Literature DB >> 34097491

Efficacy of Antistaphylococcal Lysin LSVT-1701 in Combination with Daptomycin in Experimental Left-Sided Infective Endocarditis Due to Methicillin-Resistant Staphylococcus aureus.

David B Huang1, Eric Gaukel1, Nancy Kerzee1, Katyna Borroto-Esoda1, Simon Lowry1, Yan Q Xiong2,3, Wessam Abdelhady2, Arnold S Bayer2,3.   

Abstract

We utilized the rabbit model of aortic valve infective endocarditis to examine the combined efficacy of the lysin LSVT-1701 plus daptomycin. The combination of LSVT-1701 plus daptomycin was highly effective at reducing methicillin-resistant Staphylococcus aureus (MRSA) counts in target tissue. When given for four daily doses, both lysin dose regimens in combination with daptomycin sterilized all target tissues. These findings suggest that LSVT-1701 warrants further clinical evaluation as an adjunctive therapy for the treatment of invasive MRSA infections.

Entities:  

Keywords:  LSVT-1701; MRSA; bacteremia; daptomycin; infective endocarditis

Mesh：

Substances：

Year:  2021        PMID： 34097491      PMCID： PMC8284455          DOI： 10.1128/AAC.00508-21

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  12 in total

1.  Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period.

Authors:  Soo Youn Jun; Gi Mo Jung; Seong Jun Yoon; So Young Youm; Hyoung-Yun Han; Jong-Hwa Lee; Sang Hyeon Kang
Journal:  Clin Exp Pharmacol Physiol       Date:  2016-10       Impact factor: 2.557

Review 2.  Infective endocarditis.

Authors:  Thomas L Holland; Larry M Baddour; Arnold S Bayer; Bruno Hoen; Jose M Miro; Vance G Fowler
Journal:  Nat Rev Dis Primers       Date:  2016-09-01       Impact factor: 52.329

3.  Preclinical safety evaluation of intravenously administered SAL200 containing the recombinant phage endolysin SAL-1 as a pharmaceutical ingredient.

Authors:  Soo Youn Jun; Gi Mo Jung; Seong Jun Yoon; Yun-Jaie Choi; Woo Suk Koh; Kyoung Sik Moon; Sang Hyeon Kang
Journal:  Antimicrob Agents Chemother       Date:  2014-01-21       Impact factor: 5.191

4.  Effect of the Lysin Exebacase on Cardiac Vegetation Progression in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Endocarditis as Determined by Echocardiography.

Authors:  Dario Lehoux; Arnold S Bayer; Sonia U Shah; Yan Q Xiong; Wessam Abdelhady; James Iwaz; Youngju Pak; Raymond Schuch; Cara Cassino
Journal:  Antimicrob Agents Chemother       Date:  2020-06-23       Impact factor: 5.191

5.  Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1.

Authors:  Soo Youn Jun; Gi Mo Jung; Seong Jun Yoon; Myoung-Don Oh; Yun-Jaie Choi; Woo Jong Lee; Joon-Chan Kong; Jae Goo Seol; Sang Hyeon Kang
Journal:  Int J Antimicrob Agents       Date:  2012-12-28       Impact factor: 5.283

Review 6.  Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.

Authors:  Steven Y C Tong; Joshua S Davis; Emily Eichenberger; Thomas L Holland; Vance G Fowler
Journal:  Clin Microbiol Rev       Date:  2015-07       Impact factor: 26.132

7.  Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection.

Authors:  Wan Beom Park; Hong Bin Kim; Nak-Hyun Kim; Jeong Eun Cho; Yoon Jeong Choi; Su Jin Choi; Soo Youn Jun; Chang Kyung Kang; Kyoung-Ho Song; Pyoeng Gyun Choe; Ji-Hwan Bang; Eu Suk Kim; Sang Won Park; Nam-Joong Kim; Myoung-Don Oh
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

8.  Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics.

Authors:  María Pilar Trotonda; Yan Q Xiong; Guido Memmi; Arnold S Bayer; Ambrose L Cheung
Journal:  J Infect Dis       Date:  2009-01-15       Impact factor: 5.226

9.  Analysis of cell membrane characteristics of in vitro-selected daptomycin-resistant strains of methicillin-resistant Staphylococcus aureus.

Authors:  Nagendra N Mishra; Soo-Jin Yang; Ayumi Sawa; Aileen Rubio; Cynthia C Nast; Michael R Yeaman; Arnold S Bayer
Journal:  Antimicrob Agents Chemother       Date:  2009-03-30       Impact factor: 5.191

10.  Efficacy of vancomycin plus rifampin in experimental aortic-valve endocarditis due to methicillin-resistant Staphylococcus aureus: in vitro-in vivo correlations.

Authors:  A S Bayer; K Lam
Journal:  J Infect Dis       Date:  1985-01       Impact factor: 5.226
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  3 in total

1.  A Phase 1 Study To Evaluate Safety and Pharmacokinetics following Administration of Single and Multiple Doses of the Antistaphylococcal Lysin LSVT-1701 in Healthy Adult Subjects.

Authors:  Mary Beth Wire; Soo Youn Jun; In-Jin Jang; Seung-Hwan Lee; Jun Gi Hwang; David B Huang
Journal:  Antimicrob Agents Chemother       Date:  2022-01-10       Impact factor: 5.938

Review 2.  Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed.

Authors:  Mark S Butler; Valeria Gigante; Hatim Sati; Sarah Paulin; Laila Al-Sulaiman; John H Rex; Prabhavathi Fernandes; Cesar A Arias; Mical Paul; Guy E Thwaites; Lloyd Czaplewski; Richard A Alm; Christian Lienhardt; Melvin Spigelman; Lynn L Silver; Norio Ohmagari; Roman Kozlov; Stephan Harbarth; Peter Beyer
Journal:  Antimicrob Agents Chemother       Date:  2022-01-10       Impact factor: 5.191

Review 3.  Native valve, prosthetic valve, and cardiac device-related infective endocarditis: A review and update on current innovative diagnostic and therapeutic strategies.

Authors:  Joop J P Kouijzer; Daniëlle J Noordermeer; Wouter J van Leeuwen; Nelianne J Verkaik; Kirby R Lattwein
Journal:  Front Cell Dev Biol       Date:  2022-10-03
  3 in total

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