to harness knowledge about underlying etiological factors to provide individuals with specific information about their unique risk profiles and personalized recommendations, to motivate and enable individuals to better self-regulate their health. Method: Our group is building and evaluating an online Personalized Feedback Program (PFP) for college students that provides feedback about the individual's underlying genetically influenced externalizing and internalizing risk factors for substance use, along with personalized recommendations/resources. The project capitalizes on work from a university-wide research project (Spit for Science; S4S), in which > 12,000 students (˜70% of 5 years of incoming freshmen) are being followed longitudinally to assess substance use and related factors across the college years. In this article, we describe our foundational work to develop the PFP.
Results: From the S4S data, we have identified risk factors across four domains (Sensation Seeking, Impulsivity, Extraversion, and Neuroticism) that are correlated with college students' substance use. We developed an online self-guided PFP, in collaboration with professionals from student affairs, and using feedback from students, with the ultimate goal of conducting a randomized clinical trial.
Conclusion: The provision of personalized risk information represents a novel approach to complement and extend existing college substance use programming. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

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Year:  2021        PMID: 34110842      PMCID: PMC8660940          DOI: 10.1037/adb0000759

Source DB:  PubMed          Journal:  Psychol Addict Behav        ISSN: 0893-164X


  88 in total

1.  A randomized controlled trial of a behavioral economic supplement to brief motivational interventions for college drinking.

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2.  The individual within the group: balancing the need to belong with the need to be different.

Authors:  Matthew J Hornsey; Jolanda Jetten
Journal:  Pers Soc Psychol Rev       Date:  2004

3.  Brief motivational interventions for college student drinking may not be as powerful as we think: an individual participant-level data meta-analysis.

Authors:  David Huh; Eun-Young Mun; Mary E Larimer; Helene R White; Anne E Ray; Isaac C Rhew; Su-Young Kim; Yang Jiao; David C Atkins
Journal:  Alcohol Clin Exp Res       Date:  2015-05       Impact factor: 3.455

4.  From translational neuroscience to personalized medicine.

Authors:  John H Krystal; Stephanie S O'Malley
Journal:  Alcohol Clin Exp Res       Date:  2015-02-06       Impact factor: 3.455

5.  Types of alcoholics, I. Evidence for an empirically derived typology based on indicators of vulnerability and severity.

Authors:  T F Babor; M Hofmann; F K DelBoca; V Hesselbrock; R E Meyer; Z S Dolinsky; B Rounsaville
Journal:  Arch Gen Psychiatry       Date:  1992-08

6.  A randomized clinical trial evaluating the efficacy of a brief alcohol intervention supplemented with a substance-free activity session or relaxation training.

Authors:  James G Murphy; Ashley A Dennhardt; Matthew P Martens; Brian Borsari; Katie Witkiewitz; Lidia Z Meshesha
Journal:  J Consult Clin Psychol       Date:  2019-05-09

7.  Alcohol dependence is related to overall internalizing psychopathology load rather than to particular internalizing disorders: evidence from a national sample.

Authors:  Matt G Kushner; Melanie M Wall; Robert F Krueger; Kenneth J Sher; Eric Maurer; Paul Thuras; Susanne Lee
Journal:  Alcohol Clin Exp Res       Date:  2011-09-06       Impact factor: 3.455

8.  Drug use patterns and continuous enrollment in college: results from a longitudinal study.

Authors:  Amelia M Arria; Laura M Garnier-Dykstra; Kimberly M Caldeira; Kathryn B Vincent; Emily R Winick; Kevin E O'Grady
Journal:  J Stud Alcohol Drugs       Date:  2013-01       Impact factor: 2.582

9.  Personalized medicine: a patient-centered paradigm.

Authors:  Lotfi Chouchane; Ravinder Mamtani; Ashraf Dallol; Javaid I Sheikh
Journal:  J Transl Med       Date:  2011-12-01       Impact factor: 5.531

Review 10.  Impulsive delayed reward discounting as a genetically-influenced target for drug abuse prevention: a critical evaluation.

Authors:  Joshua C Gray; James MacKillop
Journal:  Front Psychol       Date:  2015-09-01
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  1 in total

1.  Age varying polygenic effects on alcohol use in African Americans and European Americans from adolescence to adulthood.

Authors:  Kit K Elam; Thao Ha; Zoe Neale; Fazil Aliev; Danielle Dick; Kathryn Lemery-Chalfant
Journal:  Sci Rep       Date:  2021-11-17       Impact factor: 4.379

  1 in total

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