Yik Weng Yew1, Jacob P Thyssen2, Jonathan I Silverberg3. 1. Institute of Dermatology, National Skin Centre, Singapore. 2. Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. 3. Department of Dermatology, Preventive Medicine and Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Northwestern Medicine Multidisciplinary Eczema Center, Chicago, Illinois. Electronic address: JonathanISilverberg@gmail.com.
Abstract
BACKGROUND: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms. OBJECTIVE: To determine the prevalences of AD characteristics and differences by region and age. METHODS: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed a review study titles and/or abstracts and data abstraction. RESULTS: In all, 101 studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification, and xerosis. There were differences in AD characteristics by study region. Flexural involvement was less commonly reported in India, the Americas, and Iran. Studies from East Asian reported more erythroderma and truncal, extensor, scalp, and auricular involvement. Studies from Southeast Asia reported more exudative eczema, truncal involvement, lichenification, and prurigo nodularis. Studies from Iran reported more head, face, and neck involvement; pityriasis alba; and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis, and orbital darkening. LIMITATIONS: Heterogeneity between studies and limited reporting of certain AD clinical characteristics. CONCLUSIONS: AD characteristics are heterogeneous and vary by region and age.
BACKGROUND: Previous studies found conflicting results about the commonality of different atopic dermatitis (AD) signs and symptoms. OBJECTIVE: To determine the prevalences of AD characteristics and differences by region and age. METHODS: A systematic review was performed of all published studies in MEDLINE, EMBASE, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii that analyzed the proportion of AD characteristics. Two reviewers performed a review study titles and/or abstracts and data abstraction. RESULTS: In all, 101 studies reported proportion of AD features with sufficient data for meta-analysis. The most prevalent AD features were pruritus, lichenification, and xerosis. There were differences in AD characteristics by study region. Flexural involvement was less commonly reported in India, the Americas, and Iran. Studies from East Asian reported more erythroderma and truncal, extensor, scalp, and auricular involvement. Studies from Southeast Asia reported more exudative eczema, truncal involvement, lichenification, and prurigo nodularis. Studies from Iran reported more head, face, and neck involvement; pityriasis alba; and xerosis. Studies from Africa reported more papular lichenoid lesions, palmar hyperlinearity, ichthyosis, and orbital darkening. LIMITATIONS: Heterogeneity between studies and limited reporting of certain AD clinical characteristics. CONCLUSIONS: AD characteristics are heterogeneous and vary by region and age.
Authors: Tammy Hua; Muhammad Yousaf; Eran Gwillim; Yik Weng Yew; Brad Lee; Kevin Hua; Taylor Erickson; Brian Cheng; Jonathan I Silverberg Journal: Arch Dermatol Res Date: 2020-11-16 Impact factor: 3.017
Authors: Andrew Blauvelt; Melinda Gooderham; Neal Bhatia; Richard G Langley; Shannon Schneider; John Zoidis; Azra Kurbasic; April Armstrong; Jonathan I Silverberg Journal: Dermatol Ther (Heidelb) Date: 2022-09-24
Authors: Marissa T Ayasse; Adnan Ahmed; Maria L Espinosa; Christina J Walker; Muhammad Yousaf; Jacob P Thyssen; Jonathan I Silverberg Journal: Arch Dermatol Res Date: 2020-11-22 Impact factor: 3.017
Authors: P Chieosilapatham; C Kiatsurayanon; Y Umehara; J V Trujillo-Paez; G Peng; H Yue; L T H Nguyen; F Niyonsaba Journal: Clin Exp Immunol Date: 2021-02-15 Impact factor: 5.732
Authors: J I Silverberg; D Lei; M Yousaf; S R Janmohamed; P P Vakharia; R Chopra; R Chavda; S Gabriel; K R Patel; V Singam; R Kantor; D Y Hsu Journal: Br J Dermatol Date: 2020-09-21 Impact factor: 9.302
Authors: J I Silverberg; D Lei; M Yousaf; S R Janmohamed; P P Vakharia; R Chopra; R Chavda; S Gabriel; K R Patel; V Singam; R Kantor; D Y Hsu Journal: J Eur Acad Dermatol Venereol Date: 2020-09-01 Impact factor: 6.166