Minlan Yuan1,2, Hongru Zhu1,2, Yuchen Li1,2, Fenfen Ge1,2, Su Lui3,4, Qiyong Gong3, Changjian Qiu1,2, Huan Song5,6, Wei Zhang7,8,9,10. 1. Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, 610041, Chengdu, China. 2. Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China. 3. Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, Sichuan, China. 4. Radiology Department of the Second Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. 5. West China Biomedical Big Data Center, West China Hospital, Sichuan University, 610041, Chengdu, China. songhuan@wchscu.cn. 6. Medical Big Data Center, Sichuan University, Chengdu, 610041, China. songhuan@wchscu.cn. 7. Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, 610041, Chengdu, China. weizhang27@163.com. 8. Huaxi Brain Research Center, West China Hospital of Sichuan University, Chengdu, China. weizhang27@163.com. 9. West China Biomedical Big Data Center, West China Hospital, Sichuan University, 610041, Chengdu, China. weizhang27@163.com. 10. Medical Big Data Center, Sichuan University, Chengdu, 610041, China. weizhang27@163.com.
Abstract
RATIONALE AND OBJECTIVES: The hippocampus, especially the CA1, CA3, and dentate gyrus (DG) subfields, is reported to be associated with post-traumatic stress disorder (PTSD) after trauma. However, neuroimaging studies of the associations between PTSD and hippocampal subfield volumes have failed to yield consistent findings. The aim of this study is to examine whether the dopamine D2 receptor (DRD2) Taq1A polymorphism, which is associated with both hippocampal function and PTSD, moderated the association between PTSD severity and hippocampal CA1, CA3 and DG volumes. METHODS: T1-weighted images were acquired from 142 trauma survivors from the 2008 Wenchuan earthquake using a 3.0-T magnetic resonance imaging system. Hippocampal subfield segmentations were performed with FreeSurfer v6.0. We used the simple moderation model from the PROCESS v3.4 tool for SPSS 23.0 to examine the association between the rs1800497 polymorphism, PTSD severity, and hippocampal CA3 and DG volumes. RESULTS: A significant genotype × PTSD symptom severity interaction was found for the left CA3 volume (ΔF = 5.01, p = 0.008, ΔR2 = 0.05). Post hoc, exploratory analyses deconstructing the interaction revealed that severe PTSD symptomatology were associated with reduced left CA3 volume among TC heterozygotes (t = - 2.86, p = 0.005). CONCLUSIONS: This study suggests that DRD2 Taq1A polymorphism moderates the association between PTSD symptomatology and left CA3 volume, which promotes an etiological understanding of the hippocampal atrophy at the subfield level. This highlights the complex effect of environmental stress, and provides possible mechanism for the relationship between the dopaminergic system and hippocampal function in PTSD.
RATIONALE AND OBJECTIVES: The hippocampus, especially the CA1, CA3, and dentate gyrus (DG) subfields, is reported to be associated with post-traumatic stress disorder (PTSD) after trauma. However, neuroimaging studies of the associations between PTSD and hippocampal subfield volumes have failed to yield consistent findings. The aim of this study is to examine whether the dopamine D2 receptor (DRD2) Taq1A polymorphism, which is associated with both hippocampal function and PTSD, moderated the association between PTSD severity and hippocampal CA1, CA3 and DG volumes. METHODS: T1-weighted images were acquired from 142 trauma survivors from the 2008 Wenchuan earthquake using a 3.0-T magnetic resonance imaging system. Hippocampal subfield segmentations were performed with FreeSurfer v6.0. We used the simple moderation model from the PROCESS v3.4 tool for SPSS 23.0 to examine the association between the rs1800497 polymorphism, PTSD severity, and hippocampal CA3 and DG volumes. RESULTS: A significant genotype × PTSD symptom severity interaction was found for the left CA3 volume (ΔF = 5.01, p = 0.008, ΔR2 = 0.05). Post hoc, exploratory analyses deconstructing the interaction revealed that severe PTSD symptomatology were associated with reduced left CA3 volume among TC heterozygotes (t = - 2.86, p = 0.005). CONCLUSIONS: This study suggests that DRD2 Taq1A polymorphism moderates the association between PTSD symptomatology and left CA3 volume, which promotes an etiological understanding of the hippocampal atrophy at the subfield level. This highlights the complex effect of environmental stress, and provides possible mechanism for the relationship between the dopaminergic system and hippocampal function in PTSD.
Authors: Dean G Kilpatrick; Kenneth J Ruggiero; Ron Acierno; Benjamin E Saunders; Heidi S Resnick; Connie L Best Journal: J Consult Clin Psychol Date: 2003-08
Authors: T Pohjalainen; J O Rinne; K Någren; P Lehikoinen; K Anttila; E K Syvälahti; J Hietala Journal: Mol Psychiatry Date: 1998-05 Impact factor: 15.992
Authors: L E Duncan; A Ratanatharathorn; A E Aiello; L M Almli; A B Amstadter; A E Ashley-Koch; D G Baker; J C Beckham; L J Bierut; J Bisson; B Bradley; C-Y Chen; S Dalvie; L A Farrer; S Galea; M E Garrett; J E Gelernter; G Guffanti; M A Hauser; E O Johnson; R C Kessler; N A Kimbrel; A King; N Koen; H R Kranzler; M W Logue; A X Maihofer; A R Martin; M W Miller; R A Morey; N R Nugent; J P Rice; S Ripke; A L Roberts; N L Saccone; J W Smoller; D J Stein; M B Stein; J A Sumner; M Uddin; R J Ursano; D E Wildman; R Yehuda; H Zhao; M J Daly; I Liberzon; K J Ressler; C M Nievergelt; K C Koenen Journal: Mol Psychiatry Date: 2017-04-25 Impact factor: 15.992