Literature DB >> 3409963

The oxytocin antagonist d(CH2)5Tyr(Me)-Orn8-vasotocin inhibits male copulatory behaviour in rats.

A Argiolas1, M Collu, G L Gessa, M R Melis, G Serra.   

Abstract

The effect of an intracerebroventricular (i.c.v.) injection of the oxytocin antagonist, d(CH2)5Tyr(Me)-Orn8-vasotocin, on the copulatory behaviour of vigorous male rats in the presence of females in estrus was studied. The peptide (2.5, 25 and 50 ng, 15 min before mating tests) decreased the number of mounts and intromissions, and abolished ejaculation almost completely at all doses tested. The peptide failed to significantly influence motor activity at the doses used. The results support the hypothesis that central oxytocin plays a physiological role in the expression of copulatory behaviour.

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Year:  1988        PMID： 3409963     DOI： 10.1016/0014-2999(88)90675-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  16 in total

1.  Oxytocin in the medial preoptic area facilitates male sexual behavior in the rat.

Authors:  Mario Gil; Renu Bhatt; Katie B Picotte; Elaine M Hull
Journal:  Horm Behav       Date:  2010-12-31       Impact factor: 3.587

2.  The effect of single-dose oxytocin application on time to ejaculation and seminal parameters in men.

Authors:  K Walch; R Eder; A Schindler; W Feichtinger
Journal:  J Assist Reprod Genet       Date:  2001-12       Impact factor: 3.412

3.  Oxytocin-induced penile erection and yawning in male rats: effect of neonatal monosodium glutamate and hypophysectomy.

Authors:  A Argiolas; M R Melis; A Mauri; G L Gessa
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

4.  Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.

Authors:  K Nishimori; L J Young; Q Guo; Z Wang; T R Insel; M M Matzuk
Journal:  Proc Natl Acad Sci U S A       Date:  1996-10-15       Impact factor: 11.205

5.  Oxytocin receptors modulate a social salience neural network in male prairie voles.

Authors:  Zachary V Johnson; Hasse Walum; Yao Xiao; Paula C Riefkohl; Larry J Young
Journal:  Horm Behav       Date:  2016-10-26       Impact factor: 3.587

6.  The output of the hippocampus is inhibited during social behavior in the male rat.

Authors:  J Garritano; C Martinez; K Grossman; P Intemann; K Merritt; R Pfoff; T Smock
Journal:  Exp Brain Res       Date:  1996-09       Impact factor: 1.972

Review 7.  Actions of pituitary hormones beyond traditional targets.

Authors:  Mone Zaidi; Maria I New; Harry C Blair; Alberta Zallone; Ramkumarie Baliram; Terry F Davies; Christopher Cardozo; James Iqbal; Li Sun; Clifford J Rosen; Tony Yuen
Journal:  J Endocrinol       Date:  2018-03-19       Impact factor: 4.286

8.  Inhibition of ejaculation by the non-peptide oxytocin receptor antagonist GSK557296: a multi-level site of action.

Authors:  Pierre Clément; Jacques Bernabé; Sandrine Compagnie; Laurent Alexandre; Stewart McCallum; François Giuliano
Journal:  Br J Pharmacol       Date:  2013-08       Impact factor: 8.739

9.  Sexual experience increases oxytocin receptor gene expression and protein in the medial preoptic area of the male rat.

Authors:  Mario Gil; Renu Bhatt; Katie B Picotte; Elaine M Hull
Journal:  Psychoneuroendocrinology       Date:  2013-03-07       Impact factor: 4.905

Review 10.  Oxytocin in the Male Reproductive Tract; The Therapeutic Potential of Oxytocin-Agonists and-Antagonists.

Authors:  Beatrix Stadler; Michael R Whittaker; Betty Exintaris; Ralf Middendorff
Journal:  Front Endocrinol (Lausanne)       Date:  2020-10-22       Impact factor: 5.555
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