| Literature DB >> 34083450 |
Simone Brioschi1, Wei-Le Wang1, Vincent Peng1, Meng Wang2, Irina Shchukina1, Zev J Greenberg3, Jennifer K Bando4, Natalia Jaeger1, Rafael S Czepielewski1, Amanda Swain1, Denis A Mogilenko1, Wandy L Beatty5, Peter Bayguinov6, James A J Fitzpatrick6,7,8, Laura G Schuettpelz3, Catrina C Fronick9, Igor Smirnov1, Jonathan Kipnis1, Virginia S Shapiro10, Gregory F Wu11, Susan Gilfillan1, Marina Cella1, Maxim N Artyomov1, Steven H Kleinstein2,12, Marco Colonna13.
Abstract
The meninges contain adaptive immune cells that provide immunosurveillance of the central nervous system (CNS). These cells are thought to derive from the systemic circulation. Through single-cell analyses, confocal imaging, bone marrow chimeras, and parabiosis experiments, we show that meningeal B cells derive locally from the calvaria, which harbors a bone marrow niche for hematopoiesis. B cells reach the meninges from the calvaria through specialized vascular connections. This calvarial-meningeal path of B cell development may provide the CNS with a constant supply of B cells educated by CNS antigens. Conversely, we show that a subset of antigen-experienced B cells that populate the meninges in aging mice are blood-borne. These results identify a private source for meningeal B cells, which may help maintain immune privilege within the CNS.Entities:
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Year: 2021 PMID： 34083450 PMCID： PMC8448524 DOI： 10.1126/science.abf9277
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 63.714