| Literature DB >> 3409978 |
G Stenman1, F Rorsman, C Betsholtz.
Abstract
The human platelet-derived growth factor A-chain (PDGFA) locus was mapped by in situ hybridization. By use of human cDNA probes encoding the PDGF A-chain precursor polypeptide the gene was assigned to the proximal long arm of chromosome 7, band q11.23. Of 76 cells with silver grains on chromosome 7, 28% had label over this band. Our assignment represents a confirmation and further sublocalization of the PDGFA locus. The location correlates with specific chromosomal abnormalities associated with certain human developmental malformations and neoplasms.Entities:
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Year: 1988 PMID： 3409978 DOI： 10.1016/0014-4827(88)90389-8
Source DB: PubMed Journal: Exp Cell Res ISSN： 0014-4827 Impact factor: 3.905