Current Perspectives on the Systemic Management of Atopic Dermatitis.

Atopic dermatitis (AD) is a common disease of childhood, and some patients experience a prolonged clinical course into adolescence and adulthood. Systemic management is required when AD is not adequately controlled with topical medications. Our aim is to provide a comprehensive review of commonly used systemic immunomodulating agents in childhood and adult AD, including cyclosporine A (CsA), azathioprine (AZA), methotrexate (MTX) and mycophenolate mofetil (MMF), which are prescribed off-label in the United States, as well as dupilumab, an FDA-approved biologic. We will also provide a brief overview of emerging systemic therapies currently under investigation.

Introduction

Atopic dermatitis (AD) is an inflammatory skin disorder affecting up to 20% of children and 10% of adults worldwide.1–4 In the United States, the estimated annual cost of AD was $4.228 billion in 2004, which is the equivalent of approximately $5.972 billion in 2021.5,6 The amount of out-of-pocket costs for patients with AD is high, and this burden increases with disease severity.7 Quality of life is significantly impacted in patients and their families, and is also correlated with disease severity.8 Diagnosis of AD is made based on clinical signs and symptoms, and the lack of uniform diagnostic criteria and availability of an objective test to confirm diagnosis impacts prevalence estimates. The Hanifin and Rajka criteria is the most widely used diagnostic criteria, followed by the United Kingdom Working Party criteria.9–11 Common clinical features of AD include pruritus, xerosis, lichenification, flexural involvement, disease course influenced by emotional and/or environmental factors, and early onset of disease.12 Numerous measures for AD severity have been established, such as the Eczema Area and Severity Index (EASI) and the Severity Scoring of Atopic Dermatitis index (SCORAD), which are the best validated and used to assess the clinical severity of AD.13 For the EASI and SCORAD clinical signs are typically assessed by a physician, while the Patient-Oriented Eczema Measure (POEM) is a preferred tool for patient-reported outcomes.14

The three main phases of AD are infantile, childhood, and adult. Since the use of systemic agents in infantile AD is rarely advised, the focus of this review will be on the childhood and adult phases.15 The infantile phase may manifest from birth to 2 years of age, followed by the childhood phase from 2 years through puberty. The adult phase begins at puberty and may persist throughout adulthood.16 AD is part of the “atopic march”, which is an association and potential progression of allergic conditions that develop during infancy and childhood when allergen exposure through inflamed skin may trigger an immunologic response. While not all atopic individuals progress through all features, the atopic march classically begins with AD, followed by IgE-mediated food allergies, asthma and allergic rhinitis.17

Childhood AD exhibits lichenified papules and plaques on the hands, feet, wrists and ankles, as well as the antecubital and popliteal regions. Localization at flexural areas is common, although extensor surfaces may be primarily involved in some patients. When there is facial involvement, it tends to affect the periorbital and perioral areas.16 In African American children, the lesions are often more papular and severe compared to white children, with structural racism contributing to this disparity.16,18 Adult AD is characterized by dry scaling erythematous papules and plaques, as well as the formation of large lichenified plaques representing chronic disease. The affected areas include the flexural folds, face and neck, upper arms and back, and dorsa of the hands, fingers, feet and toes.16 Persistence of AD into adulthood is common and is particularly prevalent in those with early onset, allergic rhinitis, and hand eczema in childhood.19

Pathogenesis

The pathogenesis of AD is multifactorial and involves a strong genetic component, dysfunctional epidermal barrier and type-2-dominated cutaneous inflammation.20 Loss-of-function genetic variants in the gene encoding filaggrin (FLG) predispose individuals to AD. Filaggrin is a protein that facilitates formation of the skin barrier, preventing epidermal water loss and impeding the entry of allergens, toxic chemicals, and infectious organisms.21 Barrier dysfunction may also be caused by mechanical damage, such as repetitive scratching, and alterations in the skin microbiome that lead to increased Staphylococcus aureus colonization and susceptibility to cutaneous infections.22,23 Cutaneous inflammation in AD is skewed towards TH2 cell-mediated pathways, with activated TH2 cells releasing IL-4 and IL-13, which promotes B cell IgE class switching and production of antigen-specific IgE.24 The goal of AD management is to control inflammation, improve symptoms and achieve long-term disease control. While most patients with AD are effectively managed with topical medications, others may require systemic therapy. Our aim is to provide a comprehensive review of commonly used systemic immunomodulating agents in childhood and adult AD, which broadly target cutaneous inflammation, as well as a brief overview of emerging systemic therapies that target specific aspects of AD pathogenesis.

Literature Search

A systematic search of the PubMed database was performed to identify contributions associated with systemic treatment of childhood and adult AD. Searches were limited to publications in the English language. MeSH terms used in various combinations in the literature search included: atopic dermatitis, eczema, treatment, systemic therapy, emerging therapy, cyclosporine A, azathioprine, methotrexate, mycophenolate mofetil, dupilumab, tralokinumab, lebrikizumab, nemolizumab, fezakinumab, baricitinib, upadacitinib, and abrocitinib. ClinicalTrials.gov was explored using the terms atopic dermatitis, dupilumab, tralokinumab, lebrikizumab, nemolizumab, fezakinumab, baricitinib, upadacitinib, and abrocitinib.

Systemic Therapy

Systemic therapy is required to control skin inflammation, reduce symptoms, prevent flares, and improve quality of life in children and adults with moderate to severe AD that does not respond to maximized topical therapies.25 A consensus statement from the International Eczema Council recommends that prior to prescribing systemic therapy, physicians should consider alternate or concomitant diagnoses, avoid triggering factors, optimize topical therapy, ensure adequate patient/caregiver education, treat coexistent infection, assess the impact on quality of life, and consider phototherapy.25 Commonly used conventional systemic immunomodulating agents include cyclosporine A (CsA), azathioprine (AZA), methotrexate (MTX), and mycophenolate mofetil (MMF), which are prescribed off-label in the US. Dupilumab is an FDA-approved biologic indicated for the treatment of moderate to severe AD in patients aged 6 years and older.26 Many additional biologic and small-molecule medications, such as oral Janus kinase (JAK) inhibitors, are being investigated in clinical trials. We will not discuss systemic corticosteroids, since they are not recommended and their use should be reserved for acute, severe exacerbations as a short-term bridge to another systemic, steroid-sparing agent.27 Systemic antibiotics and antiviral agents are recommended in patients with bacterial infections and eczema herpeticum, respectively.27

Systematic reviews and meta-analyses comparing systemic therapies have shown that CsA and dupilumab may have superior short-term effectiveness compared to MTX and AZA for the treatment of adult AD.28,29 A survey completed by dermatologists from 30 European countries revealed that CsA was the preferred first-line conventional systemic therapy, while AZA and MTX were selected as second-line treatments. Conventional systemic therapy options offered in the survey were CsA, AZA, MTX, MMF and oral corticosteroids, while dupilumab was not included.30 In 2014, prior to the approval of dupilumab, another survey completed by members of the Society for Pediatric Dermatology in the US and Canada showed that the most commonly chosen first-line agents were CsA and MTX, second-line agents were MTX and MMF, and third-line agents were AZA and MMF.31 With the exception of dupilumab, systemic immunomodulating agents do not have formal dosing guidelines for AD and require laboratory monitoring (Table 1). Regardless of general prescribing practices, the choice of systemic therapy should be based on each individual patient’s needs. Ultimately, physicians should engage in shared decision-making with their patients, taking into account efficacy and safety, as well as convenience and cost when prescribing systemic therapies.

Table 1

Mechanism, Dosing, and Monitoring of Systemic Therapiesa

Systemic Agent	Mechanism	Starting Dose	Dose Adjustment	Baseline Assessment	Follow-Up Monitoring	Historic FDA Pregnancy Risk Categoryb	Newer Pregnancy Ratingb
Cyclosporine A (CsA)32	Inhibits production of IL-2 resulting in decreased T-cell proliferation	1. Initial high dose regimen: 5 mg/kg daily in two divided doses for 2–3 months	1. Initial high dose regimen: Reduce in decrements of 1 mg/kg daily every other week until the minimum effective dose is reached	2 blood pressures at least a day apart; 2 serum creatinine levels at least a day apart; BUN; CBC; LFTs; fasting lipids; magnesium; potassium; uric acid	Blood pressure at each visit every 2 weeks for 1–2 months, then every 4–6 weeks; labs every 2 weeks for the first 1–2 months, then monthly; labs should include serum creatinine, BUN, urinalysis, CBC, LFTs, lipids, magnesium, potassium, uric acid	Category C	Probably compatible
		2. Initial low dose regimen: 2.5–3 mg/kg daily for 1 month	2. Initial low dose regimen: Increase in increments of 0.5–1 mg/kg daily every 2 weeks, not to exceed the maximum dose of 5 mg/kg daily
Azathioprine (AZA)41	Inhibits purine metabolism and cell division via incorporation into DNA and RNA	1. Low TPMT (<6.3 U/mL): Do not use AZA	Consider rechecking TPMT level if a sudden change in efficacy occurs	Pregnancy test; CBC with platelet count; CMP; urinalysis; tuberculosis testing; TPMT function assay	Labs every 2 weeks for the first 2 months, then every 2–3 months; labs should include CBC with differential and LFTs	Category D	Low risk (second trimester); Moderate-high risk (third trimester)
		2. Intermediate TPMT (6.3 to 15 U/mL): Up to 1 mg/kg daily
		3. High TPMT (>15.1 to 26.4 U/mL): Up to 2–3 mg/kg daily
Methotrexate (MTX)49	Inhibits dihydrofolate reductase (DHFR) resulting in decreased DNA and RNA synthesis and proliferation of lymphocytes	Doses should be administered weekly in a single weekly dose or three divided doses over a 24-hour period. Initiate with a dose of 0.3–0.5 mg/kg.	Increase in increments of 2.5–5 mg every week. When maximal benefit is achieved (total weekly dose rarely exceeds 30 mg) taper by 2.5 mg every week until the minimum effective dose is reached.	CBC with platelet count; LFTs; serologic tests for hepatitis B and C; BUN; serum creatinine; HIV testing in patients at risk for AIDS; tuberculosis testing in at risk patients	CBC with platelet count and LFTs after the first 2–4 weeks, 4 weeks after dose escalations, then every 3–4 months; BUN and serum creatinine once or twice yearly	Category X	Contraindicated
Mycophenolate mofetil (MMF)57	Inhibits inosine monophosphate dehydrogenase (IMPDH) resulting in decreased purine synthesis and proliferation of lymphocytes	Initiate with a dose of 20 mg/kg daily in two divided doses	If needed, increase to 40–50 mg/kg daily in two divided doses	Pregnancy test; CBC with differential and platelet count; CMP; LFTs; serologic tests for hepatitis B and C; tuberculosis testing	Consider monthly pregnancy test; labs every 4 weeks following dose escalation, then every 2–3 months; labs should include CBC with differential and platelet count, CMP, LFTs	Category D	Moderate-high risk
Dupilumab26,64	Binds the IL-4 receptor α-subunit, which blocks downstream signaling of IL-4 and IL-13	Adults: Initiate with a dose of 600 mg (two 300 mg injections in different injection sites)	Adults: 300 mg every other week	None	None	Unrated	No Data
		Pediatric Patients: 1. (15 to <30kg): Initiate with a dose of 600 mg (two 300 mg injections)	Pediatric Patients: 1. (15 to <30kg): 300 mg every 4 weeks
		2. (30 to 60kg): Initiate with a dose of 400 mg (two 200 mg injections)	2. (30 to <60kg): 200 mg every other week
		3. (60kg or more): Initiate with a dose of 600 mg (two 300 mg injections)	3. (60kg or more): 300 mg every other week

Notes: Symbols: α, alpha; ≤, less than; ≥, greater than. aFor CsA, AZA, MTX and MMF there are no formal dosing or monitoring guidelines for atopic dermatitis. Recommendations vary and are based on other inflammatory conditions. Those presented here are drawn from Comprehensive Dermatologic Drug Therapy (Fourth Edition), 2021, as well as the authors’ experience. bOn June 30, 2015, the FDA made the Pregnancy and Lactation Labeling Rule (PLLR) effective for prescription drug labeling. The rule required the removal of pregnancy categories A, B, C, D and X from human prescription drug and biologic product labeling. The new labeling includes descriptive information regarding risks.

Abbreviations: BUN, blood urea nitrogen; CBC, complete blood count; LFTs, liver function tests; CMP, complete metabolic panel; HIV, human immunodeficiency virus; AIDS, acquired immunodeficiency syndrome.

Cyclosporine A (CsA)

CsA is a potent immunosuppressive agent that inhibits calcineurin via a complex formed between CsA and cyclophilin. Calcineurin inhibition leads to reduced transcription of IL-2, which results in a decline in the number of activated CD4+ and CD8+ T-cells in the epidermis.32 It is indicated for the prevention of organ rejection in kidney, liver, and heart allogeneic transplants. It is also indicated for the treatment of patients with rheumatoid arthritis that have not adequately responded to MTX and for patients with plaque psoriasis who have failed to respond to at least one systemic therapy.33 CsA is an effective off-label treatment for childhood and adult AD, and it is approved to treat adult AD in Europe.32 A double-blind, placebo-controlled, crossover RCT of 33 adults with severe refractory AD showed significant improvements in disease activity and extent of disease scores with 8 weeks of treatment compared to placebo. Once CsA was stopped, relapse was rapid, but the mean scores for disease activity and extent of disease were less than their baseline values.34 Another double-blind, placebo-controlled RCT of 46 adults with severe AD showed significant improvements in disease severity, extent of disease, lichenification, itch, and loss of sleep with 6 weeks of treatment compared to placebo.35 An open, uncontrolled study of 43 adults with severe AD studying the length of remission with CsA treatment suggested that while a significant decrease in disease activity was observed after 6 weeks of CsA, most patients relapsed a few weeks after treatment ended.36 An open, uncontrolled study of 27 children aged 2 to 16 years with severe refractory AD demonstrated a significant improvement in disease activity and quality of life with 6 weeks of treatment. Most children relapsed within a few weeks of stopping treatment, however, persistent improvement was observed after 6 months of follow-up in 3 children.37 An open RCT of 43 children aged 2 to 16 years with severe refractory AD comparing multiple short courses of CsA with continuous therapy for 1 year revealed that more consistent AD control was achieved with continuous treatment. However, short course therapy was adequate for some patients, indicating that treatment should be tailored to individual patient’s needs.38 A case series of 5 children aged 10 to 14 years with severe AD demonstrated that weekend CsA maintenance therapy may be an option in pediatric patients requiring CsA treatment longer than 1 year. Intermittent therapy on Saturdays and Sundays for 20 weeks resulted in a reduction in the cumulative dose of CsA and serum CsA levels without the loss of clinical benefits.39 A systematic review of 15 studies including 602 children and adults with AD showed a mean clinical improvement of about 55% after 6 to 8 weeks of CsA treatment. Studies analyzing the stability of therapy showed that 50% of patients relapsed within 2 weeks and 80% within 6 weeks after stopping treatment.40

Adverse reactions of CsA include renal dysfunction, headache, hypertension, hypertriglyceridemia, hirsutism/hypertrichosis, paresthesia or hyperesthesia, influenza-like symptoms, gastrointestinal (GI) disturbances, lethargy, musculoskeletal or joint pain, and gingival hypertrophy. Due to an increased risk of skin and lymphoproliferative malignancies, patients should not be treated concurrently with CsA and phototherapy, and photoprotection should be advised.33 In the systematic review of patients with AD treated with CsA, higher initial doses led to a more rapid response, however, withdrawals from treatment due to adverse events were more likely in patients treated with higher initial doses. The adverse events included GI symptoms, infections, paresthesia and headaches, as well as increases in creatinine and blood pressure. Interestingly, while the effectiveness of CsA in adults and children was similar, tolerability appeared better in children.40

There is robust evidence that CsA is effective in the management of children and adults with severe AD. It has a rapid onset of action and an acceptable short-term adverse effect profile. However, relapse is common upon discontinuation of treatment, and potential long-term side effects are concerning.

Azathioprine (AZA)

AZA is a purine analog that inhibits purine metabolism and cell division when incorporated into DNA and RNA. It also interferes with T-cell, B-cell, and antigen-presenting cell functions.41 It is indicated as an adjunct for the prevention of rejection in renal homotransplantations and for the management of active rheumatoid arthritis.42 AZA may be used as an off-label treatment for childhood and adult AD.41 A double-blind, placebo-controlled, crossover RCT of 37 adults with severe AD showed significant improvements in Six Area, Six Sign Atopic Dermatitis (SASSAD) scores, pruritus, sleep disturbance, and disruption of work and daytime activities during 3 months of treatment compared to placebo.43 Another double-blind, placebo-controlled RCT of 63 adults with moderate to severe AD showed significant improvements in SASSAD scores, body area affected, itch score, global response, and quality of life with 3 months of treatment compared to placebo.44 In a case series of 28 children aged 3 to 17 years with severe AD, 61% of patients reported significant improvement while being treated with AZA and 21% reported some improvement. Patients that responded to AZA treatment experienced an initial improvement at a mean duration of 5.3 weeks.45

Adverse reactions of AZA include myelosuppression, GI disturbances, and hepatotoxicity. A GI hypersensitivity reaction characterized by nausea and vomiting may develop within the first several weeks of therapy, which is reversible upon discontinuation of the drug. There is an increased risk of malignancy, including post-transplant lymphoma and hepatosplenic T-cell lymphoma, which have been reported in patients with inflammatory bowel disease. Photoprotection should be advised due to increased risk for skin cancer.42 AZA is metabolized via three competing pathways, and is either anabolized to its active form by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), or degraded to inactive metabolites by thiopurine methyltransferase (TPMT) or xanthine oxidase (XO). TPMT activity is controlled by a genetic polymorphism, and patients can have high activity, intermediate activity, or low activity.41 Patients with intermediate TPMT activity may be at increased risk of myelotoxicity, while those with low or absent TPMT activity are at increased risk of developing severe, life-threatening myelotoxicity. Therefore, TPMT genotyping or phenotyping (red blood cell TPMT activity) is recommended to identify patients who are at increased risk of toxicity.42 In the RCT of 63 adults with moderate to severe AD, TPMT-based dosing seemed to reduce toxicity while maintaining efficacy.44 A retrospective study of 91 children aged 6 to 16 years with severe AD showed that AZA had an acceptable short-term adverse effect profile in those with normal TPMT activity.46 Case reports demonstrated that children with severe AD and intermediate TPMT activity responded to treatment with AZA at half-standard doses without any adverse events.47 A prospective study of 12 children aged 2 to 18 years with severe, recalcitrant AD revealed that TPMT activity may change during AZA treatment, suggesting that repeated measurement may be useful to optimize dosing.48

AZA has been shown to be effective in the management of children and adults with severe AD. It has a favorable safety profile when TPMT function testing is conducted prior to treatment to guide dosing.

Methotrexate (MTX)

MTX is a folic acid antagonist that inhibits dihydrofolate reductase (DHFR), preventing the conversion of dihydrofolate to tetrahydrofolate. This interferes with DNA and RNA synthesis, as well as the proliferation of lymphocytes.49 It is indicated in the treatment of neoplastic diseases such as gestational choriocarcinoma, breast cancer, lung cancer, and non-Hodgkin lymphomas. It is also indicated in the symptomatic control of psoriasis that is not responsive to other forms of therapy, active rheumatoid arthritis, and polyarticular-course juvenile rheumatoid arthritis that is not responsive to first-line therapy.50 MTX may be used as an off-label treatment for recalcitrant childhood and adult AD.49 An open-label, dose-ranging, prospective trial of 12 adults with moderate to severe AD treated with MTX for 24 weeks demonstrated an improvement in disease activity of 52% from baseline, with the majority of improvement observed by week 12.51 A single-blind RCT of 42 adults with severe AD comparing treatment with MTX versus AZA and showed a mean SCORAD reduction of 42% in the MTX arm and a reduction of 39% in the AZA arm after 12 weeks.52 To assess the long-term efficacy and safety of MTX and AZA, the 42 patients were asked to participate in an open-label follow-up study for 5 years, which demonstrated that both MTX and AZA seem to be effective and safe as maintenance treatments.53,54 An RCT of 97 adults with moderate to severe AD comparing treatment with MTX versus CsA demonstrated that while MTX was less efficient than CsA at lower doses, when the doses of both drugs were increased this led to an EASI reduction of 92% in the MTX arm versus a reduction of 87% in the CsA arm.55 An RCT of 40 children aged 7 to 14 years with severe AD comparing treatment with MTX versus CsA showed a mean SCORAD reduction of 26% in the MTX arm and a reduction of 25% in the CsA arm after 12 weeks. MTX had a delayed onset of action compared to CsA, however, the efficacy of MTX was prolonged.56

Common adverse reactions of MTX include ulcerative stomatitis, leukopenia, GI disturbances, malaise, chills and fever, dizziness and decreased resistance to infection. Serious adverse reactions include myelosuppression, hepatotoxicity, methotrexate-induced lung disease, and acute renal failure. Certain side effects may be reduced by folate supplementation.50 The RCT of adults with severe AD comparing treatment with MTX versus AZA and showed that mild myelosuppression was more frequent in the AZA arm, with otherwise similar rates of non-severe adverse events.52 The RCT of adults with moderate to severe AD comparing treatment with MTX versus CsA revealed that the number of adverse events was significantly higher in the CsA arm (55%) compared to the MTX arm (30%).55 The RCT of children with severe AD comparing treatment with MTX versus CsA showed that the safety profile of both drugs were similar. Common side effects in the MTX arm included anemia, fatigue, abnormal liver functions, nausea and vomiting, and glossitis with oral ulceration. All adverse events resolved at the end of a 12 week follow-up period.56

While MTX has demonstrated similar efficacy to CsA and AZA in the management of childhood and adult AD, it has not been studied as extensively. CsA led to a more rapid clinical improvement in children, however, the effects of MTX were longer-lasting. MTX is generally well tolerated, and in adults, the number of adverse events with MTX may be lower compared to CsA.

Mycophenolate Mofetil (MMF)

MMF is an immunosuppressant that inhibits inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the de novo pathway of purine synthesis. This inhibition leads to reduced lymphocyte proliferation.57 It is indicated for the prophylaxis of organ rejection, in recipients of allogeneic kidney, heart or liver transplants.58 MMF may be used as an off-label treatment for recalcitrant childhood and adult AD.57 A single-blind RCT of 55 adults with severe AD comparing treatment with MMF versus CsA showed that while the initial clinical response to MMF was delayed compared to that of CsA, clinical remission lasted longer for patients treated with MMF during a 12 week follow-up period.59 An open-label pilot study of 10 adults with moderate to severe AD showed that 7 patients had cleared completely after 4 weeks of MMF treatment and 6 patients had lasting remission at the end of a 20 week follow-up period.60 In another open-label pilot study, 10 adults with severe AD achieved a mean SCORAD improvement of 68% with MMF therapy.61 A systematic review of 18 studies including 140 children and adults with AD showed a significant reduction in SCORAD scores with MMF treatment. The average time for initial effects to be observed was 6.8 weeks, and relapses occurred in 8.2% of cases.62

Common adverse reactions of MMF include leukopenia, infection, GI disturbances and decreased resistance to infection. Serious adverse reactions include neutropenia and pure red cell aplasia. There is an increased risk of developing lymphomas and other malignancies, particularly of the skin, and photoprotection should be advised.58 In the systematic review of patients with AD treated with MMF, the majority of adverse effects were transient or mild. The most common side effects were headaches and GI discomfort. Anemia, leukopenia, neutropenia and thrombocytopenia were rare. Herpes infection occurred in 9.3% of patients, which was significantly associated with a prolonged treatment duration.62 Although viral and bacterial infections have been described in patients undergoing treatment with MMF, a patient with a history of recurrent eczema herpeticum actually experienced a decrease in frequency and severity of viral outbreaks in a retrospective case series of 14 children aged 2 to 16 years with refractory AD treated with MMF.63 In another retrospective case series of 28 children with severe AD aged 3 to 17 years previously mentioned in the AZA section, 12 of the 28 patients transitioned from AZA to MMF due to medication intolerance and/or failure to respond to AZA. Two-thirds of the patients reported significant improvement with MMF, and experienced seemingly less-severe side effects compared to AZA.45

MMF has been shown to be effective in the management of adults and children with severe AD, however, the evidence is rather limited. It has an acceptable short-term adverse effect profile and may be better tolerated compared to AZA.

Dupilumab

Dupilumab is a human monoclonal antibody that directly binds the IL-4 receptor α-subunit, which blocks downstream signaling of IL-4 and IL-13.64 It is indicated for the treatment of moderate to severe AD in patients aged 6 years and older whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable. It is also indicated as a maintenance treatment for certain patients with moderate to severe asthma and for patients with inadequately controlled chronic rhinosinusitis with nasal polyposis.26 In early-phase, double-blind, placebo-controlled RCTs of adults with moderate to severe AD, patients treated with dupilumab improved in all evaluated measures of AD disease activity.65 Two randomized, placebo-controlled, phase 3 trials of 1379 adults with moderate to severe AD showed that 16 weeks of dupilumab treatment was superior to placebo in improving the signs and symptoms of AD, including pruritus, symptoms of anxiety and depression, and quality of life.66 A randomized, double-blind, placebo-controlled, phase 3 trial of 740 adults with moderate to severe AD revealed that adding dupilumab to topical corticosteroids (TCS) improved efficacy across multiple measures of clinical severity compared to placebo plus TCS over 52 weeks.67 In a randomized, double-blind, placebo-controlled, phase 3 trial of 251 children aged 12 to 17 years with moderate to severe AD, dupilumab significantly improved AD signs, symptoms, and quality of life compared to placebo after 12 weeks.68 In an ongoing phase 3 open-label extension study of pediatric patients, which continues to enroll by invitation, 36 children aged 12 to 17 years treated with dupilumab for 52 weeks experienced sustained improvements in disease severity.69,70 A randomized, double-blind, placebo-controlled, phase 3 trial of 367 children aged 6 to 11 years with severe AD demonstrated that patients treated with dupilumab plus TCS for 16 weeks had a significant improvement in Investigator’s Global Assessment (IGA) compared to those treated with placebo plus TCS.71

Common adverse reactions of dupilumab include injection site reactions, conjunctivitis, blepharitis, oral herpes, keratitis, eye pruritus, other herpes complex virus infections, and dry eye.26 An analysis of three randomized, double-blind, placebo-controlled phase 3 trials of 2116 adults with moderate to severe AD revealed that conjunctivitis and injection site reactions were more frequent in patients treated with dupilumab compared to placebo. A small number of transient reductions in neutrophils and platelets were observed, as well as transient increases in eosinophils. These changes in laboratory parameters were not associated with any clinical adverse events. This supports the current guidance that there is no requirement for routine laboratory monitoring before initiation or during treatment with dupilumab.72 The open-label extension study of pediatric patients found that 52 weeks of dupilumab treatment had a comparable safety profile to 16 weeks of treatment, supporting the long-term use of dupilumab in adolescents.69 The trial of children aged 6 to 11 years showed that dupilumab was well tolerated and the most frequently reported side effects were upper respiratory tract infections, nasopharyngitis, headache, vomiting, injection site erythema and conjunctivitis.71 Notably, in most AD trials, patients treated with dupilumab had a higher incidence of conjunctivitis compared to placebo, which was associated with higher baseline AD severity and a prior history of conjunctivitis. Most cases were mild to moderate and resolved while continuing dupilumab treatment.73

Currently, dupilumab is the only FDA-approved biologic treatment for childhood and adult AD. It has been shown to be efficacious in numerous clinical trials, and despite reports of injection site reactions and conjunctivitis, it has an overall favorable safety profile. Dupilumab is considered the first-line systemic therapy of choice in the management of AD given its effectiveness upon clinical manifestations, excellent benefit/risk profile, and positive impact upon patients’ and families’ quality of life. While dupilumab is not indicated to treat infantile AD, a phase 2/3 study investigating the pharmacokinetics, safety, and efficacy of dupilumab in patients aged 6 months to 5 years with moderate to severe AD is currently recruiting.74

Emerging Systemic Therapies

Emerging systemic therapies for AD include biologics and oral JAK inhibitors. Tralokinumab and lebrikizumab are monoclonal antibodies that target IL-13, nemolizumab targets IL-31, and fezakinumab targets IL-22.64 Phase 2 and 3 trials have demonstrated that tralokinumab is an effective and well tolerated treatment option for adults with moderate to severe AD.75–77 An ongoing phase 3 trial is evaluating the efficacy of tralokinumab compared to placebo in treating adolescents aged 12 to 17 years with moderate to severe AD.78 A long-term extension phase 3 trial enrolling by invitation is evaluating the safety of tralokinumab in patients aged 12 years and older with AD.79 Phase 2 trials have shown that lebrikizumab is efficacious with a favorable safety profile in adults with moderate to severe AD.80,81 Phase 3 trials are recruiting to assess the efficacy and safety of lebrikizumab in patients aged 12 years and older with moderate to severe AD.82–86 Phase 2 studies have demonstrated that nemolizumab results in rapid and sustained improvements and is well tolerated in adults with moderate to severe AD.87–89 A phase 3 trial of patients aged 13 years and older with AD and moderate to severe pruritus showed that nemolizumab reduced pruritus.90 A phase 2 study assessing the pharmacokinetics and safety of nemolizumab in adolescents aged 12 to 17 years with moderate to severe AD has been completed, however, the results have not yet been posted.91 Phase 3 studies are recruiting to evaluate the safety and efficacy of nemolizumab in patients aged 12 years and older with moderate to severe AD.92–94 A phase 2 trial showed that fezakinumab had a favorable safety profile in adults with moderate to severe AD, with significant clinical improvements primarily observed in severe AD patients.95

Oral JAK inhibitors currently being investigated include baricitinib, upadacitinib, and abrocitinib, which target cytokines involved in the pathogenesis of AD.96 In phase 2 and 3 trials, baricitinib significantly improved the signs and symptoms of adults with moderate to severe AD with an acceptable safety profile.97–101 Phase 3 studies are recruiting and ongoing to evaluate the safety and efficacy of baricitinib in patients aged 2 years and older with AD.102,103 A phase 2 trial demonstrated that upadacitinib was efficacious with a favorable benefit/risk profile in adults with moderate to severe AD.104 Phase 3 trials are recruiting and ongoing to assess the efficacy and safety of upadacitinib in patients aged 12 years and older with moderate to severe AD.105–109 A phase 1 study is recruiting to evaluate the safety, pharmacokinetics and tolerability of upadacitinib in pediatric patients aged 6 months to 12 years with severe AD.110 Phase 2 and 3 trials showed that abrocitinib was effective and well tolerated in patients aged 12 years and older with moderate to severe AD.111–114 A phase 3 study is enrolling by invitation to evaluate the efficacy and safety of abrocitinib in patients aged 12 years and older with moderate to severe AD over variable treatment periods.115 Overall, the results of clinical trials exploring the efficacy and safety of these emerging therapies have been promising. Continued investigations are necessary to evaluate long-term efficacy and safety, especially in children, and such studies are ongoing.

Conclusion

Systemic therapy may be warranted in childhood and adult AD that is not adequately controlled with topical medications. Conventional systemic immunomodulating agents are commonly used off-label, with CsA demonstrating the greatest short-term efficacy. However, for patients requiring more long-term treatment the side effects of CsA are concerning, thus, alternative therapies such as AZA, MTX, and MMF should be considered. Dupilumab is currently the only biologic approved as a first-line treatment for moderate to severe AD in patients aged 6 years and older, and has changed the landscape of AD treatment. Additional biologic and small-molecule medications targeting specific inflammatory pathways have shown promising results in clinical trials and these studies are ongoing. Ultimately, the choice of systemic therapy depends on each individual patient’s needs, and patient education is essential to improve treatment adherence.