Richard Day1,2, Marlene Fransen3, Milena Simic4, Alison R Harmer3, Maria Agaliotis3,5, Lillias Nairn3, Lisa Bridgett3, Lyn March6, Milana Votrubec7, John Edmonds8, Mark Woodward9,10,11. 1. Department of Clinical Pharmacology, St Vincent's Hospital, Sydney, Australia. 2. St Vincent's Hospital Clinical School, University of New South Wales, Sydney, Australia. 3. Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia. 4. Faculty of Medicine and Health, Discipline of Physiotherapy, The University of Sydney, Sydney, Australia. milena.simic@sydney.edu.au. 5. Australia Institute of Health Service Management, University of Tasmania, Sydney, Australia. 6. Institute of Bone and Joint Research, The University of Sydney, Royal North Shore Hospital, Sydney, Australia. 7. Graduate School of Medicine, Notre Dame University, Sydney, Australia. 8. St George Hospital Clinical School, University of New South Wales, Sydney, Australia. 9. The George Institute for Global Health, University of New South Wales, Sydney, Australia. 10. The George Institute for Global Health, University of Oxford, Oxford, UK. 11. Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.
Abstract
BACKGROUND: The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis. METHODS: A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available). RESULTS: Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7). CONCLUSIONS: Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression. TRIAL REGISTRATION: ClinicalTrials.gov , NCT00513422 . This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.
BACKGROUND: The aim of this study was to identify modifiable clinical factors associated with radiographic osteoarthritis progression over 1 to 2 years in people with painful medial knee osteoarthritis. METHODS: A longitudinal study was conducted within a randomised controlled trial, the "Long-term Evaluation of Glucosamine Sulfate" (LEGS study). Recruitment occurred in 2007-2009, with 1- and 2-year follow-up assessments by blinded assessors. Community-dwelling people with chronic knee pain (≥4/10) and medial tibiofemoral narrowing (but retaining >2mm medial joint space width) on radiographs were recruited. From 605 participants, follow-up data were available for 498 (82%, mean [sd] age 60 [8] years). Risk factors evaluated at baseline were pain, physical function, use of non-steroidal anti-inflammatory drugs (NSAIDs), statin use, not meeting physical activity guidelines, presence of Heberden's nodes, history of knee surgery/trauma, and manual occupation. Multivariable logistic regression analysis was conducted adjusting for age, sex, obesity, high blood pressure, allocation to glucosamine and chondroitin treatment, and baseline structural disease severity (Kellgren and Lawrence grade, joint space width, and varus alignment). Radiographic osteoarthritis progression was defined as joint space narrowing ≥0.5mm over 1 to 2 years (latest follow-up used where available). RESULTS: Radiographic osteoarthritis progression occurred in 58 participants (12%). Clinical factors independently associated with radiographic progression were the use of NSAIDs, adjusted odds ratios (OR) and 95% confidence intervals (CI) 2.05 (95% CI 1.1 to 3.8), and not meeting physical activity guidelines, OR 2.07 (95% CI 0.9 to 4.7). CONCLUSIONS: Among people with mild radiographic knee osteoarthritis, people who use NSAIDs and/or do not meet physical activity guidelines have a greater risk of radiographic osteoarthritis progression. TRIAL REGISTRATION: ClinicalTrials.gov , NCT00513422 . This original study trial was registered a priori, on August 8, 2007. The current study hypothesis arose before inspection of the data.
Authors: Marlene Fransen; Maria Agaliotis; Lillias Nairn; Milana Votrubec; Lisa Bridgett; Steve Su; Stephen Jan; Lyn March; John Edmonds; Robyn Norton; Mark Woodward; Richard Day Journal: Ann Rheum Dis Date: 2014-01-06 Impact factor: 19.103
Authors: K M Leyland; D J Hart; M K Javaid; A Judge; A Kiran; A Soni; L M Goulston; C Cooper; T D Spector; N K Arden Journal: Arthritis Rheum Date: 2012-07
Authors: Sandip Biswal; Trevor Hastie; Thomas P Andriacchi; Gabrielle A Bergman; Michael F Dillingham; Philipp Lang Journal: Arthritis Rheum Date: 2002-11
Authors: Saeid Safiri; Ali-Asghar Kolahi; Emma Smith; Catherine Hill; Deepti Bettampadi; Mohammad Ali Mansournia; Damian Hoy; Ahad Ashrafi-Asgarabad; Mahdi Sepidarkish; Amir Almasi-Hashiani; Gary Collins; Jay Kaufman; Mostafa Qorbani; Maziar Moradi-Lakeh; Anthony D Woolf; Francis Guillemin; Lyn March; Marita Cross Journal: Ann Rheum Dis Date: 2020-05-12 Impact factor: 19.103