Literature DB >> 2671997

Magainins and the disruption of membrane-linked free-energy transduction.

H V Westerhoff1, D Juretić, R W Hendler, M Zasloff.   

Abstract

Magainins, a family of positively charged peptides, are partly if not wholly responsible for antimicrobial activity in skin extracts of Xenopus laevis. We report here that members of the magainin family--i.e., the 21-amino acid peptide PGLa and the 23-amino acid peptide magainin 2 amide (PGSa)--dissipate the electric potential across various energy-transducing membranes and thus uncouple respiration from other free-energy-requiring processes. We propose that this is a likely mechanism for the antimicrobial effects of these compounds.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2671997      PMCID： PMC297891          DOI： 10.1073/pnas.86.17.6597

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  38 in total

Review 1.  Preparation and characterization of mitochondria and submitochondrial particles of rat liver and liver-derived tissues.

Authors:  P L Pedersen; J W Greenawalt; B Reynafarje; J Hullihen; G L Decker; J W Soper; E Bustamente
Journal:  Methods Cell Biol       Date:  1978       Impact factor: 1.441

2.  Studies on bacterial photophosphorylation. III. A sensitive and rapid method of determination of photophosphorylation.

Authors:  M NISHIMURA; T ITO; B CHANCE
Journal:  Biochim Biophys Acta       Date:  1962-05-07

3.  The proton electrochemical gradient in Escherichia coli cells.

Authors:  E Padan; D Zilberstein; H Rottenberg
Journal:  Eur J Biochem       Date:  1976-04-01

4.  The electrochemical gradient of protons and its relationship to active transport in Escherichia coli membrane vesicles.

Authors:  S Ramos; S Schuldiner; H R Kaback
Journal:  Proc Natl Acad Sci U S A       Date:  1976-06       Impact factor: 11.205

5.  Interaction between uncouplers and substrates in rat-liver mitochondria.

Authors:  R Kraayenhof; K van Dam
Journal:  Biochim Biophys Acta       Date:  1969-02-25

6.  Respiratory control and the proton electrochemical gradient in mitochondria.

Authors:  E Padan; H Rottenberg
Journal:  Eur J Biochem       Date:  1973-12-17

7.  Changes in Escherichia coli cell envelope structure and the sites of fluorescence probe binding caused by carbonyl cyanide p-trifluoromethoxyphenylhydrazone.

Authors:  S L Helgerson; W A Cramer
Journal:  Biochemistry       Date:  1977-09-06       Impact factor: 3.162

8.  Membrane potential of mitochondria measured with an electrode sensitive to tetraphenyl phosphonium and relationship between proton electrochemical potential and phosphorylation potential in steady state.

Authors:  N Kamo; M Muratsugu; R Hongoh; Y Kobatake
Journal:  J Membr Biol       Date:  1979-08       Impact factor: 1.843

9.  Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'.

Authors:  D Pietrobon; G F Azzone; D Walz
Journal:  Eur J Biochem       Date:  1981-07

10.  Antibacterial peptide from normal rabbit serum. 3. Inhibition of microbial electron transport.

Authors:  S F Carroll; R J Martinez
Journal:  Biochemistry       Date:  1981-10-13       Impact factor: 3.162
View more
  66 in total

1.  Orientation, dynamics, and lipid interaction of an antimicrobial arylamide investigated by 19F and 31P solid-state NMR spectroscopy.

Authors:  Yongchao Su; William F DeGrado; Mei Hong
Journal:  J Am Chem Soc       Date:  2010-07-07       Impact factor: 15.419

2.  Membrane binding, structure, and localization of cecropin-mellitin hybrid peptides: a site-directed spin-labeling study.

Authors:  Kalpana Bhargava; Jimmy B Feix
Journal:  Biophys J       Date:  2004-01       Impact factor: 4.033

3.  Structure of (KIAGKIA)3 aggregates in phospholipid bilayers by solid-state NMR.

Authors:  Orsolya Toke; R D O'Connor; Thomas K Weldeghiorghis; W Lee Maloy; Ralf W Glaser; Anne S Ulrich; Jacob Schaefer
Journal:  Biophys J       Date:  2004-07       Impact factor: 4.033

4.  Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

Authors:  G Diamond; M Zasloff; H Eck; M Brasseur; W L Maloy; C L Bevins
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

5.  Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity.

Authors:  Dayeong Kim; Nagasundarapandian Soundrarajan; Juyeon Lee; Hye-Sun Cho; Minkyeung Choi; Se-Yeoun Cha; Byeongyong Ahn; Hyoim Jeon; Minh Thong Le; Hyuk Song; Jin-Hoi Kim; Chankyu Park
Journal:  Antimicrob Agents Chemother       Date:  2017-08-24       Impact factor: 5.191

Review 6.  Computational studies of peptide-induced membrane pore formation.

Authors:  Richard Lipkin; Themis Lazaridis
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2017-08-05       Impact factor: 6.237

7.  Structure and interactions of magainin antibiotic peptides in lipid bilayers: a solid-state nuclear magnetic resonance investigation.

Authors:  B Bechinger; M Zasloff; S J Opella
Journal:  Biophys J       Date:  1992-04       Impact factor: 4.033

8.  In vitro activities of lytic peptides against the sporozoites of Cryptosporidium parvum.

Authors:  M J Arrowood; J M Jaynes; M C Healey
Journal:  Antimicrob Agents Chemother       Date:  1991-02       Impact factor: 5.191

9.  Deciphering the mode of action of the synthetic antimicrobial peptide Bac8c.

Authors:  E C Spindler; J D F Hale; T H Giddings; R E W Hancock; R T Gill
Journal:  Antimicrob Agents Chemother       Date:  2011-01-31       Impact factor: 5.191

10.  The down-regulation of cathepsin G in THP-1 monocytes after infection with Mycobacterium tuberculosis is associated with increased intracellular survival of bacilli.

Authors:  Carlos A Rivera-Marrero; Julie Stewart; William M Shafer; Jesse Roman
Journal:  Infect Immun       Date:  2004-10       Impact factor: 3.441
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.