Giuseppe Meccariello1, Antonino Maniaci2, Giulia Bianchi3, Giovanni Cammaroto4, Giannicola Iannella4, Andrea Catalano3, Rossella Sgarzani5, Andrea De Vito4, Pasquale Capaccio6, Stefano Pelucchi2, Claudio Vicini4. 1. Otolaryngology and Head-Neck Surgery Unit, Department of Head-Neck Surgeries, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy. Electronic address: drmeccariello@gmail.com. 2. Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, University of Catania, Catania, Italy. 3. Otolaryngology Unit, University of Ferrara, Ferrara, Italy. 4. Otolaryngology and Head-Neck Surgery Unit, Department of Head-Neck Surgeries, Morgagni Pierantoni Hospital, Azienda USL della Romagna, Forlì, Italy. 5. Burn Unit, Maurizio Bufalini Hospital, Azienda USL della Romagna, Cesena, Italy. 6. Department of Biomedical, Surgical and Dental Sciences - University of Milan, Milan, Italy.
Abstract
OBJECTIVE: Trans Oral Robotic Surgery (TORS) is a modality in the management of oropharyngeal squamous cell carcinoma(OPSCC). This study was planned to determine whether Selective Neck Dissection (SND) is oncological safe procedure even in patients with lymph node metastases. METHODS: OPSCC patients were divided into Modified Radical Neck Dissection (MRND) and SND groups. The outcome measures were overall survival (OS), disease-free survival (DFS) and regional recurrence free survival (RRFS). RESULTS: Thirty-seven SNDs and 18 MRNDs were performed. Regional relapse rate was 6.1% in SND group whilst 18.8% in MRND group(p=0.19). The 5-year OS, DFS and RRFS rates' differences were not statistically significant between SND and MRND groups (p=0.40, p=0.42 and p=0.18, respectively). At multivariate analysis, advanced stage impacted the 5-year OS and DFS(HR=9.39, p<0.01 and HR=11.03, p=0.04). CONCLUSIONS: The SND seems to be effective in a TORS framework. The indication should be accurately discussed by the multidisciplinary tumor board.
OBJECTIVE: Trans Oral Robotic Surgery (TORS) is a modality in the management of oropharyngeal squamous cell carcinoma(OPSCC). This study was planned to determine whether Selective Neck Dissection (SND) is oncological safe procedure even in patients with lymph node metastases. METHODS: OPSCC patients were divided into Modified Radical Neck Dissection (MRND) and SND groups. The outcome measures were overall survival (OS), disease-free survival (DFS) and regional recurrence free survival (RRFS). RESULTS: Thirty-seven SNDs and 18 MRNDs were performed. Regional relapse rate was 6.1% in SND group whilst 18.8% in MRND group(p=0.19). The 5-year OS, DFS and RRFS rates' differences were not statistically significant between SND and MRND groups (p=0.40, p=0.42 and p=0.18, respectively). At multivariate analysis, advanced stage impacted the 5-year OS and DFS(HR=9.39, p<0.01 and HR=11.03, p=0.04). CONCLUSIONS: The SND seems to be effective in a TORS framework. The indication should be accurately discussed by the multidisciplinary tumor board.
Authors: Carlos Miguel Chiesa-Estomba; Juan David Urazan; Cammaroto Giovanni; Mannelli Giuditta; Molteni Gabriele; Dallari Virginia; R Lechien Jerome; Miguel Mayo-Yanez; José Ángel González-García; Jon Alexander Sistiaga-Suarez; Tucciarone Manuel; Ayad Tareck; Meccariello Giuseppe Journal: Eur Arch Otorhinolaryngol Date: 2022-09-14 Impact factor: 3.236
Authors: Mussab Kouka; Jens Buentzel; Holger Kaftan; Daniel Boeger; Andreas H Mueller; Andrea Wittig; Stefan Schultze-Mosgau; Thomas Ernst; Orlando Guntinas-Lichius Journal: Cancers (Basel) Date: 2022-06-24 Impact factor: 6.575