PURPOSE OF REVIEW: Present the state-of-the-art overview of laryngeal pacing for treatment of bilateral vocal fold paralysis. A minimally invasive unilateral pacing system and a fully implantable bilateral pacing system are currently in clinical trials. The relative advantages and disadvantages of each are discussed. RECENT FINDINGS: Research in functional electrical stimulation for the reanimation of the posterior cricoarytenoid muscle has successfully translated from animal models to human clinical trials for unilateral pacing and bilateral pacing. Current findings suggest unilateral pacing in humans significantly improves ventilation but only marginally better than cordotomy. Bilateral pacing in canines increases glottal opening greater than 2-fold over unilateral pacing and restores exercise tolerance to normal. SUMMARY: Unilateral pacing can be considered a breathing assist device and may not be appropriate for active individuals. Bilateral pacing may be preferable for patients who wish to engage in strenuous exercise. Minimally invasive systems may be ideal for patients who prefer less invasive implantation and are not concerned with cosmesis. Fully implantable pacing systems offer greater electrode redundancy and stability, resulting in a system that is robust against electrode migration or damage.
PURPOSE OF REVIEW: Present the state-of-the-art overview of laryngeal pacing for treatment of bilateral vocal fold paralysis. A minimally invasive unilateral pacing system and a fully implantable bilateral pacing system are currently in clinical trials. The relative advantages and disadvantages of each are discussed. RECENT FINDINGS: Research in functional electrical stimulation for the reanimation of the posterior cricoarytenoid muscle has successfully translated from animal models to human clinical trials for unilateral pacing and bilateral pacing. Current findings suggest unilateral pacing in humans significantly improves ventilation but only marginally better than cordotomy. Bilateral pacing in canines increases glottal opening greater than 2-fold over unilateral pacing and restores exercise tolerance to normal. SUMMARY: Unilateral pacing can be considered a breathing assist device and may not be appropriate for active individuals. Bilateral pacing may be preferable for patients who wish to engage in strenuous exercise. Minimally invasive systems may be ideal for patients who prefer less invasive implantation and are not concerned with cosmesis. Fully implantable pacing systems offer greater electrode redundancy and stability, resulting in a system that is robust against electrode migration or damage.
Authors: David L Zealear; Cheryl R Billante; Mark S Courey; James L Netterville; Randal C Paniello; Ira Sanders; Garrett D Herzon; George S Goding; Wolf Mann; Hasse Ejnell; Alfons M M C Habets; Roy Testerman; Paul Van de Heyning Journal: Laryngoscope Date: 2003-07 Impact factor: 3.325
Authors: Yike Li; Elizabeth C Pearce; Rajshri Mainthia; Sanjay M Athavale; Jennifer Dang; Daniel H Ashmead; C Gaelyn Garrett; Bernard Rousseau; Cheryl R Billante; David L Zealear Journal: ORL J Otorhinolaryngol Relat Spec Date: 2013-05-30 Impact factor: 1.538