Aamir H Twing1, Brody Slostad2, Christina Anderson3, Sreenivas Konda4, Elliott M Groves2, Mayank M Kansal2. 1. University of Illinois Chicago, Department of Medicine 840 South Wood Street, Chicago 60612, Illinois, USA. 2. University of Illinois Chicago, Division of Cardiology 840 South Wood Street Suite 920S, Chicago 60612, Illinois, USA. 3. Rush University, Division of Cardiology 1725 West Harrison Street Professional Building Suite 1159, Chicago 60612, Illinois, USA. 4. University of Illinois Chicago, School of Public Health, Division of Epidemiology and Biostatistics 1602 West Taylor Street, Chicago 60612, Illinois, USA.
Abstract
OBJECTIVE: In the United States, racial minorities are underrepresented among patients receiving transcatheter aortic valve replacement (TAVR) and data regarding their outcomes is limited. Global longitudinal strain (GLS) is a measure left ventricular function and has independently predicted outcomes after TAVR. The aim of this study is to assess changes in GLS after TAVR according to race and factors predicting these changes. METHODS: Electronic medical records of patients undergoing TAVR at the University of Illinois, Chicago and Jesse Brown Veteran's Administration Medical Center (Chicago, Illinois) from January 2017-February 2020 were reviewed retrospectively. The most recent transthoracic echocardiogram (TTE) prior to TAVR and the TTE 1-month post-procedure were used to determine GLS. Patients were included if both a pre- and post-procedure study were present and TTE images were of sufficient quality to process strain imaging. RESULTS: A total of 103 patients (average age 76 ± 12 years, 80% male, 42% white) were included. At 1-month post-TAVR, GLS improved for all races: white (-2.7 ± 3.5%, P<0.001), African-American (-2.8 ± 3.3%, P<0.001), and Hispanic (-2.0 ± 2.1%, P<0.001). There were no differences in the degree of improvement among races (P=0.62). Baseline GLS was negatively correlated with changes in GLS overall (r=-0.44, P<0.001). Baseline aortic valve area (cm2) was positively correlated with changes in GLS (r=0.2, P=0.036). CONCLUSIONS: This study demonstrated that GLS improved after TAVR independent of race with similar degrees of change across races. Baseline GLS and aortic valve area predicted strain improvement after TAVR, which suggests that those with more impaired LV function may benefit most from the procedure. AJCD
OBJECTIVE: In the United States, racial minorities are underrepresented among patients receiving transcatheter aortic valve replacement (TAVR) and data regarding their outcomes is limited. Global longitudinal strain (GLS) is a measure left ventricular function and has independently predicted outcomes after TAVR. The aim of this study is to assess changes in GLS after TAVR according to race and factors predicting these changes. METHODS: Electronic medical records of patients undergoing TAVR at the University of Illinois, Chicago and Jesse Brown Veteran's Administration Medical Center (Chicago, Illinois) from January 2017-February 2020 were reviewed retrospectively. The most recent transthoracic echocardiogram (TTE) prior to TAVR and the TTE 1-month post-procedure were used to determine GLS. Patients were included if both a pre- and post-procedure study were present and TTE images were of sufficient quality to process strain imaging. RESULTS: A total of 103 patients (average age 76 ± 12 years, 80% male, 42% white) were included. At 1-month post-TAVR, GLS improved for all races: white (-2.7 ± 3.5%, P<0.001), African-American (-2.8 ± 3.3%, P<0.001), and Hispanic (-2.0 ± 2.1%, P<0.001). There were no differences in the degree of improvement among races (P=0.62). Baseline GLS was negatively correlated with changes in GLS overall (r=-0.44, P<0.001). Baseline aortic valve area (cm2) was positively correlated with changes in GLS (r=0.2, P=0.036). CONCLUSIONS: This study demonstrated that GLS improved after TAVR independent of race with similar degrees of change across races. Baseline GLS and aortic valve area predicted strain improvement after TAVR, which suggests that those with more impaired LV function may benefit most from the procedure. AJCD
Authors: Miho Fukui; Jeffrey Xu; Islam Abdelkarim; Michael S Sharbaugh; Floyd W Thoma; Andrew D Althouse; Gianni Pedrizzetti; João L Cavalcante Journal: J Cardiovasc Comput Tomogr Date: 2018-10-29
Authors: L G Kearney; K Lu; M Ord; S K Patel; K Profitis; G Matalanis; L M Burrell; P M Srivastava Journal: Eur Heart J Cardiovasc Imaging Date: 2012-06-26 Impact factor: 6.875
Authors: Vasileios Kamperidis; Emer Joyce; Philippe Debonnaire; Spyridon Katsanos; Philippe J van Rosendael; Frank van der Kley; Georgios Sianos; Jeroen J Bax; Nina Ajmone Marsan; Victoria Delgado Journal: J Am Soc Echocardiogr Date: 2014-06-03 Impact factor: 5.251
Authors: Cesare Russo; Zhezhen Jin; Shunichi Homma; Tatjana Rundek; Mitchell S V Elkind; Ralph L Sacco; Marco R Di Tullio Journal: Am Heart J Date: 2015-02-21 Impact factor: 4.749
Authors: Michael Yeung; Jimmy Kerrigan; Sandeep Sodhi; Pei-Hsiu Huang; Eric Novak; Hersh Maniar; Alan Zajarias Journal: Am J Cardiol Date: 2013-06-20 Impact factor: 2.778
Authors: Aleksander Kempny; Gerhard-Paul Diller; Gerrit Kaleschke; Stefan Orwat; Angela Funke; Robert Radke; Renate Schmidt; Gregor Kerckhoff; Farshad Ghezelbash; Andreas Rukosujew; Holger Reinecke; Hans H Scheld; Helmut Baumgartner Journal: Int J Cardiol Date: 2012-07-04 Impact factor: 4.164
Authors: Stefan Hein; Eyal Arnon; Sawa Kostin; Markus Schönburg; Albrecht Elsässer; Victoria Polyakova; Erwin P Bauer; Wolf-Peter Klövekorn; Jutta Schaper Journal: Circulation Date: 2003-02-25 Impact factor: 29.690
Authors: E Mara Vollema; Tadafumi Sugimoto; Mylène Shen; Lionel Tastet; Arnold C T Ng; Rachid Abou; Nina Ajmone Marsan; Bart Mertens; Raluca Dulgheru; Patrizio Lancellotti; Marie-Annick Clavel; Philippe Pibarot; Philippe Genereux; Martin B Leon; Victoria Delgado; Jeroen J Bax Journal: JAMA Cardiol Date: 2018-09-01 Impact factor: 14.676