Literature DB >> 34085053

Emergency department provider in triage: assessing site-specific rationale, operational feasibility, and financial impact.

Brian J Franklin1, Kathleen Y Li2,3,4, David M Somand3,5, Keith E Kocher2,3, Steven L Kronick3, Vikas I Parekh6, Eric Goralnick7,8, A Tyler Nix9, Nathan L Haas3,5.   

Abstract

Emergency department (ED) crowding is recognized as a critical threat to patient safety, while sub-optimal ED patient flow also contributes to reduced patient satisfaction and efficiency of care. Provider in triage (PIT) programs-which typically involve, at a minimum, a physician or advanced practice provider conducting an initial screening exam and potentially initiating treatment and diagnostic testing at the time of triage-are frequently endorsed as a mechanism to reduce ED length of stay (LOS) and therefore mitigate crowding, improve patient satisfaction, and improve ED operational and financial performance. However, the peer-reviewed evidence regarding the impact of PIT programs on measures including ED LOS, wait times, and costs (as variously defined) is mixed. Mechanistically, PIT programs exert their effects by initiating diagnostic work-ups earlier and, sometimes, by equipping triage providers to directly disposition patients. However, depending on local contextual factors-including the co-existence of other front-end interventions and delays in ED throughput not addressed by PIT-we demonstrate how these features may or may not ultimately translate into reduced ED LOS in different settings. Consequently, site-specific analysis of the root causes of excessive ED LOS, along with mechanistic assessment of potential countermeasures, is essential for appropriate deployment and successful design of PIT programs at individual EDs. Additional motivations for implementing PIT programs may include their potential to enhance patient safety, patient satisfaction, and team dynamics. In this conceptual article, we address a gap in the literature by demonstrating the mechanisms underlying PIT program results and providing a framework for ED decision-makers to assess the local rationale for, operational feasibility of, and financial impact of PIT programs.
© 2021 The Authors. JACEP Open published by Wiley Periodicals LLC on behalf of American College of Emergency Physicians.

Entities:  

Keywords:  emergency department boarding; emergency department crowding; emergency department physician in triage; emergency department provider in triage; hospital capacity; patient flow; patient safety; patient satisfaction

Year:  2021        PMID: 34085053      PMCID: PMC8144283          DOI: 10.1002/emp2.12450

Source DB:  PubMed          Journal:  J Am Coll Emerg Physicians Open        ISSN: 2688-1152


INTRODUCTION

Organizations, including The Joint Commission and the American College of Emergency Physicians, have long recognized the need to mitigate emergency department (ED) crowding as an urgent patient safety priority. , ED crowding, which occurs when the number of patients receiving care exceeds treatment space capacity, has been associated with delayed antibiotic administration, a higher likelihood of adverse events, prolonged wait times, and increasing rates of patients who leave without being seen (LWBS), among other deleterious effects. , , , , Prolonged patient length of stay (LOS) in the ED both contributes to, and is exacerbated by, ED crowding. , , Many causes of prolonged ED LOS—such as boarding of patients admitted from the ED due to inpatient bed unavailability—require hospital‐wide countermeasures to address. , , However, there also is interest in mitigating ED crowding by accelerating patient flow within the ED itself. Provider in triage (PIT)—which typically involves a physician or advanced practice provider conducting an initial screening examination and potentially initiating diagnostic testing and treatment at triage—has been proposed as one ED‐controllable mechanism to reduce ED LOS. PIT programs often are endorsed as a mechanism to mitigate ED crowding, , , , , yet the peer‐reviewed evidence regarding their impact on measures, including ED LOS, wait times, and costs (as variously defined), is mixed. Existing systematic reviews have demonstrated significant heterogeneity in study design, PIT program design, and results, which they attribute in part to the critical influence of local contextual factors, without elucidating these factors in depth. , , Although these findings are important for characterizing the literature on PIT programs, they are not generalizable to—and therefore are of limited use for—local decision‐makers contemplating, designing, or assessing performance of PIT programs in individual EDs. Consequently, we seek in this conceptual article to fill a gap in the literature by providing a structured resource to guide ED decision‐makers in their initial evaluation of PIT programs in the context of their local operations. Specifically, our objectives are to (1) illustrate the primary mechanisms underlying PIT programs, and (2) provide a framework for ED decision‐makers to assess the local rationale for feasibility of and financial impact of PIT programs, accounting for their potential influence on patient flow, patient safety, patient satisfaction, and team dynamics.

LITERATURE REVIEW

Working with a medical librarian (A.T.N.), we queried PubMed for peer‐reviewed literature related to PIT programs (Appendix 1). We hand‐searched selected reference lists to identify additional citations. The objective of our evidence synthesis was to identify major ideas and models related to PIT, rather than provide an exhaustive review of the literature. We included articles in our synthesis if they (1) reported outcomes of 1 or more PIT implementations, or (2) offered perspectives related to PIT. A reviewer (B.J.F.) used our data extraction form to evaluate articles against the aforementioned eligibility criteria and categorize their content. Themes were determined by co‐authors’ review and discussion. Our search yielded 504 unique articles, of which 64 met our criteria for review. Eight articles were systematic reviews, including 3 meta‐analyses. The remaining 56 articles primarily described individual PIT implementations or offered perspectives regarding PIT. The literature demonstrates significant heterogeneity in both the design (Figure 1) and outcomes of PIT programs. Key differences among existing PIT programs include provider and clinical support staffing models, scope of work, patients and acuity levels seen, and type of space repurposed, remodeled, or added. Table 1 summarizes evidence from the three systematic reviews with meta‐analysis.
FIGURE 1

Provider in triage program design variables. NP, nurse practitioner; PA, physician assistant; POC, point of care; RN, registered nurse

TABLE 1

Summary of results of systematic reviews with meta‐analysis of provider in triage programs

ReferenceNo. of studies reviewed, by country of originWait time (arrival to provider evaluation)LWBS/LWTCED LOSAdverse eventsPatient satisfactionReturn on investment
Benabbas et al18 United States (12)NR

In 10 studies, RR of LWBS ranged from 0.15 to 0.95 (results too heterogenous to pool data)

In 2 studies, RR of LWTC was 0.60 (95% CI, 0.57–0.64)

In 9 studies, mean difference of ED LOS pre‐ and post‐PIT ranged from −82 to +20 min (results too heterogenous to pool data). Stratification of studies by disposition (admit vs discharge) did not decrease heterogeneity.NRNRNR
Ming et al19 Canada (2), United States (1), United Kingdom (1)1 study reported a reduction in wait time of 26 min (P < 0.001) 21 NR2 of 4 studies reported a statistically significant reduction in LOS ranging from 24 to 36 min 21 , 22 NRNRNR
Abdulwahid et al20 United States (12), Australia (5), Canada (2), United Kingdom (2), Hong Kong (1), Jamaica (1), Singapore (1), Sweden (1)

2 of 2 RCTs demonstrated a significant reduction in WT (WMD −26.17 minutes, 95% CI, −31.68 to −20.65)

9 of 11 non‐RCTs demonstrated a significant reduction in WT with median difference of −15 min (IQR = −7.5 to −18)

2 of 2 RCTs demonstrated a significant reduction in LWBS (RR = 0.79, 95% CI, 0.66–0.94)

8 of 12 non‐RCTs demonstrated statistically significant reduction in LWBS

1 of 1 RCTs did not demonstrate a significant reduction in LWTC

3 of 3 non‐RCTs demonstrated a significant reduction in LWTC rates

2 of 4 RCTs reported a significant reduction in LOS 21 , 22

1 observational study demonstrated a statistically significant reduction in mortality (P < 0.001) 23

1 study demonstrated a significant improvement in unplanned reattendance 23

1 of 3 RCTs demonstrated a significant improvement in Press Ganey overall rating of ED care from 4.22 to 4.38 (P = 0.013) 24 1 study reported a positive return on investment (as quantified by net present value of $2.82 M and breakeven time of 13 months) 25

Abbreviations: CI, confidence interval; ED, emergency department; LOS, length of stay; LWBS, left without being seen; LWTC, left without treatment complete (seen by a provider but left the ED before completion of treatment); NR, not reported; PIT, provider in triage; RCT, randomized controlled trial; RR, risk ratio; WMD, weighted mean difference; WT, wait time (arrival to provider evaluation).

Provider in triage program design variables. NP, nurse practitioner; PA, physician assistant; POC, point of care; RN, registered nurse Summary of results of systematic reviews with meta‐analysis of provider in triage programs In 10 studies, RR of LWBS ranged from 0.15 to 0.95 (results too heterogenous to pool data) In 2 studies, RR of LWTC was 0.60 (95% CI, 0.57–0.64) 2 of 2 RCTs demonstrated a significant reduction in WT (WMD −26.17 minutes, 95% CI, −31.68 to −20.65) 9 of 11 non‐RCTs demonstrated a significant reduction in WT with median difference of −15 min (IQR = −7.5 to −18) 2 of 2 RCTs demonstrated a significant reduction in LWBS (RR = 0.79, 95% CI, 0.66–0.94) 8 of 12 non‐RCTs demonstrated statistically significant reduction in LWBS 1 of 1 RCTs did not demonstrate a significant reduction in LWTC 3 of 3 non‐RCTs demonstrated a significant reduction in LWTC rates 1 observational study demonstrated a statistically significant reduction in mortality (P < 0.001) 1 study demonstrated a significant improvement in unplanned reattendance Abbreviations: CI, confidence interval; ED, emergency department; LOS, length of stay; LWBS, left without being seen; LWTC, left without treatment complete (seen by a provider but left the ED before completion of treatment); NR, not reported; PIT, provider in triage; RCT, randomized controlled trial; RR, risk ratio; WMD, weighted mean difference; WT, wait time (arrival to provider evaluation).

RATIONALE TO IMPLEMENT PIT

PIT is deployed to mitigate ED crowding by targeting ED throughput and output. Two major goals for implementing PIT are reducing LWBS and reducing ED LOS (Figure 2).
FIGURE 2

Mechanisms by which PIT programs may improve ED performance. ED, emergency department; LOS, length of stay; LWBS, left without being seen

Mechanisms by which PIT programs may improve ED performance. ED, emergency department; LOS, length of stay; LWBS, left without being seen Additional rationales for implementing PIT may include enhancing patient satisfaction, patient safety, and team dynamics, as further discussed below. Finally, the COVID‐19 pandemic may renew interest in interventions, including PIT, designed to increase ED capacity. Solutions targeting ED crowding are particularly relevant because facilitating physical distancing in waiting and treatment areas, which is difficult to achieve in EDs operating at extremely high occupancy, may influence patient perceptions of safety and willingness to seek in‐person care. , Next, we discuss the mechanisms by which PIT theoretically promotes reduced LWBS and ED LOS, factors counteracting PIT efficacy, alternatives or complements to PIT (Table 2), and a framework for assessing cost‐effectiveness.
TABLE 2

Examples of other countermeasures targeting LWBS and/or ED LOS

CountermeasureDirectly targets
LWBSED LOS
Immediate bedding
Fast track/split‐flow
Triage nursing orders
Rapid medical evaluation a
Improving test turnaround times

Point of care testing (at triage or at bedside)

ED‐based satellite laboratories

“Stat,” ED‐dedicated laboratory and radiology services

Bedside registration

Abbreviations: ED, emergency department; LOS, length of stay; LWBS, left without being seen; PIT, provider in triage.

Rapid medical evaluation has been variously defined to include triage nursing orders +/− PIT +/− split flow. , , .

Examples of other countermeasures targeting LWBS and/or ED LOS Point of care testing (at triage or at bedside) ED‐based satellite laboratories “Stat,” ED‐dedicated laboratory and radiology services Abbreviations: ED, emergency department; LOS, length of stay; LWBS, left without being seen; PIT, provider in triage. Rapid medical evaluation has been variously defined to include triage nursing orders +/− PIT +/− split flow. , , .

REDUCING LEFT WITHOUT BEING SEEN RATES

Motivations

The desire to reduce LWBS is motivated by concerns related to patient safety, patient satisfaction, and foregone revenue. Prolonged wait times drive ED patient elopement and the risk of certain unseen patients experiencing adverse outcomes after leaving. , Financially, increased LWBS results in foregone revenue and exposes health systems to medicolegal risk, though PIT introduces its own medicolegal considerations related to screening exam adequacy. ,

Mechanisms and evidence

Unless an ED has an immediate bedding policy and treatment spaces are routinely available, placing a provider at triage is likely to reduce the time from arrival to provider evaluation. In turn, as wait times drive elopement, reducing time from arrival to provider evaluation drives reduced LWBS (Figure 2). As shown in Table 1, a majority of studies reviewed by Abdulwahid et al and Ming et al demonstrate significant reductions in time from arrival to provider evaluation following PIT implementation. Additionally, a majority of these studies demonstrate significant reductions in LWBS.

REDUCING ED LENGTH OF STAY

Although PIT is likely to reduce time from arrival to provider (and therefore LWBS), the mechanisms and evidence base supporting PIT as a technique to reduce ED LOS are significantly more context‐dependent. PIT is thought to promote reduced ED LOS by (1) decreasing time from patient arrival to resulted tests by ordering tests earlier, and/or (2) decreasing time from patient arrival to disposition by permitting triage providers to directly treat and disposition certain patients (eg, discharge low‐acuity patients and/or admit medium‐acuity patients) (Figure 2). In Benabbas et al's systematic review, 11 of the 11 studies reviewed reported triage providers initiated diagnostic testing and treatment, 5 of 11 studies reported triage providers discharged patients, and 4 of 11 studies reported triage providers both admitted and discharged patients.

Arrival to resulted tests

Intuitively, PIT facilitates earlier test ordering, which—assuming sufficient resources exist to fulfill these orders—generally leads to earlier test results. However, whether accelerating test results ultimately reduces ED LOS—and whether PIT is the most optimal means of doing so—depends on local contextual factors. For example, after implementing PIT, Han et al reported a modest decrease in ED LOS for discharged patients, but no decrease in ED LOS for admitted patients. Concurrently, boarding times—the time elapsed between inpatient bed request and patient exit from the ED—for admitted patients increased by 9 minutes during the intervention period. This finding demonstrates how, for EDs in hospitals facing inpatient bed capacity constraints, accelerating a patient's workup and disposition may not ultimately reduce their ED LOS. Figure 3 illustrates a hypothetical scenario in which the next inpatient bed becomes available at 4:00 PM regardless of when admission orders are placed (ignoring the nuance that requesting a bed earlier may provide more time for the hospital to address capacity—for example, by summoning additional resources, accelerating discharges, or activating a surge plan). In this scenario, accelerating the patient's workup and admission merely results in boarding beginning earlier, with no effect on ED LOS.
FIGURE 3

Reducing time to disposition does not decrease ED LOS in the event of inpatient bed capacity constraint

Reducing time to disposition does not decrease ED LOS in the event of inpatient bed capacity constraint Stated more generally, accelerating time to resulted tests will not decrease ED LOS if testing is not on the critical path. In project management, the critical path is defined as the longest path from project start (patient arrival) to finish (patient exit from the ED); the sum of activities on the critical path is the minimum time necessary to complete the entire project. As Figure 4 illustrates, in this simplified hypothetical scenario, the critical path (depicted in red) is 135 minutes and involves waiting for specialty consultation. Even if time from arrival to resulted tests (currently 75 minutes) is shortened, because the consultant will not be available to evaluate test results any earlier (ie, because testing is not on the critical path), the patient's ED LOS will remain unchanged.
FIGURE 4

Reducing time to resulted tests does not decrease ED LOS if testing time is not on the critical path (depicted in red)

Reducing time to resulted tests does not decrease ED LOS if testing time is not on the critical path (depicted in red)

Alternative approaches to achieving earlier resulting of tests

Triage nursing orders

PIT facilitates earlier ordering of tests. An alternative approach to accelerating test ordering is equipping registered nurses (RNs) at triage with standard order sets for laboratory or imaging studies based on chief complaint, ideally informed by evidence‐based testing protocols. A variety of studies have documented reduced ED LOS, treatment time, or time to disposition after implementing triage nursing orders (TNOs). , , , , , When comparing PIT against TNOs, ED decision‐makers should consider whether a high proportion of patients could have an appropriate work‐up initiated by a triage RN, which may obviate the role of PIT in accelerating test ordering. Balance measures to consider when ordering tests at triage based on minimal history and exam—whether through TNOs or PIT—include the percentage of tests ordered at triage that prove to be clinically irrelevant, along with the percentage of patients who have a separate diagnostic work‐up initiated by the treating clinician because the initial work‐up was insufficient or inappropriate (thus paradoxically negating the benefit of earlier resulting of those tests, and ultimately leading to over‐testing). , An alternative hypothesis is that PIT could actually reduce unnecessary testing compared to TNOs to the extent triage providers place more targeted orders.

Improving test turnaround times

Another approach to decreasing ED LOS involves reducing test order‐to‐result turnaround times, which can account for a significant proportion of LOS. Strategies to reduce ED testing turnaround times including point‐of‐care testing (at triage or bedside), ED‐based satellite laboratories, and “stat,” ED‐dedicated laboratory and radiology services. , , , , Costs and benefits of these alternative strategies should be compared against those of PIT.

Discharge from triage

Multiple studies have described PIT programs in which triage clinicians directly disposition patients. However, as with reducing time to resulted tests, evidence regarding direct disposition of patients on ED LOS is mixed. For example, in contrast to Han et al, who reported PIT decreased ED LOS only for discharged patients, Imperato et al reported much more pronounced reductions in ED LOS for admitted patients, with minimal impact on LOS for discharged patients. Although in Imperato et al the triage physician was permitted to directly discharge patients, this study also involved concurrent use of a fast track area staffed by a physician assistant (ie, a split‐flow model ), which may have siphoned off many low‐acuity, easily discharged patients. Nestler et al , found PIT in combination with a fast track area was associated with reduced ED LOS, whereas these benefits were lost when PIT alone was trialed. An area for future research relates to potential benefits and costs of assigning non‐provider support for PIT programs. For example, could a dedicated triage treatment/discharge nurse, charged with frequently reassessing patient progress and test results, allow the triage provider to focus on decision‐making, reduce non‐value‐added time, and facilitate faster patient disposition? Neither Imperato et al nor Nestler et al comment on average wait time for the fast track area. Generally, however, if a fast track area exists, the effect of PIT on fast track patients conceptually depends on the average wait time to see the fast track provider. If there are typically lengthy wait times to see a fast track provider, then PIT may decrease ED LOS by either (1) initiating diagnostic workups earlier (as previously discussed), or (2) directly dispositioning patients (essentially serving as another fast track provider). If, alternatively, there is minimal wait time to see a fast track provider, then having a triage provider order diagnostic testing may have little effect on ED LOS for fast track patients. The expected site‐specific effects of PIT must be considered in the context of other front‐end interventions, including fast track.

TELE‐INTAKE

Some EDs have deployed telemedicine to place virtual providers at triage, who may perform tasks equivalent to those of their in‐person PIT counterparts (initial screening exam and order placement), though with potential differences in billability for these services. , , , Other than differences in team dynamics resulting from virtual (vs physical) collaboration and unfamiliar co‐workers (in the case of contracted providers), these tele‐intake programs may influence patient flow and safety by the same mechanisms as in‐person PIT programs. The COVID‐19 pandemic has renewed interest in tele‐intake given its potential to reduce contacts among patients and caregivers. ,

ASSESSING FINANCIAL IMPACT

PIT programs may involve annualized expenditures of hundreds of thousands of dollars, depending on incremental staffing requirements. To ensure organizational viability and value for patients, assessing quantitative and qualitative return on investment (ROI) of PIT programs is critical. Assessing quantitative ROI involves evaluating annual cash flows from PIT, including those noted in Table 3. Contribution margin is calculated as collected revenues from patient care less direct costs of providing that care. In a fee‐for‐service environment, collected revenues are a function of the number of incremental patients, charges per patient (based on payer mix and intensity of care), collection rate, and participation in value‐based payment programs. Specific methods for approaching these calculations are beyond the scope of this paper. Generally, however, return on investment may be quantified using methods including payback period, net present value, and internal rate of return. Soremekun et al illustrate these assessments (although depreciation expense should be excluded from net present value calculations). Kezirian et al and Cheng et al describe additional approaches to quantify ROI.
TABLE 3

PIT program cash flows

Positive cash flowsNegative cash flows

Contribution margin a from:

Recaptured LWBS patients

Recaptured ambulance diversion patients

Other incremental patients

Reduced staffing costs resulting from reduced ED crowing

One‐time capital expenditures (eg, to repurpose, remodel, or add space)

Recurring expenses

Incremental salary expense of PIT providers and staff b

Other PIT‐related operating expenses

Abbreviations: LWBS, left without being seen; PIT, provider in triage.

Contribution margin is calculated as collected revenues from patient care less direct costs of providing that care. Collected revenues are a function of factors including the number of incremental patients, charges per patient (which depends on payer mix and intensity of care), collection rate, and participation in value‐based payment programs.

If no net additional hours are paid (ie, if existing staff are redeployed to the PIT program), then this figure should be calculated as the opportunity cost associated with the full‐time equivalent personnel allocated to the PIT program.

PIT program cash flows Contribution margin from: Recaptured LWBS patients Recaptured ambulance diversion patients Other incremental patients Reduced staffing costs resulting from reduced ED crowing One‐time capital expenditures (eg, to repurpose, remodel, or add space) Recurring expenses Incremental salary expense of PIT providers and staff Other PIT‐related operating expenses Abbreviations: LWBS, left without being seen; PIT, provider in triage. Contribution margin is calculated as collected revenues from patient care less direct costs of providing that care. Collected revenues are a function of factors including the number of incremental patients, charges per patient (which depends on payer mix and intensity of care), collection rate, and participation in value‐based payment programs. If no net additional hours are paid (ie, if existing staff are redeployed to the PIT program), then this figure should be calculated as the opportunity cost associated with the full‐time equivalent personnel allocated to the PIT program. For EDs considering PIT in a fee‐for‐service environment, the most complex—and essential—component of assessing quantitative ROI is estimating the number of patients likely to be recaptured from LWBS and ambulance diversions, along with any incremental patients seen due to increased ED capacity. These estimates require considerable local analysis because they rely on understanding the site‐specific mechanistic drivers of how PIT would—or would fail to—lead to the desired outcomes illustrated in Figure 2. Overall, regardless of payment model, when contemplating PIT programs, it is critical for ED decision‐makers to: articulate the problem(s) they are attempting to solve (eg, excessive LWBS or ED LOS), undertake rigorous analysis (eg, using A3 problem solving ) to identify the local root causes of these problems, and assess mechanistically and quantitatively the extent to which PIT would address these root causes.

LIMITATIONS OF LITERATURE AND OTHER IMPORTANT CONSIDERATIONS

Further important considerations regarding PIT feasibility, which may not be easily quantified, include potential influence of PIT programs on the following: Patient safety and outcomes: PIT may facilitate earlier recognition and treatment of time‐sensitive conditions (eg, myocardial infarction, stroke, sepsis, etc.) and pain, as well as guard against patient deterioration in the waiting room. Patient satisfaction: by reducing time from arrival to evaluation (and potentially reducing ED LOS), PIT may enhance the patient experience. , Clinician satisfaction and teamwork: triage nurses may feel more supported by the presence of triage providers when managing busy waiting rooms. Graduate medical education: while serving as a triage provider might confer new learning opportunities to residents, in cases where residents do not work in triage, PIT programs might reduce opportunities for residents to formulate their own assessments and plans. , Medicolegal considerations: PIT may introduce medicolegal considerations related to screening exam adequacy. Further literature elucidating these considerations would help inform PIT program design and potentially enhance providers’ buy‐in. Although challenging to measure and apparently addressed by only a narrow body of literature, these factors must be considered in combination with the quantitative ROI to determine whether PIT is worthwhile at any single site.

CONCLUSION

PIT programs are frequently endorsed as a mechanism to reduce ED LOS and therefore mitigate ED crowding, yet evidence regarding their effectiveness is mixed. Existing systematic attribute the significant heterogeneity in PIT program results to local contextual factors, without elucidating these factors in depth. Mechanistically, PIT programs exert their effects by reducing time from arrival to resulted tests and by equipping triage providers to directly disposition patients. However, depending on local contextual factors—including the coexistence of other front‐end interventions and delays in ED throughput not addressed by PIT—we illustrate how these features may or may not ultimately translate into reduced ED LOS. Consequently, site‐specific analysis of the root causes of excessive ED LOS and mechanistic assessment of potential countermeasures is essential for appropriate deployment and successful design of PIT programs. Additional motivations for implementing PIT programs may include their potential to facilitate enhanced patient safety, patient satisfaction, and team dynamics. In this conceptual article, we address a gap in the literature by demonstrating the mechanisms underlying PIT program results and providing a framework for ED decision‐makers to assess the site‐specific rationale for, operational feasibility of, and cost‐effectiveness of PIT programs.

AUTHOR CONTRIBUTIONS

BJF, DMS, KYL, and NLH conceptualized the project. ATN and BJF developed the literature search strategy. BJF screened articles for inclusion. BJF assumes responsibility for the article as a whole. All authors provided analysis and interpretation of the data, developed thematic concepts, and provided critical feedback related to the research and manuscript.

CONFLICTS OF INTEREST

The authors declare no conflicts of interest.
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