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Literature DB >> 3410055

Synthetic magainin analogues with improved antimicrobial activity.

H C Chen¹, J H Brown, J L Morell, C M Huang.

Abstract

Based on modifications to enhance the alpha-helical structure of the broad spectrum antibiotic magainin 2, a series of analogues have been synthesized which display an increase up to two orders of magnitude in antimicrobial activity and, in the most favorable case, no appreciable increase in hemolytic activity over magainin 1 at the concentrations tested.

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Year: 1988 PMID： 3410055 DOI： 10.1016/0014-5793(88)80077-2

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

51 in total

1. N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity.

Authors: H Wakabayashi; H Matsumoto; K Hashimoto; S Teraguchi; M Takase; H Hayasawa
Journal: Antimicrob Agents Chemother Date: 1999-05 Impact factor: 5.191

2. Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II.

Authors: C B Park; K S Yi; K Matsuzaki; M S Kim; S C Kim
Journal: Proc Natl Acad Sci U S A Date: 2000-07-18 Impact factor: 11.205

3. Effect of phospholipid composition on an amphipathic peptide-mediated pore formation in bilayer vesicles.

Authors: F Nicol; S Nir; F C Szoka
Journal: Biophys J Date: 2000-02 Impact factor: 4.033

4. Change of glutamic acid to lysine in a 13-residue antibacterial and hemolytic peptide results in enhanced antibacterial activity without increase in hemolytic activity.

Authors: N Sitaram; M Chandy; V N Pillai; R Nagaraj
Journal: Antimicrob Agents Chemother Date: 1992-11 Impact factor: 5.191

5. Augmentation of the antibacterial activity of magainin by positive-charge chain extension.

Authors: R Bessalle; H Haas; A Goria; I Shalit; M Fridkin
Journal: Antimicrob Agents Chemother Date: 1992-02 Impact factor: 5.191

6. Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes.

Authors: Frank Heinrich; Aria Salyapongse; Akari Kumagai; Fernando G Dupuy; Karpur Shukla; Anja Penk; Daniel Huster; Robert K Ernst; Anna Pavlova; James C Gumbart; Berthony Deslouches; Y Peter Di; Stephanie Tristram-Nagle
Journal: Chemistry Date: 2020-04-28 Impact factor: 5.236

Synthetic magainin analogues with improved antimicrobial activity.

1. N-Acylated and D enantiomer derivatives of a nonamer core peptide of lactoferricin B showing improved antimicrobial activity.

2. Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: the proline hinge is responsible for the cell-penetrating ability of buforin II.

3. Effect of phospholipid composition on an amphipathic peptide-mediated pore formation in bilayer vesicles.

4. Change of glutamic acid to lysine in a 13-residue antibacterial and hemolytic peptide results in enhanced antibacterial activity without increase in hemolytic activity.

5. Augmentation of the antibacterial activity of magainin by positive-charge chain extension.

6. Synergistic Biophysical Techniques Reveal Structural Mechanisms of Engineered Cationic Antimicrobial Peptides in Lipid Model Membranes.

Review 7. Antifungal peptides: novel therapeutic compounds against emerging pathogens.

8. Magainins and the disruption of membrane-linked free-energy transduction.

9. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes?

10. Effects of two magainin peptides on eicosanoid release from rat peritoneal macrophages.