PURPOSE: To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters. METHODS: The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVF patients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prioroxytocin treatment. RESULTS: No significant difference was noted between the two groups concerning ejaculation time and semen parameters. CONCLUSIONS: Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.
RCT Entities:
PURPOSE: To report the effect of a single dose of oxytocin on ejaculation time and seminal parameters. METHODS: The prospective randomized clinical study was performed at a private assisted reproduction technology center and included 103 consecutive healthy men (semen donors or husbands of IVFpatients). Oxytocin (16 IU) were administered intranasally to 49 subjects, randomly assigned to the study group just before masturbation to ejaculation. The time needed for ejaculation as well as the semen parameters was recorded according to the WHO standards, and compared to the control group of 54 subjects with no prior oxytocin treatment. RESULTS: No significant difference was noted between the two groups concerning ejaculation time and semen parameters. CONCLUSIONS: Although the administration of oxytocin stimulates sexual behavior and performance in mammalian species, our data indicate that oxytocin has no detectable effect on ejaculation time and seminal parameters after intranasal application in normal, healthy men.
Authors: J H van Roijen; A K Slob; W L Gianotten; G R Dohle; A T van der Zon; J T Vreeburg; R F Weber Journal: Hum Reprod Date: 1996-01 Impact factor: 6.918