Shu Cao1, Matteo Borro2, Sarah Alonzi3, Sayantani Sindher4, Kari Nadeau4, R Sharon Chinthrajah5. 1. Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif. 2. Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif; Clinical Immunology Unit, Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino, Genoa, Italy; Department of Internal Medicine, San Paolo Hospital, Savona, Italy. 3. Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif; Department of Psychology, Loyola University, New Orleans, La. 4. Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, Calif. 5. Sean N. Parker Center for Allergy and Asthma Research at Stanford University, Stanford University, Stanford, Calif; Division of Pulmonary and Critical Care Medicine, Stanford University, Stanford, Calif. Electronic address: schinths@stanford.edu.
Abstract
BACKGROUND: Food allergy (FA) is a growing global problem that can affect patients' health-related quality of life (HRQoL) owing to increased anxiety as well as social and economic restrictions. Interventions such as oral food challenges (OFCs) and oral immunotherapy (OIT) have been shown to improve HRQoL. However, meta-analyses and systematic synthesis of these data are lacking. OBJECTIVE: To review and quantitatively synthesize potential benefits of interventions (OIT and OFC) systematically to address FA to a variety of foods. METHODS: We conducted a systematic search through PubMed and Cochrane Medical Library databases and performed a meta-analysis focusing on studies assessing changes in HRQoL after OIT and/or OFCs in FA participants and caregivers from 2010 to July 2020. Random effects model and I2 statistics were used to assess overall intervention effects and heterogeneity across studies. RESULTS: We included 13 publications in this meta-analysis (OIT = 7; OFCs = 6). Mean change in HRQoL scores after OIT and OFCs was -1.25 (P < .001) and -0.78 (P = .052), with a significant I2 of 87% (P < .001) and 90% (P < .001), respectively. Five OIT studies found significant improvements in HRQoL in the OIT group compared with the placebo group, with an overall standardized mean difference of -0.56 (P = .007; I2 = 42%, P = .099). CONCLUSIONS: This meta-analysis showed that in FA patients, both OIT and OFCs are associated with an improvement in HRQoL. Well-designed and long-term HRQoL studies are necessary to ascertain sustained benefits of OIT and OFCs.
BACKGROUND: Food allergy (FA) is a growing global problem that can affect patients' health-related quality of life (HRQoL) owing to increased anxiety as well as social and economic restrictions. Interventions such as oral food challenges (OFCs) and oral immunotherapy (OIT) have been shown to improve HRQoL. However, meta-analyses and systematic synthesis of these data are lacking. OBJECTIVE: To review and quantitatively synthesize potential benefits of interventions (OIT and OFC) systematically to address FA to a variety of foods. METHODS: We conducted a systematic search through PubMed and Cochrane Medical Library databases and performed a meta-analysis focusing on studies assessing changes in HRQoL after OIT and/or OFCs in FA participants and caregivers from 2010 to July 2020. Random effects model and I2 statistics were used to assess overall intervention effects and heterogeneity across studies. RESULTS: We included 13 publications in this meta-analysis (OIT = 7; OFCs = 6). Mean change in HRQoL scores after OIT and OFCs was -1.25 (P < .001) and -0.78 (P = .052), with a significant I2 of 87% (P < .001) and 90% (P < .001), respectively. Five OIT studies found significant improvements in HRQoL in the OIT group compared with the placebo group, with an overall standardized mean difference of -0.56 (P = .007; I2 = 42%, P = .099). CONCLUSIONS: This meta-analysis showed that in FA patients, both OIT and OFCs are associated with an improvement in HRQoL. Well-designed and long-term HRQoL studies are necessary to ascertain sustained benefits of OIT and OFCs.
Authors: Susan A Rudders; Aleena Banerji; Milo F Vassallo; Sunday Clark; Carlos A Camargo Journal: J Allergy Clin Immunol Date: 2010-08 Impact factor: 10.793
Authors: A DunnGalvin; C Cullinane; D A Daly; B M J Flokstra-de Blok; A E J Dubois; J O'B Hourihane Journal: Clin Exp Allergy Date: 2010-03 Impact factor: 5.018
Authors: Derek K Chu; Robert A Wood; Shannon French; Alessandro Fiocchi; Manel Jordana; Susan Waserman; Jan L Brożek; Holger J Schünemann Journal: Lancet Date: 2019-04-25 Impact factor: 79.321
Authors: Jonathan O'B Hourihane; Katrina J Allen; Wayne G Shreffler; Gillian Dunngalvin; Julie A Nordlee; Giovanni A Zurzolo; Audrey Dunngalvin; Lyle C Gurrin; Joseph L Baumert; Steve L Taylor Journal: J Allergy Clin Immunol Date: 2017-02-24 Impact factor: 10.793
Authors: Christopher M Warren; Ruchi S Gupta; Min-Woong Sohn; Elissa H Oh; Namit Lal; Craig F Garfield; Deanna Caruso; Xiaobin Wang; Jacqueline A Pongracic Journal: Ann Allergy Asthma Immunol Date: 2014-12-06 Impact factor: 6.347
Authors: J P M van der Valk; R Gerth van Wijk; B M J Flokstra-de Blok; J L van der Velde; H de Groot; H J Wichers; A E J Dubois; N W de Jong Journal: Pediatr Allergy Immunol Date: 2016-09-16 Impact factor: 6.377
Authors: T Umasunthar; J Leonardi-Bee; M Hodes; P J Turner; C Gore; P Habibi; J O Warner; R J Boyle Journal: Clin Exp Allergy Date: 2013-12 Impact factor: 5.018
Authors: Liselot De Vlieger; Lisa Nuyttens; Charlotte Matton; Marianne Diels; Sophie Verelst; Jasmine Leus; Katrien Coppens; Kate Sauer; Ellen Dilissen; Lieve Coorevits; Christophe Matthys; Rik Schrijvers; Marc Raes; Dominique M A Bullens Journal: Front Allergy Date: 2022-05-11
Authors: Kacper Packi; Joanna Matysiak; Sylwia Klimczak; Eliza Matuszewska; Anna Bręborowicz; Dagmara Pietkiewicz; Jan Matysiak Journal: Int J Environ Res Public Health Date: 2022-06-27 Impact factor: 4.614
Authors: Astrid Versluis; Thuy-My Le; Francine C van Erp; Mark A Blankestijn; Geert F Houben; André C Knulst; Harmieke van Os-Medendorp Journal: Clin Transl Allergy Date: 2022-02 Impact factor: 5.871
Authors: Sarah Alonzi; Thomas J Caruso; Sayantani B Sindher; Shu Cao; Sara Varadharajulu; William J Collins; R Sharon Chinthrajah Journal: Front Allergy Date: 2022-01-13